目的總結microRNA（miRNA）與乳腺癌浸潤、轉移關系的研究進展。 方法檢索并篩選近年來國內(nèi)外發(fā)表的有關miRNA與乳腺癌浸潤、轉移關系的文獻并對其進行綜述。 結果許多miRNA在乳腺癌發(fā)生、發(fā)展與浸潤、轉移過程中都起著關鍵作用，按其作用可分為促癌miRNA（miR-21、miR-10b等）和抑癌miRNA（miR-31、let-7等）兩類。 結論miRNA調控乳腺癌浸潤及轉移的具體過程還需要更多、更詳細的實驗研究。
功能性單心室患者Fontan手術成功的關鍵主要取決于肺血管阻力。Fontan循環(huán)中高肺血管阻力將帶來各種并發(fā)癥，如運動耐量下降、低心排血量、心室功能衰竭和蛋白丟失性腸病，最終導致Fontan循環(huán)衰竭。因此，降低肺血管阻力的肺血管靶向藥物治療已成為學者近年的研究熱點。本綜述主要分析了靶向藥物波生坦和西地那非在肺動脈壓和肺血管阻力增高的Fontan患者圍術期中的有效性和安全性。
人類免疫缺陷病毒（human immunodeficiency virus，HIV）感染主要攻擊人類免疫系統(tǒng)，引起各種機會性感染和腫瘤的發(fā)生，其中合并腫瘤性疾病嚴重且危及患者生命。近年來，隨著高效抗反轉錄病毒的普及，HIV感染者疾病譜發(fā)生了很大變化，非獲得性免疫缺陷綜合征（acquired immune deficiency syndrome，AIDS）相關腫瘤的發(fā)病率明顯升高，食管癌合并HIV/AIDS患者的診出率也隨之升高。然而，目前對于食管癌合并HIV/AIDS的患者如何規(guī)范化診斷與治療，尚未達成共識。本文將對食管癌合并HIV/AIDS患者的流行病學特征及診治進展進行綜述。
高效抗逆轉錄病毒治療（HAART）能重建機體對巨細胞病毒（CMV）在內(nèi)的許多病原的免疫反應，不僅可以減少包括CMV視網(wǎng)膜炎在內(nèi)的CMV感染性疾病的危險，還可以延長獲得性免疫缺陷綜合征患者的生存期，提高生存率。但有必要加強HAART期間患者的免疫重建炎癥綜合征的監(jiān)護。
【摘要】 目的 探討重組人凝血因子Ⅷ制劑小劑量短程預防性輸注能否有效減少中重度血友病A患兒關節(jié)出血問題?！》椒ā?008年11月-2009年4月期間就診的13例年齡3~11歲的中重度血友病A患兒，均在為期2個月內(nèi)接受重組人凝血因子Ⅷ 2次/周、間隔3 d、每次7.5~10.0 U/kg的靜脈預防性輸注，記錄治療前2個月與治療2個月時關節(jié)出血次數(shù)，以及同一關節(jié)反復發(fā)生出血的情況?！〗Y果 治療前關節(jié)出血的發(fā)生次數(shù)為（3.77±2.13）次，治療后關節(jié)出血的發(fā)生次數(shù)為（0.46±0.87）次，治療前后比較，差異有統(tǒng)計學意義（Plt;0.01）；治療前靶關節(jié)出血的發(fā)生率為35.7％，治療后靶關節(jié)出血的發(fā)生率為0.0%，治療前后比較，差異有統(tǒng)計學意義（Plt;0.01）。患兒治療成本約510~680元/（kg?2個月）?！〗Y論 重組人凝血因子Ⅷ制劑小劑量短療程預防性輸注能有效減少中重度血友病A患兒關節(jié)出血次數(shù)，同時可有效減少靶關節(jié)出血的發(fā)生率，從而在一定程度上保護關節(jié)的功能。治療費用相對可接受。【Abstract】 Objective To evaluate the efficacy of low-dose short-course infusion of recombinant human factor Ⅷ concentration in treating joint bleeding in children with severe and moderate hemophilia A. Methods Thirteen children aged 3 to 11 years old with severe or moderate hemophilia A were included in the present study from November 2008 to April 2009. For children in the treatment group, they were treated with low-dose short-course infusion of recombinant human factor Ⅷ concentration with a dose of 7.5-10.0 U/kg twice weekly as secondary prophylaxis for two months. The incidence of joint bleeding 2 months before treatment (control group) and during the 2 months of treatment (treatment group) was observed. Moreover, the incidence of their target joint bleeding was measured in both groups. Results Children in the control group had (3.77±2.13) joint bleedings while children in the treatment group had (0.46±0.87) joint bleedings, which was obviously lower than those in the control group (Plt;0.01). Meanwhile, the incidence of target joint bleeding in the treatment group was 0%, which was obviously lower than that in the control group (35.7%) (Plt;0.01). In the treatment group, the costs of treatment were about RMB 510-680 yuan/kg every 2 months. Conclusions Treatment with low-dose short-course infusion of recombinant human factor Ⅷ concentration can effectively decrease joint bleeding in children with severe and moderate hemophilia A, and can effectively decrease the incidence of target joint bleeding. Therefore, this method may play an important role in protection of the joint function in those patients at an acceptable cost.
2007年1月-2009年12月，我們評價了彩色超聲心動圖在肥厚型梗阻性心肌病化學消融術中的應用價值，報告如下。