【摘要】 目的 探討阿托伐他汀強(qiáng)化降脂治療和左旋氨氯地平聯(lián)用對(duì)高血壓患者血壓的影響。 方法 選擇2009年1月-2010年11月住院及門診原發(fā)性高血壓合并高脂血癥患者196例，均給予左旋氨氯地平和阿托伐他汀治療8周后，復(fù)查血脂，從其中選擇血脂正常者120例，隨機(jī)分為對(duì)照組（單用左旋氨氯地平組）和治療組（繼續(xù)左旋氨氯地平聯(lián)用阿托伐他?。^續(xù)治療20周后的血壓情況。 結(jié)果 兩組治療20周后，治療組收縮壓和舒張壓均較對(duì)照組下降明顯，組間差異有統(tǒng)計(jì)學(xué)意義（Plt;0.01），治療組優(yōu)于對(duì)照組。 結(jié)論 高血壓合并高脂血癥患者，使用左旋氨氯地平降壓和阿托伐他汀降脂治療時(shí)，在血脂降至正常后，繼續(xù)同時(shí)左旋氨氯地平降壓和阿托伐他汀強(qiáng)化降脂治療，降壓效果優(yōu)于單用左旋氨氯地平?！続bstract】 Objective To investigate the effects of levamlodipine combined with atorvastatin on blood pressure in patients with primary hypertension. Methods Between January 2009 and November 2010, 196 patients with hypertension and hyperlipidemia in the outpatient and inpatient departments of our hospital were given levamlodipine and atorvastatin for 8 weeks, after which 120 patients with normal blood lipid were chosen and randomly divided into the control group (treated only by levamlodipine) and the treatment group (treated by levamlodipine combined with atorvastatin). After 20 weeks of the treatment, we observed their blood pressure. Results After twenty weeks of treatment, the diastolic and systolic pressure was significantly lower in the treatment group than that in the control group (Plt;0.01). Conclusion For patients with hypertension and hyperlipidemia who have undergone the treatment by levamlodipine and atorvastatin, after their blood lipid level decreases to normal, the continuous enhanced treatment by the two drugs has a better efficacy compared with the therapy of single levamlodipine in decreasing the blood lipid.