目的 評(píng)價(jià)FEV 及FEV1/FEV 在評(píng)定阻塞性通氣功能障礙方面的應(yīng)用價(jià)值,探討FEV1/FEV 能否替代FEV1/FVC用于評(píng)估氣道阻塞,并且對(duì)與FEV1/FVC lt;70% 對(duì)應(yīng)的FEV1/FEV 臨界值進(jìn)行探討。方法 應(yīng)用德國(guó)Jaeger公司生產(chǎn)的MasterScreen肺功能儀對(duì)128例門(mén)診及住院患者進(jìn)行肺功能測(cè)定,選用FEV1、FEV6、FVC、FEV1、FVC%pred,F(xiàn)EV1/FVC、FEV1/FEV6等作為分析指標(biāo)。以FEV1 /FVC lt;70%作為判斷有無(wú)氣流受限的“金標(biāo)準(zhǔn)”,以FEV %pred評(píng)估氣流受限程度。從ROC曲線分析決定最佳FEV1 /FEV6值;并對(duì)FEV1 /FVC與FEV1 /FEV6百分比之間關(guān)系進(jìn)行相關(guān)分析。結(jié)果 128例患者中,F(xiàn)EV1 /FVC≥70%者65例(51%),F(xiàn)EV1/FVC lt;70%者63例(49%)。在FEV1 /FVC lt;70% 的63例患者中,除5例FEV1/FEV6稍大于70%(70.09%~71%)外,其余均小于70% 。FVC實(shí)測(cè)值與FEV 實(shí)測(cè)值間無(wú)顯著差異。FEV1/FVC與FEV 1/FEV6呈高度正相關(guān)(r=0.997 9,P lt;0.000 1)。ROC曲線分析表明,以FEV1 /FEV6 lt;71.14%為診斷界值時(shí),對(duì)現(xiàn)有資料可以得到與FEV /FVC lt;70%完全一致的診斷結(jié)果。結(jié)論 FEV 1/FEV 6與FEV 1/FVC有相當(dāng)好的相關(guān)性,F(xiàn)EV1 /FEV 6有希望替代FEV1/FVC用于評(píng)定阻塞性通氣功能障礙。
引用本文: 蔣雷服,王虹,殷凱生,黃茂,孫培莉,馮源. 第6秒用力呼氣容積在評(píng)定阻塞性通氣功能障礙方面的應(yīng)用價(jià)值. 中國(guó)呼吸與危重監(jiān)護(hù)雜志, 2008, 08(6): 452-454. doi: 復(fù)制
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