• 解放軍第401醫(yī)院(青島266071);

目的  研究胃癌組織中nm23和CD44的表達(dá)，以及與淋巴結(jié)轉(zhuǎn)移和預(yù)后的關(guān)系。
方法  應(yīng)用SP免疫組化技術(shù)對105例胃癌組織nm23、CD44H和CD44V6的表達(dá)進(jìn)行觀察，并對其中59例患者隨訪。結(jié)果  nm23、CD44H及CD44V6蛋白表達(dá)陽性率分別為44.8%、54.3%和48.6%； nm23及CD44V6在胃癌組織的表達(dá)與其分化、浸潤深度、臨床分期和預(yù)后有關(guān)，而CD44H的表達(dá)與上述臨床病理指標(biāo)無關(guān)。3種抗體的陽性反應(yīng)與淋巴結(jié)轉(zhuǎn)移有關(guān)(nm23 Ｐ＜0.05； CD44V6 Ｐ＜0.01； CD44H Ｐ＜0.05)。
結(jié)論  CD44H的表達(dá)可用于監(jiān)測病情，而nm23和CD44V6有希望作為一個判斷預(yù)后的指標(biāo)。

引用本文： 金衛(wèi)中,楊東慧,趙景軒,薛佩蓮,鐘慧敏. nm23、CD44H和CD44V6蛋白在胃癌的表達(dá)及意義. 中國普外基礎(chǔ)與臨床雜志, 2000, 7(3): 141-143. doi: 復(fù)制

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3. Hennessy C, Henry JA, May FEB, et al. Expression of the antimetastic gene nm23 in human breast cancer: an association with good prognosis 〔Ｊ〕. J Natl Cancer Inst, 1991; 83(2)∶281.
4. Kodera Y, Isobe K, Yamanchi M, et al. Expression of nm23H1 RNA levels in human gastric cancer tissues: a negaive correlation with nodal metastasis 〔Ｊ〕. Cancer, 1994; 73(2)∶259.
5. Nakayama H, Yasui W, Yokozaki H, et al. Reduced expression of nm23 is associated with metastasis of human gastric carcinomas 〔Ｊ〕. Jpn J Cancer Res, 1993; 84(2)∶184.
6. Harn HJ, Ho LI, Chang JY, et al. Differential expression of the human metastasis adhesion molecule CD44V in normal and carcinomatous stomach mucosa of Chinese subjects 〔Ｊ〕. Cancer, 1995; 75(5)∶1065.
7. Mayer B, Jauch KW, Gunthert U, et al. Denovo expression of CD44 and survival in gastric cancer 〔Ｊ〕. Lancet, 1993; 342(8878)∶1019.
8. Streit M, Schmidt R, Hilgenfeld RU, et al. Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors 〔Ｊ〕. J Mol Med, 1996; 74(5)∶253.
9. Hong RL, Lee WJ, Shun CT, et al. Expression of CD44 and its clinical implication in diffusetype and intestinaltype gastric adenocarcinomas 〔Ｊ〕. Oncology, 1995; 52(4)∶334.
10. Tahara E, Semba S, Tahara H. Molecular biological observations in gastric cancer 〔Ｊ〕. Semin Oncol, 1996; 23(3)∶307.
11. Schildberg FW, Meyer G, Piltz S, et al. Surgical treatment of tumor metastasis: general considerations and results 〔Ｊ〕. Surg Today, 1995; 25(1)∶1.
  1. 1. 胡繼康，陳維鵬， 韓乃剛主編. 現(xiàn)代腫瘤外科學(xué) 〔M〕. 第1版. 北京： 中國科學(xué)技術(shù)出版社， 1994∶327～328.
  2. 2. Steeg PA, Bevilacqua G, Kopper L, et al. Evidence for a novel gene associated with a low tumor metastatic potential 〔Ｊ〕. J Natl Cancer Inst, 1988; 80(2)∶204.
  3. 3. Hennessy C, Henry JA, May FEB, et al. Expression of the antimetastic gene nm23 in human breast cancer: an association with good prognosis 〔Ｊ〕. J Natl Cancer Inst, 1991; 83(2)∶281.
  4. 4. Kodera Y, Isobe K, Yamanchi M, et al. Expression of nm23H1 RNA levels in human gastric cancer tissues: a negaive correlation with nodal metastasis 〔Ｊ〕. Cancer, 1994; 73(2)∶259.
  5. 5. Nakayama H, Yasui W, Yokozaki H, et al. Reduced expression of nm23 is associated with metastasis of human gastric carcinomas 〔Ｊ〕. Jpn J Cancer Res, 1993; 84(2)∶184.
  6. 6. Harn HJ, Ho LI, Chang JY, et al. Differential expression of the human metastasis adhesion molecule CD44V in normal and carcinomatous stomach mucosa of Chinese subjects 〔Ｊ〕. Cancer, 1995; 75(5)∶1065.
  7. 7. Mayer B, Jauch KW, Gunthert U, et al. Denovo expression of CD44 and survival in gastric cancer 〔Ｊ〕. Lancet, 1993; 342(8878)∶1019.
  8. 8. Streit M, Schmidt R, Hilgenfeld RU, et al. Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors 〔Ｊ〕. J Mol Med, 1996; 74(5)∶253.
  9. 9. Hong RL, Lee WJ, Shun CT, et al. Expression of CD44 and its clinical implication in diffusetype and intestinaltype gastric adenocarcinomas 〔Ｊ〕. Oncology, 1995; 52(4)∶334.
  10. 10. Tahara E, Semba S, Tahara H. Molecular biological observations in gastric cancer 〔Ｊ〕. Semin Oncol, 1996; 23(3)∶307.
  11. 11. Schildberg FW, Meyer G, Piltz S, et al. Surgical treatment of tumor metastasis: general considerations and results 〔Ｊ〕. Surg Today, 1995; 25(1)∶1.