• 蘭州大學(xué)第二醫(yī)院普外科（蘭州730000）;

【摘要】目的 探討梗阻性黃疸對肝臟分泌胰島素樣生長因子-1（IGF-1）的影響。
方法 收集20例梗阻性黃疸患者的臨床資料， 并對患者血清TNF-α、肝功能指標(biāo)（ALT、ALP、TB）、 內(nèi)毒素(ET)及 IGF-1進(jìn)行檢測。
結(jié)果 良性梗阻性黃疸患者與單純膽囊結(jié)石患者相比，IGF-1明顯降低（P＜0.01），而ET、TNFα、ALT、ALP及TB均明顯升高（P＜0.01）； 在膽道梗阻解除后，IGF-1明顯上升，ET、TNF-α、ALT、ALP及TB則明顯下降（P＜0.01）。 在良性梗阻性黃疸時，血清中 IGF-1濃度的變化與ET的濃度變化呈負(fù)相關(guān)（r=-0.761,P＜0.01）。
結(jié)論 梗阻性黃疸時，內(nèi)毒素血癥可影響肝臟分泌IGF-1，而IGF-1則可以作為判斷梗阻性黃疸時肝臟功能改變的指標(biāo)。

引用本文： 尹蘭寧,侯治軍,宋愛琳,寇治民. 良性梗阻性黃疸患者血清中IGF-1變化的意義. 中國普外基礎(chǔ)與臨床雜志, 2005, 12(4): 349-350. doi: 復(fù)制

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2. Sheppard MS, Minuk GY, Bhaumick B, et al. Insulinlike growth factors (IGF) in liver disease: differential changes of IGFⅠ and IGFⅡ [Ｊ]. Clin Invest Med, 1987; 10(2)∶49.
3. Priego T, Granado M, Ibanez de Caceres I, et al. Endotoxin at low doses stimulates pituitary GH whereas it decreases IGFⅠ and IGFbinding protein in rats [Ｊ]. J Endocrinol, 200; 179(1)∶107.
4. FernandezCelemin L, Pasko N, Blomart V, et al. Inhibition of muscle insulinlike growth factor Ⅰ expression by tumor necrosis factoralpha [Ｊ]. Am J Physiol Endocrinol Metab, 2002; 283(6)∶E1279.
5. Katz S, Pescovitz OH, Grosfeld JL. Growth failure and decreased levels of insulinlike growth factor Ⅰ in obstructive jaundice are reversed by bile diversion [Ｊ]. J Pediatr Surg, 1991; 26(8)∶900.
  1. 1. Moller S, Becker U. Insulinlike growth factor 1 and growth hormone in chronic liver disease [Ｊ]. Dig Dis， 1992; 10(4)∶239.
  2. 2. Sheppard MS, Minuk GY, Bhaumick B, et al. Insulinlike growth factors (IGF) in liver disease: differential changes of IGFⅠ and IGFⅡ [Ｊ]. Clin Invest Med, 1987; 10(2)∶49.
  3. 3. Priego T, Granado M, Ibanez de Caceres I, et al. Endotoxin at low doses stimulates pituitary GH whereas it decreases IGFⅠ and IGFbinding protein in rats [Ｊ]. J Endocrinol, 200; 179(1)∶107.
  4. 4. FernandezCelemin L, Pasko N, Blomart V, et al. Inhibition of muscle insulinlike growth factor Ⅰ expression by tumor necrosis factoralpha [Ｊ]. Am J Physiol Endocrinol Metab, 2002; 283(6)∶E1279.
  5. 5. Katz S, Pescovitz OH, Grosfeld JL. Growth failure and decreased levels of insulinlike growth factor Ⅰ in obstructive jaundice are reversed by bile diversion [Ｊ]. J Pediatr Surg, 1991; 26(8)∶900.