• 中南大學(xué)湘雅移植醫(yī)學(xué)研究院（長(zhǎng)沙410013）;

目的:總結(jié)肝移植圍手術(shù)期應(yīng)用分子吸附循環(huán)系統(tǒng)（MARS）人工肝的經(jīng)驗(yàn)。
方法:回顧分析19例48次MARS人工肝治療的療效。
結(jié)果:單次或多次MARS人工肝治療能顯著降低血清總膽紅素、間接膽紅素、血氨、尿素氮、肌酐、尿酸等水平。19例患者中15例成功過(guò)渡到肝移植治療； 1例因免疫抑制劑中毒經(jīng)MARS人工肝治療癥狀改善； 1例移植肝功能好轉(zhuǎn)； 1例晚期肝硬變患者治療后肝性腦病癥狀得到緩解，因各種原因不愿再行肝移植，出院后2周死亡； 1例患者因上消化道大出血未能等到肝移植而死亡。治療成功率為89.5%。
結(jié)論:MARS人工肝是治療肝功能衰竭安全而有效的輔助方法，為使患者能過(guò)渡到肝移植創(chuàng)造了機(jī)會(huì)。

引用本文： 明英姿,葉啟發(fā),袁金忠. MARS人工肝在肝移植圍手術(shù)期中的應(yīng)用. 中國(guó)普外基礎(chǔ)與臨床雜志, 2005, 12(2): 127-129下轉(zhuǎn)134. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國(guó)普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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  2. 2. Stange J, Mitzner S, Ramlow W, et al. A new procedure for the removal of protein bound drugs and toxins [Ｊ]. ASAIO J, 1993; 39(3)∶M621.
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  4. 4. Schmidt LE, Sorensen VR, Svendsen LB, et al. Hemodynamic changes during a single treatment with the molecular adsorbents recirculating system in patients with acuteonchronic liver failure [Ｊ]. Liver Transpl, 2001; 7(12)∶1034.
  5. 5. Schmidt LE, Svendsen LB, Sorensen VR, et al. Cerebral blood flow velocity increases during a single treatment with the molecular adsorbents recirculating system in patients with acute on chronic liver failure [Ｊ]. Liver Transpl, 2001; 7(8)∶709.
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