• 中國醫(yī)科大學(xué)附屬第一醫(yī)院腫瘤外科（沈陽110001）;;
  • 通訊作者： 戴冬秋， E-mail： daidq63@163.com;

目的　 探討腫瘤抑制基因甲基化與胃癌的關(guān)系。方法　對近年來關(guān)于腫瘤抑制基因甲基化與胃癌關(guān)系的文獻(xiàn)進行綜述分析。 結(jié)果　胃癌中，細(xì)胞周期調(diào)控基因、有絲分裂檢測點基因、凋亡相關(guān)基因、錯配修復(fù)基因、轉(zhuǎn)移相關(guān)基因等多種腫瘤抑制基因發(fā)生甲基化而失活。結(jié)論　腫瘤抑制基因甲基化在胃癌的發(fā)生、發(fā)展過程中起重要作用，腫瘤抑制基因的甲基化有可能成為胃癌診斷、判斷轉(zhuǎn)移和評價預(yù)后的分子標(biāo)記物，去甲基化干預(yù)有望成為胃癌治療的新方法。

引用本文： 楊少輝,戴冬秋. 腫瘤抑制基因甲基化與胃癌△. 中國普外基礎(chǔ)與臨床雜志, 2006, 13(5): 614-616. doi: 復(fù)制

1. 　Reik W, Dean W, Walter J. Epigenetic reprogramming in ma-mmalian development [J]. Science， 2001; 293(5532)∶1089.
2. 　Robertson KD, Jones PA. DNA methylation: past， present and future directions [J]. Carcinogenesis, 2000; 21(3)∶461.
3. 　Attwood JT, Yung RL, Richardson BC. DNA methylation and the regulation of gene transcription [J].Cell Mol Life Sci， 2002; 59(2)∶241.
4. 　Yan L, Yang X, Davidson NE. Role of DNA methylation and histone acetylation in steroid receptor expression in breast cancer [J]. J Mammary Gland Biol Neoplasia， 2001; 6(2)∶183.
5. 　Pfeifer GP, Tang M, Denissenko MF. Mutation hotspots and DNA methylation [J]. Curr Top Microbiol Immunol， 2000; 249（1）∶1.
6. 　Kang GH, Lee S, Kim JS, et al. Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis [J]. Lab Invest， 2003; 83(5)∶635.
7. 　Ding Y, Le XP, Zhang QX, et al. Methylation and mutation analysis of p16 gene in gastric cancer [J]. World J Gastroenterol， 2003; 9(3)∶423.
8. 　Lee JH, Park SJ, Abraham SC, et al. Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas [J]. Oncogene， 2004; 23(26)∶4646.
9. 　Lee TL, Leung WK, Chan MW, et al. Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma [J]. Clin Cancer Res， 2002; 8(6)∶1761.
10. 　Kang HC, Kim IJ, Park JH, et al. Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers [J]. Oncol Rep， 2004; 12(1)∶129.
11. 　Murai M, Toyota M, Suzuki H, et al. Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer [J]. Clin Cancer Res， 2005; 11(3)∶1021.
12. 　Jung HY, Jung KC, Shim YH, et al. Methylation of the hMLH1 promoter in multiple gastric carcinomas with microsatellite instability [J]. Pathol Int， 2001; 51(6)∶445.
13. 　Nakajima T, Akiyama Y, Shiraishi J, et al. Age-related hypermethylation of the hMLH1 promoter in gastric cancers [J]. Int J Cancer， 2001; 94(2)∶208.
14. 　Oue N, Shigeishi H, Kuniyasu H, et al. Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma [J]. Int J Cancer， 2001; 93(6)∶805.
15. 　Hong SH, Kim HG, Chung WB, et al. DNA hypermethylation of tumor-related genes in gastric carcinoma [J]. J Korean Med Sci， 2005; 20(2)∶236.
16. 　Hazan RB, Qiao R, Keren R, et al. Cadherin switch in tumor progression [J]. Ann N Y Acad Sci， 2004; 1014∶155.
17. 　鄭志紅， 孫秀菊， 邱廣蓉， 等. 胃癌癌前和發(fā)展階段中E-cadherin基因的突變 [J]. 世界華人消化雜志， 2002; 10（2）∶153.
18. 　鄭志紅， 孫秀菊， 馬鳴超， 等. 胃癌發(fā)展相關(guān)階段中E-cadherin基因啟動子甲基化及蛋白表達(dá)的研究 [J]. 遺傳學(xué)報， 2003; 30（2）∶103.
19. 　Santini V, Kantarjian HM, Issa JP. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications [J]. Ann Intern Med, 2001; 134(7)∶573.
  1. 1. 　Reik W, Dean W, Walter J. Epigenetic reprogramming in ma-mmalian development [J]. Science， 2001; 293(5532)∶1089.
  2. 2. 　Robertson KD, Jones PA. DNA methylation: past， present and future directions [J]. Carcinogenesis, 2000; 21(3)∶461.
  3. 3. 　Attwood JT, Yung RL, Richardson BC. DNA methylation and the regulation of gene transcription [J].Cell Mol Life Sci， 2002; 59(2)∶241.
  4. 4. 　Yan L, Yang X, Davidson NE. Role of DNA methylation and histone acetylation in steroid receptor expression in breast cancer [J]. J Mammary Gland Biol Neoplasia， 2001; 6(2)∶183.
  5. 5. 　Pfeifer GP, Tang M, Denissenko MF. Mutation hotspots and DNA methylation [J]. Curr Top Microbiol Immunol， 2000; 249（1）∶1.
  6. 6. 　Kang GH, Lee S, Kim JS, et al. Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis [J]. Lab Invest， 2003; 83(5)∶635.
  7. 7. 　Ding Y, Le XP, Zhang QX, et al. Methylation and mutation analysis of p16 gene in gastric cancer [J]. World J Gastroenterol， 2003; 9(3)∶423.
  8. 8. 　Lee JH, Park SJ, Abraham SC, et al. Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas [J]. Oncogene， 2004; 23(26)∶4646.
  9. 9. 　Lee TL, Leung WK, Chan MW, et al. Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma [J]. Clin Cancer Res， 2002; 8(6)∶1761.
  10. 10. 　Kang HC, Kim IJ, Park JH, et al. Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers [J]. Oncol Rep， 2004; 12(1)∶129.
  11. 11. 　Murai M, Toyota M, Suzuki H, et al. Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer [J]. Clin Cancer Res， 2005; 11(3)∶1021.
  12. 12. 　Jung HY, Jung KC, Shim YH, et al. Methylation of the hMLH1 promoter in multiple gastric carcinomas with microsatellite instability [J]. Pathol Int， 2001; 51(6)∶445.
  13. 13. 　Nakajima T, Akiyama Y, Shiraishi J, et al. Age-related hypermethylation of the hMLH1 promoter in gastric cancers [J]. Int J Cancer， 2001; 94(2)∶208.
  14. 14. 　Oue N, Shigeishi H, Kuniyasu H, et al. Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma [J]. Int J Cancer， 2001; 93(6)∶805.
  15. 15. 　Hong SH, Kim HG, Chung WB, et al. DNA hypermethylation of tumor-related genes in gastric carcinoma [J]. J Korean Med Sci， 2005; 20(2)∶236.
  16. 16. 　Hazan RB, Qiao R, Keren R, et al. Cadherin switch in tumor progression [J]. Ann N Y Acad Sci， 2004; 1014∶155.
  17. 17. 　鄭志紅， 孫秀菊， 邱廣蓉， 等. 胃癌癌前和發(fā)展階段中E-cadherin基因的突變 [J]. 世界華人消化雜志， 2002; 10（2）∶153.
  18. 18. 　鄭志紅， 孫秀菊， 馬鳴超， 等. 胃癌發(fā)展相關(guān)階段中E-cadherin基因啟動子甲基化及蛋白表達(dá)的研究 [J]. 遺傳學(xué)報， 2003; 30（2）∶103.
  19. 19. 　Santini V, Kantarjian HM, Issa JP. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications [J]. Ann Intern Med, 2001; 134(7)∶573.