• 華中科技大學同濟醫(yī)學院附屬協(xié)和醫(yī)院普外科（武漢 430022）;

目的　研究環(huán)氧合酶-2（cyclooxygenase-2，Cox-2）及血管生成素-2 (angiopoietin-2,Ang-2)在大腸癌組織、癌旁組織及正常大腸組織中的表達及其與大腸癌臨床病理特征之間的關系。方法　采用免疫組化SP法檢測45例大腸癌組織、45例癌旁組織及15例正常大腸組織中Cox-2和Ang-2的表達情況。 結(jié)果　大腸癌組織中的Cox-2和 Ang-2的表達陽性率(80.0%,66.7%)均分別高于癌旁組織(35.6%,11.1%)及正常大腸組織(0,0)，P均＜0.01。在大腸癌組織中Cox-2和Ang-2蛋白表達與淋巴結(jié)轉(zhuǎn)移及Dukes分期有關(P＜0.05),且二者的表達具有相關性(P＜0.01)。結(jié)論　Cox-2和Ang-2在大腸癌發(fā)生、發(fā)展中起重要作用，二者在表達上密切相關。

引用本文： 張寧,陶凱雄,王國斌,田元. 環(huán)氧合酶-2及血管生成素-2在大腸癌中的表達及臨床意義△. 中國普外基礎與臨床雜志, 2006, 13(5): 564-567. doi: 復制

版權(quán)信息： ?四川大學華西醫(yī)院華西期刊社《中國普外基礎與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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  1. 1. 　Ozdemir E, Kakehi Y, Okuno H, et al. Role of matrix metalloproteinase-9 in the basement membrane destruction of superficial urothelial carcinomas [J]. J Urol, 1999; 161(4)∶1359.
  2. 2. 　Oshima M, Dinchuk JE, Kargman SL, et al. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2) [J]. Cell， 1996; 87(5)∶803.
  3. 3. 　Seno H, Oshima M, Ishikawa TO, et al. Cyclooxygenase 2-and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps [J]. Cancer Res, 2002; 62(2)∶506.
  4. 4. 　Yancopoulos GD, Davis S, Gale NW, et al. Vascular-specific growth factors and blood vessel formation [J]. Nature, 2000; 407(6801)∶242.
  5. 5. 　Smith TJ. Cyclooxygenases as the principal targets for the actions of NSAIDs [J]. Rheum Dis Clin North Am, 1998; 24(3)∶501.
  6. 6. 　Sinicrope FA, Gill S. Role of cyclooxygenase-2 in colorectal cancer [J]. Cancer Metastasis Rev, 2004; 23(1-2)∶63.
  7. 7. 　 Ahmad SA, Liu W, Jung YD, et al. Differential expression of angiopoietin-1 and angiopoietin-2 in colon carcinoma. A possible mechanism for the initiation of angiogenesis [J]. Cancer, 2001; 92(5)∶1138.
  8. 8. 　Tsujii M, Kawano S, Tsuji S, et al.Cyclooxygenase regulates angiogenesis induced by colon cancer cells [J]. Cell, 1998; 93(5)∶705.
  9. 9. 　Williams CS, Tsujii M, Reese J, et al.Host cyclooxygenase-2 modulates carcinoma growth [J]. J Clin Invest, 2000; 105(11)∶1511.
  10. 10. 　Papapetropoulos A, Fulton D, Mahboubi K, et al. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway [J]. J Biol Chem, 2000; 275(13)∶9102.
  11. 11. 　Witzenbichler B, Maisonpierre PC, Jones P, et al. Chemotactic properties of angiopoietin-1 and-2, ligands for the endothelial-specific receptor tyrosine kinase Tie2 [J]. J Biol Chem， 1998; 273(29)∶18514.
  12. 12. 　Thurston G, Suri C, Smith K, et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1 [J]. Science， 1999; 286(5449)∶2511.