目的介紹內(nèi)源性血管生成抑制因子(內(nèi)皮抑素、血管抑素)在肝癌治療中的作用和意義。
方法復習相關(guān)文獻資料并作綜述性報道。
結(jié)果內(nèi)源性血管生成抑制因子通過抑制腫瘤血管的生長,有效地阻礙了肝癌的發(fā)展和轉(zhuǎn)移,可為臨床肝癌治療提供新的途徑。
結(jié)論應用內(nèi)源性血管生成抑制因子的研究,對肝癌的防治將有積極的意義。
引用本文: 鄧靖宇,何生. 內(nèi)源性血管生成抑制因子的研究進展及在肝癌中的應用前景. 中國普外基礎與臨床雜志, 2006, 13(2): 184-186. doi: 復制
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2. | Yancopoulos GD, Davis S, Gale NW, et al. Vascularspecific growth factors and blood vessel formation [J]. Nature, 2000; 407(6801)∶242. |
3. | Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis [J]. Cell, 1996; 86(3)∶353. |
4. | Iwasaki T, Hamano T, Ogata A, et al. Clinical significance of vascular endothelial growth factor and hepatocyte growth factor in multiple myeloma [J]. Br J Haematol, 2002; 116(4)∶796. |
5. | 侯恩存. 腫瘤血管生成與抗血管生成治療 [J]. 中國腫瘤臨床與康復, 2003; 10(2)∶179. |
6. | 過邦輔, 凌勵立. 血管生成和蛋白酶在腫瘤侵襲中的作用 [J]. 中國腫瘤, 1999; 8(4)∶177. |
7. | 王成偉, 寵琦, 張慶林. 血管生成與腫瘤的生長及轉(zhuǎn)移 [J]. 國外醫(yī)學·腫瘤學分冊, 2001; 28(2)∶118. |
8. | Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease [J]. Nat Med, 1995; 1(1)∶27. |
9. | 駱成玉, 祝學光. 腫瘤血管生成對微轉(zhuǎn)移影響的研究進展 [J]. 中國普外基礎與臨床雜志, 2003; 10(5)∶516. |
10. | Thaloor D, Singh AK, Sidhu GS, et al. Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin [J]. Cell Growth Differ, 1998; 9(4)∶305. |
11. | Folkman J. What is the evidence that tumors are angiogenesis dependent? [J]. J Natl Cancer Inst, 1990; 82(1)∶4. |
12. | 顏春洪, 韓銳. 抗惡性腫瘤轉(zhuǎn)移藥研究進展 [A]. 見: 曹世龍主編.腫瘤學新理論與新技術(shù) [M]. 上海: 上??萍冀逃霭嫔纾?1997∶462~484. |
13. | Claffey KP, Robinson GS. Regulation of VEGF/VPF expression in tumor cells: consequences for tumor growth and metastasis [J]. Cancer Metastasis Rev, 1996; 15(2)∶165. |
14. | Merwin RM, Algire GH. The role of graft and host vessels in the vascularization of grafts of normal and neoplastic tissue [J]. J Natl Cancer Inst, 1956; 17(1)∶23. |
15. | Taylor S, Folkman J. Protamine is an inhibitor of angiogenesis [J]. Nature, 1982; 297(5864)∶307. |
16. | 后信, 桑野信彥. か轉(zhuǎn)移阻止開發(fā)口一千 [J]. 日本癌癥治療, 1995; 30(5)∶713. |
17. | Saphir A. Angiogenesis: the unifying concept in cancer? [J]. J Natl Cancer Inst, 1997; 89(22)∶1658. |
18. | Burke PA, DeNardo SJ. Antiangiogenic agents and their promising potential in combined therapy [J]. Crit Rev Oncol Hematol, 2001; 39(1-2)∶155. |
19. | 王貴齊. 腫瘤與血管 [J]. 中國腫瘤臨床, 1995; 22(10)∶743. |
20. | Cao Y, Ji RW, Davidson D, et al. Kringle domains of human angiostatin. Characterization of the antiproliferative activity on endothelial cells [J]. J Biol Chem, 1996; 271(46)∶29461. |
21. | Cao Y, Chen A, An SS, et al. Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth [J]. J Biol Chem, 1997; 272(36)∶22924. |
22. | Luo J, Lin J, Paranya G, et al. Angiostatin upregulates Eselectin in proliferating endothelial cells [J]. Biochem Biophys Res Commun, 1998; 245(3)∶906. |
23. | Ito H, Rovira II, Bloom ML, et al. Endothelial progenitor cells as putative targets for angiostatin [J]. Cancer Res, 1999; 59(23)∶5875. |
24. | Standker L, Schrader M, Kanse SM, et al. Isolation and characterization of the circulating form of human endostatin [J]. FEBS Lett, 1997; 420(2-3)∶129. |
25. | Schuppan D, Cramer T, Bauer M, et al. Hepatocytes as a source of collagen type ⅩⅧ endostatin [J]. Lancet, 1998; 352(9131)∶879. |
26. | He ZY, Chen ZY, Qiu CP, et al. Cloning, expression and tamor suppression of human endostatin [J]. Acta Biochemica and Biophysica Sinica, 2000; 32(4)∶333. |
27. | Felbor U, Dreier L, Bryant RA, et al. Secreted cathepsin L generates endostatin from collagen ⅩⅧ [J]. EMBO J, 2000; 19(6)∶1187. |
28. | 王軒, 劉福坤, 黎介壽. 血管內(nèi)皮抑制素的研究進展 [J]. 臨床腫瘤學雜志, 2001; 6(3)∶287. |
29. | Dixelius J, Larsson H, Sasaki T, et al. Endostatininduced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis [J]. Blood, 2000; 95(11)∶3403. |
30. | Yamaguchi N, AnandApte B, Lee M, et al. Endostatin inhibits VEGFinduced endothelial cell migration and tumor growth independently of zinc binding [J]. EMBO J, 1999; 18(16)∶4414. |
31. | Dhanabal M, Volk R, Ramchandran R, et al. Cloning, expression, and in vitro activity of human endostatin [J]. Biochem Biophys Res Commun, 1999; 258(2)∶345. |
32. | Hohenester E, Sasaki T, Mann K, et al. Variable zinc coordination in endostatin [J]. J Mol Biol, 2000; 297(1)∶1. |
33. | Perletti G, Concari P, Giardini R, et al. Antitumor activity of endostatin against carcinogeninduced rat primary mammary tumors [J]. Cancer Res, 2000; 60(7)∶1793. |
34. | 孫惠川, 湯釗猷, 王魯. Endostatin抑制裸鼠移植性肝癌切除后的復發(fā)移植 [J]. 中華腫瘤雜志, 2000; 22(6)∶469. |
35. | Folkman J. Antiangiogenic gene therapy [J]. Proc Natl Acad Sci USA, 1998; 95(16)∶9064. |
36. | Teicher BA, Holden SA, Ara G, et al. Potentiation of cytotoxic cancer therapies by TNP470 alone and with other antiangiogenic agents [J]. Int J Cancer, 1994; 57(6)∶920. |
- 1. Folkman J. Tumor angiogenesis: therapeutic implications [J]. N Engl J Med, 1971; 285(21)∶1182.
- 2. Yancopoulos GD, Davis S, Gale NW, et al. Vascularspecific growth factors and blood vessel formation [J]. Nature, 2000; 407(6801)∶242.
- 3. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis [J]. Cell, 1996; 86(3)∶353.
- 4. Iwasaki T, Hamano T, Ogata A, et al. Clinical significance of vascular endothelial growth factor and hepatocyte growth factor in multiple myeloma [J]. Br J Haematol, 2002; 116(4)∶796.
- 5. 侯恩存. 腫瘤血管生成與抗血管生成治療 [J]. 中國腫瘤臨床與康復, 2003; 10(2)∶179.
- 6. 過邦輔, 凌勵立. 血管生成和蛋白酶在腫瘤侵襲中的作用 [J]. 中國腫瘤, 1999; 8(4)∶177.
- 7. 王成偉, 寵琦, 張慶林. 血管生成與腫瘤的生長及轉(zhuǎn)移 [J]. 國外醫(yī)學·腫瘤學分冊, 2001; 28(2)∶118.
- 8. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease [J]. Nat Med, 1995; 1(1)∶27.
- 9. 駱成玉, 祝學光. 腫瘤血管生成對微轉(zhuǎn)移影響的研究進展 [J]. 中國普外基礎與臨床雜志, 2003; 10(5)∶516.
- 10. Thaloor D, Singh AK, Sidhu GS, et al. Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin [J]. Cell Growth Differ, 1998; 9(4)∶305.
- 11. Folkman J. What is the evidence that tumors are angiogenesis dependent? [J]. J Natl Cancer Inst, 1990; 82(1)∶4.
- 12. 顏春洪, 韓銳. 抗惡性腫瘤轉(zhuǎn)移藥研究進展 [A]. 見: 曹世龍主編.腫瘤學新理論與新技術(shù) [M]. 上海: 上??萍冀逃霭嫔?, 1997∶462~484.
- 13. Claffey KP, Robinson GS. Regulation of VEGF/VPF expression in tumor cells: consequences for tumor growth and metastasis [J]. Cancer Metastasis Rev, 1996; 15(2)∶165.
- 14. Merwin RM, Algire GH. The role of graft and host vessels in the vascularization of grafts of normal and neoplastic tissue [J]. J Natl Cancer Inst, 1956; 17(1)∶23.
- 15. Taylor S, Folkman J. Protamine is an inhibitor of angiogenesis [J]. Nature, 1982; 297(5864)∶307.
- 16. 后信, 桑野信彥. か轉(zhuǎn)移阻止開發(fā)口一千 [J]. 日本癌癥治療, 1995; 30(5)∶713.
- 17. Saphir A. Angiogenesis: the unifying concept in cancer? [J]. J Natl Cancer Inst, 1997; 89(22)∶1658.
- 18. Burke PA, DeNardo SJ. Antiangiogenic agents and their promising potential in combined therapy [J]. Crit Rev Oncol Hematol, 2001; 39(1-2)∶155.
- 19. 王貴齊. 腫瘤與血管 [J]. 中國腫瘤臨床, 1995; 22(10)∶743.
- 20. Cao Y, Ji RW, Davidson D, et al. Kringle domains of human angiostatin. Characterization of the antiproliferative activity on endothelial cells [J]. J Biol Chem, 1996; 271(46)∶29461.
- 21. Cao Y, Chen A, An SS, et al. Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth [J]. J Biol Chem, 1997; 272(36)∶22924.
- 22. Luo J, Lin J, Paranya G, et al. Angiostatin upregulates Eselectin in proliferating endothelial cells [J]. Biochem Biophys Res Commun, 1998; 245(3)∶906.
- 23. Ito H, Rovira II, Bloom ML, et al. Endothelial progenitor cells as putative targets for angiostatin [J]. Cancer Res, 1999; 59(23)∶5875.
- 24. Standker L, Schrader M, Kanse SM, et al. Isolation and characterization of the circulating form of human endostatin [J]. FEBS Lett, 1997; 420(2-3)∶129.
- 25. Schuppan D, Cramer T, Bauer M, et al. Hepatocytes as a source of collagen type ⅩⅧ endostatin [J]. Lancet, 1998; 352(9131)∶879.
- 26. He ZY, Chen ZY, Qiu CP, et al. Cloning, expression and tamor suppression of human endostatin [J]. Acta Biochemica and Biophysica Sinica, 2000; 32(4)∶333.
- 27. Felbor U, Dreier L, Bryant RA, et al. Secreted cathepsin L generates endostatin from collagen ⅩⅧ [J]. EMBO J, 2000; 19(6)∶1187.
- 28. 王軒, 劉福坤, 黎介壽. 血管內(nèi)皮抑制素的研究進展 [J]. 臨床腫瘤學雜志, 2001; 6(3)∶287.
- 29. Dixelius J, Larsson H, Sasaki T, et al. Endostatininduced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis [J]. Blood, 2000; 95(11)∶3403.
- 30. Yamaguchi N, AnandApte B, Lee M, et al. Endostatin inhibits VEGFinduced endothelial cell migration and tumor growth independently of zinc binding [J]. EMBO J, 1999; 18(16)∶4414.
- 31. Dhanabal M, Volk R, Ramchandran R, et al. Cloning, expression, and in vitro activity of human endostatin [J]. Biochem Biophys Res Commun, 1999; 258(2)∶345.
- 32. Hohenester E, Sasaki T, Mann K, et al. Variable zinc coordination in endostatin [J]. J Mol Biol, 2000; 297(1)∶1.
- 33. Perletti G, Concari P, Giardini R, et al. Antitumor activity of endostatin against carcinogeninduced rat primary mammary tumors [J]. Cancer Res, 2000; 60(7)∶1793.
- 34. 孫惠川, 湯釗猷, 王魯. Endostatin抑制裸鼠移植性肝癌切除后的復發(fā)移植 [J]. 中華腫瘤雜志, 2000; 22(6)∶469.
- 35. Folkman J. Antiangiogenic gene therapy [J]. Proc Natl Acad Sci USA, 1998; 95(16)∶9064.
- 36. Teicher BA, Holden SA, Ara G, et al. Potentiation of cytotoxic cancer therapies by TNP470 alone and with other antiangiogenic agents [J]. Int J Cancer, 1994; 57(6)∶920.