目的 總結(jié)分析殘胃癌的臨床病理學(xué)特征。
方法 回顧性分析2000年3月至2008年5月期間川北醫(yī)學(xué)院附屬第二醫(yī)院和中國人民解放軍總醫(yī)院共114例殘胃癌的臨床病理學(xué)資料。依據(jù)原發(fā)疾病性質(zhì)分為良性疾病組和惡性疾病組進(jìn)行分析。
結(jié)果 本組114例患者,年齡(62.6±11.3)歲,男∶女=4.7∶1.0。76.2% (64/84)的患者診斷時處于進(jìn)展期(以pT分期為依據(jù)),pT1期病例僅占23.8%(20/84),60.7%(51/84)的病例達(dá)pT4期。殘胃癌的一般病理特征:pT4b(27.4%,23/84)、pN+(42.9%,36/84)及cM1(27.2%,31/114)常見,93.5%(29/31)的遠(yuǎn)處轉(zhuǎn)移位于腹腔,腹膜轉(zhuǎn)移最高達(dá)67.7%(21/31)。組織學(xué)分化程度以低分化腺癌最常見(76.7%,79/103),Laurén分型以彌漫型最常見(78.6%,81/103)。良、惡性原發(fā)疾病間首次采用的手術(shù)方式和重建方式差異均有統(tǒng)計學(xué)意義(均P=0.000)。中位發(fā)病時間(潛伏期)良性組∶惡性組=30.0年∶3.3年(P=0.000),主要受原發(fā)疾病性質(zhì)、首次手術(shù)時年齡的影響(P<0.05)。良、惡性組間的病理學(xué)指標(biāo)比較,除是否為印戒細(xì)胞癌(P=0.045)、是否侵犯周圍臟器(P=0.049)、pN分期(P=0.025)及Borrmann分型(P=0.005) 差異有統(tǒng)計學(xué)意義外,其余病理學(xué)指標(biāo)以及手術(shù)切除率、R0切除率和生存率差異均無統(tǒng)計學(xué)意義(P>0.05)。
結(jié)論 殘胃癌的主要臨床病理學(xué)特征基本上不受原發(fā)疾病性質(zhì)的影響,建立個體化的內(nèi)鏡隨訪程序是必要和可行的。
引用本文: 肖仕明,陳凜,彭正,姜淮蕪,彭方興,陳進(jìn),吳宸,劉君,羅亮. 殘胃癌的臨床病理學(xué)特征分析(附114例報道). 中國普外基礎(chǔ)與臨床雜志, 2012, 19(11): 1191-1199. doi: 復(fù)制
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2. | Park JH, Lee JH, Rhee PL, et al. Endoscopic screening for remnant gastric cancer:points to be considered[J]. Gut Liver, 2007, 1(1):22-26. |
3. | Mezhir JJ, Gonen M, Ammori JB, et al. Treatment and outcome of patients with gastric remnant cancer after resection for peptic ulcer disease[J]. Ann Surg Oncol, 2011, 18(3):670-676. |
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7. | 胡祥. 第14版日本《胃癌處理規(guī)約》的重要變更[J]. 中國實用外科雜志, 2010, 30(4):241-246. |
8. | 鐘曉剛, 殷舞, 麥威, 等. 殘胃癌外科治療臨床分析及再認(rèn)識[J]. 中國普外基礎(chǔ)與臨床雜志, 2012, 19(1):20-24. |
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12. | JGCA. Japanese classification of gastric carcinoma-2nd English edition[J]. Gastric Cancer, 1998, 1(1):10-24. |
13. | Townsend CM, Beauchamp RD, Evers BM, et al. Sabiston textbook of surgery[M]. 18th ed. Saunders/Elsevier, 2007. |
14. | An JY, Youn HG, Ha TK, et al. Clinical significance of tumor location in remnant gastric cancers developed after partial gastrectomy for primary gastric cancer[J]. J Gastrointest Surg, 2008, 12(4):689-694. |
15. | Hottenrott C. Remnant gastric cancer:can the risk be predicted when planning initial surgery?[J]. World J Surg, 2011, 35(2):462-463. |
16. | Firat O, Guler A, Sozbilen M, et al. Gastric remnant cancer:an old problem with novel concerns[J]. Langenbecks Arch Surg, 2009, 394(1):93-97. |
17. | 周立新, 張則偉, 徐志遠(yuǎn). 殘胃癌的外科治療與預(yù)后分析[J]. 癌癥, 2009, 28(5):511-514. |
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22. | Ohashi M, Katai H, Fukagawa T, et al. Cancer of the gastric stump following distal gastrectomy for cancer[J]. Br J Surg, 2007, 94(1):92-95. |
23. | Ohyama S, Tokunaga M, Hiki N, et al. A clinicopathological study of gastric stump carcinoma following proximal gastrectomy[J]. Gastric Cancer, 2009, 12(2):88-94. |
24. | Nunobe S, Ohyama S, Miyata S, et al. Incidence of gastric cancer in the remnant stomach after proximal gastrectomy[J]. Hepatogastroenterology, 2008, 55(86-87):1855-1858. |
25. | 聶明明, 申曉軍, 魏國, 等. 殘胃癌的臨床病理特征及預(yù)后52例分析[J/OL]. 中華普外科手術(shù)學(xué)雜志(電子版), 2010, 4(2):144-148. |
26. | Hu X, Tian DY, Cao L, et al. Progression and prognosis of gastricstump cancer[J]. J Surg Oncol, 2009, 100(6):472-476. |
27. | 李昉璇, 張汝鵬, 趙敬柱, 等. 殘胃癌臨床病理特征與預(yù)后因素分析[J]. 中華外科雜志, 2011, 49(3):204-207. |
- 1. Tanigawa N, Nomura E, Lee SW, et al. Current state of gastric stump carcinoma in Japan:based on the results of a nationwide survey[J]. World J Surg, 2010, 34(7):1540-1547.
- 2. Park JH, Lee JH, Rhee PL, et al. Endoscopic screening for remnant gastric cancer:points to be considered[J]. Gut Liver, 2007, 1(1):22-26.
- 3. Mezhir JJ, Gonen M, Ammori JB, et al. Treatment and outcome of patients with gastric remnant cancer after resection for peptic ulcer disease[J]. Ann Surg Oncol, 2011, 18(3):670-676.
- 4. Nozaki I, Nasu J, Kubo Y,et al. Risk factors for metachronous gastric cancer in the remnant stomach after early cancer surgery[J]. World J Surg, 2010, 34(7):1548-1554.
- 5. 陳凜, 王寧. 殘胃癌的流行病學(xué)及預(yù)防有關(guān)問題[J]. 中國實用外科雜志, 2009, 29(10):806-807.
- 6. Ahn HS, Kim JW, Yoo MW, et al. Clinicopathological features and surgical outcomes of patients with remnant gastric cancer after a distal gastrectomy [J]. Ann Surg Oncol, 2008, 15(6):1632-1639.
- 7. 胡祥. 第14版日本《胃癌處理規(guī)約》的重要變更[J]. 中國實用外科雜志, 2010, 30(4):241-246.
- 8. 鐘曉剛, 殷舞, 麥威, 等. 殘胃癌外科治療臨床分析及再認(rèn)識[J]. 中國普外基礎(chǔ)與臨床雜志, 2012, 19(1):20-24.
- 9. Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma:3rd English edition[J]. Gastric Cancer, 2011, 14(2):101-112.
- 10. Sobin LH, Gospodarowicz MK, Wittekind C. TNM classification of malignant tumours[M]. 7th ed:Wiley-Blackwell, 2009.
- 11. Washington K, Berlin J, Branton P, et al. Protocol for the examination of specimens from patients with carcinoma of the stomach[DB/OL]. Stomach 3. 1. 0. 0 ed. College of American Pathologists, 2011. www. cap. org/cancerprotocols.
- 12. JGCA. Japanese classification of gastric carcinoma-2nd English edition[J]. Gastric Cancer, 1998, 1(1):10-24.
- 13. Townsend CM, Beauchamp RD, Evers BM, et al. Sabiston textbook of surgery[M]. 18th ed. Saunders/Elsevier, 2007.
- 14. An JY, Youn HG, Ha TK, et al. Clinical significance of tumor location in remnant gastric cancers developed after partial gastrectomy for primary gastric cancer[J]. J Gastrointest Surg, 2008, 12(4):689-694.
- 15. Hottenrott C. Remnant gastric cancer:can the risk be predicted when planning initial surgery?[J]. World J Surg, 2011, 35(2):462-463.
- 16. Firat O, Guler A, Sozbilen M, et al. Gastric remnant cancer:an old problem with novel concerns[J]. Langenbecks Arch Surg, 2009, 394(1):93-97.
- 17. 周立新, 張則偉, 徐志遠(yuǎn). 殘胃癌的外科治療與預(yù)后分析[J]. 癌癥, 2009, 28(5):511-514.
- 18. Thorban S, Böttcher K,Etter M, et al. Prognostic factors in gastric stump carcinoma[J]. Ann Surg, 2000, 231(2):188-194.
- 19. Takeno S, Noguchi T, Kimura Y, et al. Early and late gastric cancer arising in the remnant stomach after distal gastrectomy[J]. Eur J Surg Oncol, 2006, 32(10):1191-1194.
- 20. Tanigawa N,Nomura E, Niki M, et al. Clinical study to identify specific characteristics of cancer newly developed in the remnant stomach[J]. Gastric Cancer, 2002, 5(1):23-28.
- 21. Seoane A, Bessa X, Alameda F, et al. Role of helicobacter pyloriin stomach cancer after partial gastrectomy for benign ulcerdisease[J]. Rev Esp Enferm Dig, 2005, 97(11):778-785.
- 22. Ohashi M, Katai H, Fukagawa T, et al. Cancer of the gastric stump following distal gastrectomy for cancer[J]. Br J Surg, 2007, 94(1):92-95.
- 23. Ohyama S, Tokunaga M, Hiki N, et al. A clinicopathological study of gastric stump carcinoma following proximal gastrectomy[J]. Gastric Cancer, 2009, 12(2):88-94.
- 24. Nunobe S, Ohyama S, Miyata S, et al. Incidence of gastric cancer in the remnant stomach after proximal gastrectomy[J]. Hepatogastroenterology, 2008, 55(86-87):1855-1858.
- 25. 聶明明, 申曉軍, 魏國, 等. 殘胃癌的臨床病理特征及預(yù)后52例分析[J/OL]. 中華普外科手術(shù)學(xué)雜志(電子版), 2010, 4(2):144-148.
- 26. Hu X, Tian DY, Cao L, et al. Progression and prognosis of gastricstump cancer[J]. J Surg Oncol, 2009, 100(6):472-476.
- 27. 李昉璇, 張汝鵬, 趙敬柱, 等. 殘胃癌臨床病理特征與預(yù)后因素分析[J]. 中華外科雜志, 2011, 49(3):204-207.