目的 總結(jié)目前對(duì)妊娠期乳腺癌診斷與治療的相關(guān)研究，為妊娠期乳腺癌的診斷與治療提供參考依據(jù)。
方法 應(yīng)用PubMed、Medline和CNKI以“妊娠期乳腺癌、妊娠期乳腺癌的診斷、妊娠期乳腺癌的治療”等為關(guān)鍵詞，檢索關(guān)于妊娠期乳腺癌的診斷與治療的相關(guān)文獻(xiàn)并進(jìn)行綜述。
結(jié)果 妊娠期乳腺癌的診斷手段包括彩超、鉬靶、核磁共振、穿刺活檢等，其治療包括了手術(shù)治療、化學(xué)治療、內(nèi)分泌治療、放射治療、靶向治療。但是診斷和治療手段的使用要考慮到是否對(duì)妊娠患者及胎兒的影響。
結(jié)論 通過(guò)對(duì)相關(guān)妊娠期乳腺癌診斷和治療的研究分析，可以為妊娠期乳腺癌患者妊娠提供安全且合理的診斷和治療措施，貝伐單抗及拉帕替尼在妊娠期乳腺癌治療中的使用有待進(jìn)一步研究。
引用本文： 黃元坤,周蕾蕾. 妊娠期乳腺癌的診斷和治療現(xiàn)狀. 中國(guó)普外基礎(chǔ)與臨床雜志, 2013, 20(8): 862-866. doi: 復(fù)制
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| 16. | Gentilini O， Cremonesi M， Toesca A， et al. Sentinel lymph node biopsy in pregnant patients with breast cancer[J]. Eur J Nucl Med Mol Imaging， 2010， 37(1)：78-83. |
| 17. | Khera SY， Kiluk JV， Hasson DM， et al. Pregnancy-associated breast cancer patients can safely undergo lymphatic mapping[J]. Breast J， 2008， 14(3)：250-254. |
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- 1. Pentheroudakis G， Orecchia R， Hoekstra HJ， et al. Cancer， fertility and pregnancy：ESMO Clinical Practice Guidelines for diagnosis， treatment and follow-up[J]. Ann Oncol， 2010， 21 Suppl 5：v266-v273.
- 2. Middleton LP， Amin M， Gwyn K， et al. Breast carcinoma in pregnant women：assessment of clinicopathologic and immunohistochemical features[J]. Cancer， 2003， 98(5)：1055-1060.
- 3. Bonnier P， Romain S， Dilhuydy JM， et al. Influence of pregnancy on the outcome of breast cancer：a case-control study. Societe Francaise de Senologie et de Pathologie Mammaire Study Group[J]. Int J Cancer， 1997， 72(5)：720-727.
- 4. Greskovich JF， Macklis RM. Radiation therapy in pregnancy：risk calculation and risk minimization[J]. Semin Oncol， 2000， 27(6)：633-645.
- 5. Osei EK， Faulkner K. Fetal doses from radiological examinations[J]. Br J Radiol， 1999， 72(860)： 773-780.
- 6. Yang WT， Dryden MJ， Gwyn K， et al. Imaging of breast cancer diagnosed and treated with chemotherapy during pregnancy[J]. Radiology， 2006， 239(1)：52-60.
- 7. 沈鎮(zhèn)宙， 邵志敏. 乳腺腫瘤學(xué)[M]. 上海：上?？茖W(xué)技術(shù)出版社， 2005： 92 -121.
- 8. Vashi R， Hooley R， Butler R， et al. Breast imaging of the pregnant and lactating patient：imaging modalities and pregnancy-asso-ciated breast cancer[J]. AJR Am J Roentgenol， 2013， 200(2)：321-328.
- 9. NCCN Clinical Practice Guidelines in Oncology. Breast cancer[EB/OL]. Version 2. 2012. Available online：http：//www. nccn.com.
- 10. Rovera F， Frattini F， Coglitore A， et al. Breast cancer in pregnancy[J]. Breast J， 2010， 16 Suppl 1：S22-S25.
- 11. Molckovsky A， Madarnas Y. Breast cancer in pregnancy：a literature review [J]. Breast Cancer Res Treat， 2008， 108(3)：333-338.
- 12. Navrozoglou I， Vrekoussis T， Kontostolis E， et al. Breast cancer during pregnancy：a mini-review[J]. Eur J Surg Oncol， 2008， 34(8)：837-843.
- 13. Vinatier E， Merlot B， Poncelet E， et al. Breast cancer duringpregnancy[J]. Eur J Obstet Gynecol Reprod Biol， 2009， 147(1)：9-14.
- 14. Amant F， Loibl S， Neven P， et al. Breast cancer in pregnancy[J]. Lancet， 2012， 379(9815)：570-579.
- 15. Gentilini O， Cremonesi M， Trifirò G， et al. Safety of sentinel node biopsy in pregnant patients with breast cancer[J]. Ann Oncol， 2004， 15(9)：1348-1351.
- 16. Gentilini O， Cremonesi M， Toesca A， et al. Sentinel lymph node biopsy in pregnant patients with breast cancer[J]. Eur J Nucl Med Mol Imaging， 2010， 37(1)：78-83.
- 17. Khera SY， Kiluk JV， Hasson DM， et al. Pregnancy-associated breast cancer patients can safely undergo lymphatic mapping[J]. Breast J， 2008， 14(3)：250-254.
- 18. Azim H Jr， Gentilini O， Locatelli M， et al. Managing pregnant women with cancer：personal considerations and a review of the literature[J]. Ecancermedicalscience， 2011， 5：204.
- 19. Behrman RH， Homer MJ， Yang WT， et al. Mammography and fetal dose[J]. Radiology， 2007， 243(2)：605-606.
- 20. Martin DD. Review of radiation therapy in the pregnant cancer patient[J]. Clin Obstet Gynecol， 2011， 54(4)：591-601.
- 21. Guidroz JA， Scott-Conner CE， Weigel RJ. Management of pregnant women with breast cancer[J]. Surg Oncol， 2011， 103(4)：337-340.
- 22. Amant F， Deckers S， Van Calsteren K， et al. Breast cancer in pregnancy：recommendations of an international consensus meeting[J]. Eur J Cancer， 2010， 46(18)：3158-3168.
- 23. Ring AE， Smith IE， Jones A， et al. Chemotherapy for breast cancer during pregnancy：an 18-year experience from five Londonteaching hospitals[J]. Clin Oncol， 2005， 23(18)：4192-4197.
- 24. Hahn KM， Johnson PH， Gordon N， et al. Treatment of pregnantbreast cancer patients and outcomes of children exposed to chemo-therapy in utero[J]. Cancer， 2006， 107(6)：1219-1226.
- 25. Azim HA Jr， Peccatori FA， Pavlidis N. Treatment of the pregnantmother with cancer：a systematic review on the use of cytotoxic， endocrine， targeted agents and immunotherapy during pregnancy. PartⅠ：Solid tumors[J]. Cancer Treat Rev， 2010， 36(2)：101-109.
- 26. Loibl S， von Minckwitz G， Gwyn K， et al. Breast carcinoma during pregnancy. International recommendations from an expert meeting[J]. Cancer， 2006， 106(2)：237-246.
- 27. Zagouri F， Sergentanis TN， Chrysikos D， et al. Taxanes for breast cancer during pregnancy：a systematic review[J]. Clin Breast Cancer， 2013， 13(1)：16-23.
- 28. Cardonick E， Bhat A， Gilmandyar D， et al. Maternal and fetal outcomes of taxane chemotherapy in breast and ovarian cancer during pregnancy：case series and review of the literature[J]. Ann Oncol， 2012， 23(12)：3016-3023.
- 29. Berveiller P， Mir O. Taxanes during pregnancy：probably safe， but still to be optimized[J]. Oncology， 2012， 83(4)：239-240.
- 30. Azim HA， Del Mastro L， Scarfone G， et al. Treatment of breast cancer during pregnancy：regimen selection， pregnancy monitoringand more[J]. Breast， 2011， 20(1)：1-6.
- 31. Azim HA， Azim H， Peccatori FA. Treatment of cancer during pregnancy with monoclonal antibodies：a real challenge[J]. Expert Rev Clin Immunol， 2010， 6(6)：821-826.
- 32. Zagouri F， Sergentanis TN， Chrysikos D， et al. Trastuzumab administration during pregnancy：a systematic review and meta-analysis[J]. Breast Cancer Res Treat， 2013， 137(2)：349-357.
- 33. Goodyer MJ， Ismail JR， O’Reilly SP， et al. Safety of trastuzumab(Herceptin?) during pregnancy：two case reports[J]. Cases J， 2009， 2：9329.
- 34. Waterston AM， Graham J. Effect of adjuvant trastuzumab on pregnancy[J]. Clin Oncol， 2006， 24(2)：321-322.
- 35. Azim HA， Peccatori FA， Liptrott SJ， et al. Breast cancer and pregnancy：how safe is trastuzumab?[J]. Nat Rev Clin Oncol， 2009， 6(6)：367-370.
- 36. Pentsuk N， van der Laan JW. An interspecies comparison of plac-ental antibody transfer：new insights into developmental toxicity testing of monoclonal antibodies[J]. Birth Defects Res B Dev Reprod Toxicol， 2009， 86(4)：328-344.
- 37. Piccart-Gebhart MJ， Procter M， Leyland-Jones B， et al. Trastuz-umab after adjuvant chemotherapy in HER2-positive breast cancer[J]. N Engl J Med， 2005， 353(16)：1659-1672.
- 38. Abusief ME， Missmer SA， Ginsburg ES， et al. The effects of paclitaxel， dose density， and trastuzumab on treatment-related amenorrhea in premenopausal women with breast cancer[J]. Cancer， 2010， 116(4)：791-798.
- 39. Azim HA Jr， Metzger-Filho O， de Azambuja E， et al. Pregnancy occurring during or following adjuvant trastuzumab in patients enrolled in the HERA trial (BIG 01-01)[J]. Breast Cancer Res Treat， 2012， 133(1)：387-391.
- 40. Kelly H， Graham M， Humes E， et al. Delivery of a healthy baby after first-trimester maternal exposure to lapatinib[J]. Clin Breast Cancer， 2006， 7(4)：339-341.
- 41. Braems G， Denys H， De Wever O， et al. Use of tamoxifen before and during pregnancy[J]. Oncologist， 2011， 16(11)：1547-1551.
- 42. Tiboni GM， Marotta F， Rossi C， et al. Effects of the aromataseinhibitor letrozole on in utero development in rats[J]. Hum Reprod，.
- 43. ， 23(8)：1719-1723.