摘要:目的: 探討益活清下法治療重癥急性胰腺炎(severe acute pancreatitis, SAP)對血清單核趨化蛋白1及對器官功能不全的影響。 方法 : 依據(jù)納入和排除標(biāo)準(zhǔn),選取SAP患者24例,按1︰1隨機分為治療組和對照組,在接受相同西醫(yī)治療的基礎(chǔ)上,治療組使用中藥“益活清下”法治療,對照組同時接受中藥安慰劑治療。測定患者第0、1、3、5、7天血清MCP1的濃度水平,比較各器官功能不全的發(fā)生率與持續(xù)時間。 結(jié)果 :兩組入院時Rason評分、CT評分、急性生理和慢性健康評價指標(biāo)Ⅱ評分無統(tǒng)計學(xué)差異(〖WTBX〗P  gt;005)。對照組第3天MCP1濃度水平明顯高于治療組,差異有統(tǒng)計學(xué)意義(〖WTBX〗P  lt;005),對照組腸、肝功能不全的發(fā)生率高于治療組,持續(xù)時間長于治療組,但無統(tǒng)計學(xué)差異(〖WTBX〗P  gt;005)。 結(jié)論 :益活清下法治療重癥急性胰腺炎,可降低患者血清MCP1的水平。
Abstract: Objective: To investigated the impact of Yihuo Qingxia method on the serum monocyte chemoattractant protein1 of severe acute pancreatitis (SAP)and on the organs disfunction. Methods : Twentyfour SAP patients who admitted to hospital within 72h after onset were randomized into treatment group (n=12) and control group (n=12). The patients in the treatment group were treated by Yihuo Qingxia method, and the control group were administrated with placebo.The level of the serum mcp1 of the patients on the first,3rd,5th,7thday were measured, as well as the incidence and the duration of disfunction of the organs were compared.〖WTHZ〗Results :There were no statistical significance in admission Rason scores, CT scores, Acute physiology and chronic health evaltionⅡscores(APACHEⅡscores)(P gt;005). The level of the serum Monocyte chemoattractant protein1 of the treatment group was lower than that of the placebo group generally(P lt;005).At the 3rd day after onset,the serum mcp1 level of the control group was significantly higher than that of the treament group(P lt;005).The incidence of the control group of the intestin disfunction and hepatic inadequacy was obviously higher than those of the treatment group,and the duration of the former was longer than that of the latter,but with no satistical significance. Conclusion :Yihuo Qingxia method can effectively cut down the level of the serum mcp1 of severe pancreatitis patients.

引用本文： 金濤,夏慶,趙龍,張海燕,程征宇,薛平,楊曉楠. 益活清下法對重癥急性胰腺炎患者血清單核趨化蛋白-1的影響. 華西醫(yī)學(xué), 2009, 24(10): 2565-. doi: 復(fù)制