• 四川省婦幼保健院·四川省婦女兒童醫(yī)院,四川成都 610031;

目的:探討米索前列醇片在初次早早孕(≤42天)人工流產術前應用的可行性、有效性及安全性。方法:將300例初次妊娠,孕周≤6周,擬行人工流產的婦女隨機分為口服米索組100例(A組)、陰道放置米索組100例(B組)、未使用米索對照組(C組)。A組術前2h口服米索前列醇片400 μg,B組術前2h陰道放置米索前列醇片400 μg。觀察并比較術前用藥的兩組不良反應發(fā)生率、宮頸擴張效果、術中出血量、手術時間及術后宮頸粘連發(fā)生情況。結果:B組不良反應發(fā)生率低于A組,差異有統(tǒng)計學意義(P lt;0.01);A、B兩組間術中宮頸擴張效果、術中出血量、手術時間及術后宮頸粘連發(fā)生率差異均無統(tǒng)計學意義(P gt;0.05),但與C組比較差異有統(tǒng)計學意義。結論:米索前列醇片口服和陰道放藥都可作為初次早早孕人工流產術前的給藥方法。更推薦不良反應較小的陰道放藥。

引用本文： 王曉銀,劉敬濤,徐洲. 米索前列醇在早早孕人工流產術前的應用. 華西醫(yī)學, 2009, 24(9): 2405-2407. doi: 復制

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  2. 2. TANG, O S, H O, P C. The use of misoprostol for early pregnancy failure[J].Current opinion in obstetrics & gynecology,2006,18:163.
  3. 3. CREININ M D, HUANG X, WESTHOFF C. Factors related to successful misoprostol treatment for early pregnancy failure[J]. Obstetrics & Gynecology,2006,107(4):1215.
  4. 4. DAVIS A R, ROBILOTTO C M, WESTHOFF C L. Bleeding patterns after vaginal misoprostol for treatment of early pregnancy failure[J].Human reproduction, 2004, 19:216.
  5. 5. VONHERTZEN, H, PIAGGIO, G, HUONG, N T. Efficacy of two intervals and two routes of administration of misoprostol for termination of early pregnancy: a randomised controlled equivalence trial[J].The Lancet, 2007,15:369.
  6. 6. GUIX C, PALACIO M, FIGUERAS F. Efficacy of two regimens of misoprostol for early secondtrimester pregnancy termination[J]. Fetal diagnosis and therapy, 2005,20:617.
  7. 7. FICIOGUL C, TASDEMIR M, T ASDEMIRS. Effect of vaginal misoprostol application for cervical softening in pregnancy interruption before ten weeks of gestation[J]. Acta Obstet Gynecol Scand,1996, 75:54.