• 四川大學(xué)華西醫(yī)院皮膚性病科,四川成都 610041;

嗜酸性粒細(xì)胞增多性蜂窩織炎(eosinophilic cellulitis,EC)又稱Wells綜合征(Wells’s syndrome),為一種復(fù)發(fā)性肉芽腫性皮炎,伴有嗜酸粒細(xì)胞浸潤。該病較少見,主要為成人發(fā)病,也可累及兒童。本文就嗜酸性粒細(xì)胞增多性蜂窩織炎的病因、臨床表現(xiàn)、組織病理改變、診斷和鑒別診斷、治療的研究進(jìn)展進(jìn)行綜述。

引用本文： 閆薇,劉宏杰,郭在培. 嗜酸性粒細(xì)胞增多性蜂窩織炎研究進(jìn)展. 華西醫(yī)學(xué), 2009, 24(7): 1906-1908. doi: 復(fù)制

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1. WINFIELD H, LAIN E, HORN T, et al. Eosinophilic cellulitislike reaction to subcutaneous etanercept injection[J]. Arch Dermatol,2006,142(2):218-220.
2. FEINMESSER M, DAVID M, GAYER S, et al. Congenital Wells syndrome[J]. Pedoatr Dermatol,1997,14(4):312-315.
3. LUDWIG R J, GRUNDMANNKOLLMANN M, HOLTMEIER W, et al. Herpes simplex virus type 2associated eosinophilic cellulitis (Wells’ syndrome)[J]. J Am Acad Dermatol,2003,48(5 Suppl):S60S61.
4. BASSUKAS I D, GAITANIS G, ZIOGA A, et al. Febrile "migrating" eosinophilic cellulitis with hepatosplenomegaly: adult toxocariasis a case report[J]. Cases J,2008,1(1):356.
5. HURNI M A, GERBIG A W, BRAATHEN LR, et al. Toxocariasis and Wells’ syndrome: a causal relationship?[J] Dermatology,1997,195(4):325-328.
6. HIRSCH K, LUDWIG R J, WOLTER M, et al. Eosinophilic cellulitis (Wells’ syndrome) associated with colon carcinoma[J]. J Dtsch Dermatol Ges,2005,3(7):530-531.
7. RENNER R, KAUER F, TREUDLER R, et al. Eosinophilic cellulitis (Wells’ syndrome) in association with angioimmunoblastic lymphadenopathy[J]. Acta Derm Venereol,2007,87(6):525-528.
8. SAKARIA S S, RAVI A, SWERLICK R, et al. Wells’ syndrome associated with ulcerative colitis: a case report and literature review[J]. J Gastroenterol,2007,42(3):250-252.
9. FRENCH L E, SHAPIRO M, JUNKINSHOPKINS J M, et al. Eosinophilic fasciitis and eosinophilic cellulitis in a patient with abnormal circulating clonal T cells: increased production of interleukin 5 and inhibition by interferon α[J]. J Am Acad Dermatol,2003,49(6):1170-1174.
10. YAGI H, TOKURA Y, MATSUSHITA K, et al. Wells’ syndrome: a pathogenic role for circulating CD4+CD7-T cells expressing interleukin5 mRNA[J]. Br J Dermatol,1997,136(6):918-923.
11. PLOTZ S G, ABECK D, BEHRENDT H, et al. Eosinophilic cellulitis (Wells syndrome)[J]. Hautarzt,2000,51(3):182-186.
12. GOTLIB J. Molecular classification and pathogenesis of eosinophilic disorders: 2005 update[J]. Acta Haematol,2005,114:7–25.
13. DAVIS R F, DUSANJH P, MAJID A, et al. Eosinophilic cellulitis as a presenting feature of chronic eosinophilic leukaemia, secondary to a deletion on chromosome creating the FIP1L1PDGFRA fusion gene[J]. Br J Dermatol,2006,155(5):1087-1089.
14. GHISLAIN P D, VAN EECKHOUT P. Eosinophilic cellulitis of papulonodular presentation (Wells’ syndrome)[J]. J Eur Acad Dermatol Venereol,2005,19(2):226-227.
15. GREEN W H, YOSIPOVITCH G, PICHARDO R O. Recurrent, pruritic dermal plaques and bullae. Diagnosis: eosinophilic cellulitis (Wells syndrome)[J]. Arch Dermatol,2007,143(6):791-796.
16. CONSIGNY S, COURVILLE P, YOUNG P, et al. Histological and clinical forms of the eosinophilic cellulitis[J]. Ann Dermatol Venereol,2001,128(3 Pt 1):213-216.
17. CUDOS E S, LAGUNA R D, RODRIGUEZ M F. Eosinophilic cellulitis presenting as cutaneous blistering[J]. Anales De Pediatría,2009,70(3):313-314.
18. 趙辨.臨床皮膚病學(xué)[M].第3版.南京:江蘇科學(xué)技術(shù)出版社,2001:869.
19. STERN J B, SOBEL H J, ROTCHFORD J P. Wells’ syndrome: is there collagen damage in the flame figures?[J] J Cutan Pathol,1984,11(6):501-505.
20. FERRIER M C, JANINMERCIER A, SOUTEYRAND P, et al. Eosinophilic cellulitis (Wells’ syndrome): ultrastructural study of a case with circulating immune complexes[J]. Dermatologica,1988,176(6):299-304.
21. FERRIER M C, JANINMERCIER A, SOUTEYRAND P, et al. Ultrastructural study of a case with circulating immune complexes[J]. Dermatologica,1988,176(6):299-304.
22. 麥基.皮膚病理學(xué)與臨床的聯(lián)系[M].第3版.北京:北京大學(xué)醫(yī)學(xué)出版社,2007:697-700.
23. 顧有守,靳培英.嗜酸性蜂窩織炎[J].國際皮膚性病學(xué)雜志,1987,(3):141-143.
24. 邱夢桃,顧有守.嗜酸性蜂窩織炎臨床分析(附4例報(bào)告)[J].嶺南皮膚性病科雜志,2007,4(3):135137.
25. 楊慶永,廖元興,林挺.嗜酸性蜂窩織炎一例[J].中華皮膚科雜志,2003,36(3):132.
26. 王紅梅,肖尹,陳丹,等.嗜酸性蜂窩織炎1例[J].中國中西醫(yī)結(jié)合皮膚性病學(xué)雜志,2008,7(3):177178.
27. 曾躍平,馬東來,王寶璽.Well’s綜合征1例[J].中國皮膚性病學(xué)雜志,2008,22(6):373-374.
28. LEE M W, NIXON R L. Eosinophilic cellulitis case report: treatment options[J]. Australas J Dermatol,1994,35(2):95-97.
29. ARONI K, AIVALIOTIS M, LIOSSI A, et al. Eosinophilic cellulitis in a child successfully treated with cetirizine[J]. Acta Derm Venereol,1999,79(4):332.
30. HERR H, KOH J K. Eosinophilic cellulitis (Wells’ syndrome) successfully treated with lowdose cyclosporine[J]. J Korean Med Sci,2001,16(5):664-668.
31. UTIKAL J, PEITSCH W K, KEMMLER N, et al. Bullous eosinophilic cellulitis associated with ulcerative colitis: effective treatment with sulfasalazine and glucocorticoids[J]. Br J Dermatol,2007,156(4):764-766.
32. STAMWESTERVELD E B, DAENEN S, VAN DER MEER J B, et al. Eosinophilic cellulitis (Wells’ syndrome): treatment with minocycline[J]. Acta Derm Venereol,1998,78(2):157.
  1. 1. WINFIELD H, LAIN E, HORN T, et al. Eosinophilic cellulitislike reaction to subcutaneous etanercept injection[J]. Arch Dermatol,2006,142(2):218-220.
  2. 2. FEINMESSER M, DAVID M, GAYER S, et al. Congenital Wells syndrome[J]. Pedoatr Dermatol,1997,14(4):312-315.
  3. 3. LUDWIG R J, GRUNDMANNKOLLMANN M, HOLTMEIER W, et al. Herpes simplex virus type 2associated eosinophilic cellulitis (Wells’ syndrome)[J]. J Am Acad Dermatol,2003,48(5 Suppl):S60S61.
  4. 4. BASSUKAS I D, GAITANIS G, ZIOGA A, et al. Febrile "migrating" eosinophilic cellulitis with hepatosplenomegaly: adult toxocariasis a case report[J]. Cases J,2008,1(1):356.
  5. 5. HURNI M A, GERBIG A W, BRAATHEN LR, et al. Toxocariasis and Wells’ syndrome: a causal relationship?[J] Dermatology,1997,195(4):325-328.
  6. 6. HIRSCH K, LUDWIG R J, WOLTER M, et al. Eosinophilic cellulitis (Wells’ syndrome) associated with colon carcinoma[J]. J Dtsch Dermatol Ges,2005,3(7):530-531.
  7. 7. RENNER R, KAUER F, TREUDLER R, et al. Eosinophilic cellulitis (Wells’ syndrome) in association with angioimmunoblastic lymphadenopathy[J]. Acta Derm Venereol,2007,87(6):525-528.
  8. 8. SAKARIA S S, RAVI A, SWERLICK R, et al. Wells’ syndrome associated with ulcerative colitis: a case report and literature review[J]. J Gastroenterol,2007,42(3):250-252.
  9. 9. FRENCH L E, SHAPIRO M, JUNKINSHOPKINS J M, et al. Eosinophilic fasciitis and eosinophilic cellulitis in a patient with abnormal circulating clonal T cells: increased production of interleukin 5 and inhibition by interferon α[J]. J Am Acad Dermatol,2003,49(6):1170-1174.
  10. 10. YAGI H, TOKURA Y, MATSUSHITA K, et al. Wells’ syndrome: a pathogenic role for circulating CD4+CD7-T cells expressing interleukin5 mRNA[J]. Br J Dermatol,1997,136(6):918-923.
  11. 11. PLOTZ S G, ABECK D, BEHRENDT H, et al. Eosinophilic cellulitis (Wells syndrome)[J]. Hautarzt,2000,51(3):182-186.
  12. 12. GOTLIB J. Molecular classification and pathogenesis of eosinophilic disorders: 2005 update[J]. Acta Haematol,2005,114:7–25.
  13. 13. DAVIS R F, DUSANJH P, MAJID A, et al. Eosinophilic cellulitis as a presenting feature of chronic eosinophilic leukaemia, secondary to a deletion on chromosome creating the FIP1L1PDGFRA fusion gene[J]. Br J Dermatol,2006,155(5):1087-1089.
  14. 14. GHISLAIN P D, VAN EECKHOUT P. Eosinophilic cellulitis of papulonodular presentation (Wells’ syndrome)[J]. J Eur Acad Dermatol Venereol,2005,19(2):226-227.
  15. 15. GREEN W H, YOSIPOVITCH G, PICHARDO R O. Recurrent, pruritic dermal plaques and bullae. Diagnosis: eosinophilic cellulitis (Wells syndrome)[J]. Arch Dermatol,2007,143(6):791-796.
  16. 16. CONSIGNY S, COURVILLE P, YOUNG P, et al. Histological and clinical forms of the eosinophilic cellulitis[J]. Ann Dermatol Venereol,2001,128(3 Pt 1):213-216.
  17. 17. CUDOS E S, LAGUNA R D, RODRIGUEZ M F. Eosinophilic cellulitis presenting as cutaneous blistering[J]. Anales De Pediatría,2009,70(3):313-314.
  18. 18. 趙辨.臨床皮膚病學(xué)[M].第3版.南京:江蘇科學(xué)技術(shù)出版社,2001:869.
  19. 19. STERN J B, SOBEL H J, ROTCHFORD J P. Wells’ syndrome: is there collagen damage in the flame figures?[J] J Cutan Pathol,1984,11(6):501-505.
  20. 20. FERRIER M C, JANINMERCIER A, SOUTEYRAND P, et al. Eosinophilic cellulitis (Wells’ syndrome): ultrastructural study of a case with circulating immune complexes[J]. Dermatologica,1988,176(6):299-304.
  21. 21. FERRIER M C, JANINMERCIER A, SOUTEYRAND P, et al. Ultrastructural study of a case with circulating immune complexes[J]. Dermatologica,1988,176(6):299-304.
  22. 22. 麥基.皮膚病理學(xué)與臨床的聯(lián)系[M].第3版.北京:北京大學(xué)醫(yī)學(xué)出版社,2007:697-700.
  23. 23. 顧有守,靳培英.嗜酸性蜂窩織炎[J].國際皮膚性病學(xué)雜志,1987,(3):141-143.
  24. 24. 邱夢桃,顧有守.嗜酸性蜂窩織炎臨床分析(附4例報(bào)告)[J].嶺南皮膚性病科雜志,2007,4(3):135137.
  25. 25. 楊慶永,廖元興,林挺.嗜酸性蜂窩織炎一例[J].中華皮膚科雜志,2003,36(3):132.
  26. 26. 王紅梅,肖尹,陳丹,等.嗜酸性蜂窩織炎1例[J].中國中西醫(yī)結(jié)合皮膚性病學(xué)雜志,2008,7(3):177178.
  27. 27. 曾躍平,馬東來,王寶璽.Well’s綜合征1例[J].中國皮膚性病學(xué)雜志,2008,22(6):373-374.
  28. 28. LEE M W, NIXON R L. Eosinophilic cellulitis case report: treatment options[J]. Australas J Dermatol,1994,35(2):95-97.
  29. 29. ARONI K, AIVALIOTIS M, LIOSSI A, et al. Eosinophilic cellulitis in a child successfully treated with cetirizine[J]. Acta Derm Venereol,1999,79(4):332.
  30. 30. HERR H, KOH J K. Eosinophilic cellulitis (Wells’ syndrome) successfully treated with lowdose cyclosporine[J]. J Korean Med Sci,2001,16(5):664-668.
  31. 31. UTIKAL J, PEITSCH W K, KEMMLER N, et al. Bullous eosinophilic cellulitis associated with ulcerative colitis: effective treatment with sulfasalazine and glucocorticoids[J]. Br J Dermatol,2007,156(4):764-766.
  32. 32. STAMWESTERVELD E B, DAENEN S, VAN DER MEER J B, et al. Eosinophilic cellulitis (Wells’ syndrome): treatment with minocycline[J]. Acta Derm Venereol,1998,78(2):157.