• 廣州市中醫(yī)醫(yī)院心血管內(nèi)科,廣東廣州 10130;

目的:觀察氨氯地平片治療非杓型老年高血壓患者對血壓晝夜節(jié)律異常及對動態(tài)動脈硬化指數(shù)(AASI)的影響。方法:80例患者每日晨8時頓服氨氯地平5～10mg/d,服藥前及治療8周后行24h動態(tài)血壓監(jiān)測。結(jié)果:80例完成治療的患者中,60例血壓晝夜節(jié)律異常逆轉(zhuǎn),同時改善AASI。而20例血壓晝夜節(jié)律無逆轉(zhuǎn),AASI與治療前比較無差異。結(jié)論:經(jīng)氨氯地平片治療后,75%的非杓型高血壓患者,可改善血壓晝夜節(jié)律異常及AASI。

引用本文： 何皓颋. 氨氯地平對老年高血壓患者血壓晝夜節(jié)律和動態(tài)動脈硬化指數(shù)異常的逆轉(zhuǎn)作用. 華西醫(yī)學(xué), 2009, 24(7): 1844-1846. doi: 復(fù)制

1. MAURIZIO G, ANTONIO P, ALFONSO A, et al . Impact of ambulatory blood pressure on left ventricular diastolic dysfuncfion in uncomplicated arterial systemic hypertension[J]. Am J Cardio,1996,77 (8):597-99..
2. LI Y, DOLAN E, WANG J G, et al . Ambulatory arterial stiffness index:determinant s and outcome[J]. Blood Press Monit,2006,11(2):107-10..
3. LI Y, WANG J G, DOLAN E, et al. Ambulatory arterial stiffness index derived from 24hour ambulatory blood pressure monitoring[J]. Hypertension, 2006,47(5): 359-64..
4. LEONCINI G, RATTO E, VIAZZI F,et al.Increased ambulatory arterial stiffness index is associated with target organ damage in primary hypertension[J].Hypertension,2006,48(3):397-03..
5. 韓全樂,高競生,郝冰.動態(tài)血壓監(jiān)測及其臨床應(yīng)用新進展[J].中國煤炭工業(yè)醫(yī)學(xué)雜志,2008,11(1):125127..
6. O’BRIEN,SHERIDAN J, O’MALLET K. Dipper and non dipper [J ]. The Lancet,1988,11(8):397..
7. 龔蘭生,劉力生. 血壓晝夜變異及其臨床意義[J]. 中華心血管病雜志,1994,22(5):323-25..
8. 劉寶林,孟超,方寧遠．老年高血壓患者血壓晝夜節(jié)律與左心室肥厚的相關(guān)性[J]．上海交通大學(xué)學(xué)報(醫(yī)學(xué)版),2008,28(5):509-11..
9. 劉衛(wèi),劉建國,蘇定馮. 評價抗高血壓藥的新觀點和新方法[J].中國藥學(xué)雜志,1999,15(3):147..
10. YAN L I, JIGUANG WANG, EAMON D, et al. Ambulatory Arterial Stiffness Index Derived from 24Hour Ambulatory Blood Pressure Monitoring[J].Hypertension, 2006, 47(3):359-64..
11. MACWILLIAM J A, MELVIN G S. Systolic and Diastolic Blood Pressure Estimation, with Special Reference to the Auditory Methods [J].BMJ, 1914, 2: 693-97..
12. DOLAN E, THIJS L, LI Y, et al. Ambulatory aterial stiffness index as a predictor of cardiovascular mortality in the Dublin outcome study[J]. Hypertension,2006,47(2):365-70..
13. 張雪娟,徐傳金,唐曉燕,等.動態(tài)血壓監(jiān)測評價苯磺酸氨氯地平和氯沙坦對老年單純收縮期高血壓的降壓療效[J].中國醫(yī)院藥學(xué)雜志,2008,28(3):137-39..
14. 李明珠,杜萱.動態(tài)動脈硬化指數(shù)與動脈硬化研究進展[J].中華老年心腦血管病雜志,2008,17(10):952-54..
  1. 1. MAURIZIO G, ANTONIO P, ALFONSO A, et al . Impact of ambulatory blood pressure on left ventricular diastolic dysfuncfion in uncomplicated arterial systemic hypertension[J]. Am J Cardio,1996,77 (8):597-99..
  2. 2. LI Y, DOLAN E, WANG J G, et al . Ambulatory arterial stiffness index:determinant s and outcome[J]. Blood Press Monit,2006,11(2):107-10..
  3. 3. LI Y, WANG J G, DOLAN E, et al. Ambulatory arterial stiffness index derived from 24hour ambulatory blood pressure monitoring[J]. Hypertension, 2006,47(5): 359-64..
  4. 4. LEONCINI G, RATTO E, VIAZZI F,et al.Increased ambulatory arterial stiffness index is associated with target organ damage in primary hypertension[J].Hypertension,2006,48(3):397-03..
  5. 5. 韓全樂,高競生,郝冰.動態(tài)血壓監(jiān)測及其臨床應(yīng)用新進展[J].中國煤炭工業(yè)醫(yī)學(xué)雜志,2008,11(1):125127..
  6. 6. O’BRIEN,SHERIDAN J, O’MALLET K. Dipper and non dipper [J ]. The Lancet,1988,11(8):397..
  7. 7. 龔蘭生,劉力生. 血壓晝夜變異及其臨床意義[J]. 中華心血管病雜志,1994,22(5):323-25..
  8. 8. 劉寶林,孟超,方寧遠．老年高血壓患者血壓晝夜節(jié)律與左心室肥厚的相關(guān)性[J]．上海交通大學(xué)學(xué)報(醫(yī)學(xué)版),2008,28(5):509-11..
  9. 9. 劉衛(wèi),劉建國,蘇定馮. 評價抗高血壓藥的新觀點和新方法[J].中國藥學(xué)雜志,1999,15(3):147..
  10. 10. YAN L I, JIGUANG WANG, EAMON D, et al. Ambulatory Arterial Stiffness Index Derived from 24Hour Ambulatory Blood Pressure Monitoring[J].Hypertension, 2006, 47(3):359-64..
  11. 11. MACWILLIAM J A, MELVIN G S. Systolic and Diastolic Blood Pressure Estimation, with Special Reference to the Auditory Methods [J].BMJ, 1914, 2: 693-97..
  12. 12. DOLAN E, THIJS L, LI Y, et al. Ambulatory aterial stiffness index as a predictor of cardiovascular mortality in the Dublin outcome study[J]. Hypertension,2006,47(2):365-70..
  13. 13. 張雪娟,徐傳金,唐曉燕,等.動態(tài)血壓監(jiān)測評價苯磺酸氨氯地平和氯沙坦對老年單純收縮期高血壓的降壓療效[J].中國醫(yī)院藥學(xué)雜志,2008,28(3):137-39..
  14. 14. 李明珠,杜萱.動態(tài)動脈硬化指數(shù)與動脈硬化研究進展[J].中華老年心腦血管病雜志,2008,17(10):952-54..