• 四川大學(xué)1華西第四醫(yī)院眼科;2華西醫(yī)院眼科,四川成都610041;

角膜新生血管(corneal neovascularization,CNV)多見于感染、炎癥、外傷或角膜手術(shù)后。血管化的角膜不但嚴(yán)重影響視力,也是角膜移植失敗的主要原因。近年來,由于免疫學(xué)、分子生物學(xué)和藥理學(xué)等學(xué)科的進(jìn)展,對(duì)CNV進(jìn)行了深入的研究,在血管的形成機(jī)制和治療方面取得了一些成果。本文就CNV的治療進(jìn)展作一綜述

引用本文： 李宇,鄧應(yīng)平. 角膜新生血管的治療研究進(jìn)展. 華西醫(yī)學(xué), 2009, 24(5): 1305-1307. doi: 復(fù)制

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1. HAYASHI A, POPOVICH K S, KIM H C, et al. Role of protein tyrosine phosphorylation in rat corneal neovascularization[J]. Graefes Arch Clin Exp Ophthalmol,1997,235(7):460-467.
2. 周蘭新,李立,鄢秀菊.奧曲肽抑制角膜新生血管形成的實(shí)驗(yàn)研究[J].眼科新進(jìn)展,2006,26(9):674-677.
3. 周麗娟,陸曉和,袁偉.螺內(nèi)酯對(duì)大鼠角膜新生血管的影響[J].眼科新進(jìn)展,2009,29(3):170-172.
4. SMITH B T, DHALLA M S, SHAH G K. Intravitreal injection of bevacizumab combined with bertepofin photodynamic therapy for choroidal neovascularization in agerelated macular degeneration [J]. Retina,2008,28:675-681 .
5. WEIGERT G, MICHELS S, SACU S, et al. Intravitreal bevacizumab (Avastin) therapy versus photodynamic therapy plus intravitreal triamcinolone for neovascular agerelated macular degeneration: 6month results of a prospective, randomized, controlled clinical study [J]. Br J Ophthalmol,2008,92:356-360.
6. BARROS L F, BELFORT R JR. The effects of the subconjunctival injection of bevacizumab (Avastin) on angiogenesis in the rat cornea [J]. An Acad Bras Cienc,2007,79(3):389-394.
7. BERDUGO M, ANDRIEUSOLER C, DOAT M, et al. Downregulation of IRS1 expression causes inhibition of corneal angiogenesis [J]. Invest Ophthalmol Vis Sci,2005,46(11):40724078.
8. SINGH N, AMIN S, RICHTER E, et al. Flt1 intraceptors inhibit hypoxiainduced VEGF expression in vitro and corneal neovascularization in vivo [J]. Invest Ophthalmol Vis Sci,2005,46(5):1647-1652.
9. 馮怡,馮玉梅,朱旭東,等.重組人內(nèi)皮抑素滴眼液抑制小鼠角膜新生血管形成的研究[J].眼科研究,2005,23(1):12-15.
10. SHIN S H, KIM J C, CHANG S I, et al. Recombinant kringle 13 of plasminogen inhibits rabbit corneal angiogenesis induced by angiogenin [J]. Cornea,2000,19(2):212-217.
11. MA D H, CHEN J K, KIM W S, et al. Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in inflammationinduced corneal neovascularization [J]. Ophthalmic Res,2001,33(6):353-362 .
12. 唐維強(qiáng),柳林,劉智勇,等.卡托普利對(duì)大鼠角膜新生血管生長(zhǎng)的影響[J].眼科研究,2005,23(1):16-18.
13. BISWAS P S, BANERJEE K, KIM B, et al. Role of inflammatory cytokineinduced cyclooxygenase 2 in the ocular immunopathologic disease herpetic stromal keratitis [J]. Virol,2005,79(16):10589-10600.
14. SUZUKI T, SANO Y, KINOSHITA S. Effects of 1α, 25Dihydroxyvitamin D3 on Langerhans cell migration and corneal neovascularization in mice [J]. Invest Ophthalmol Vis Sci,2000,41(1):154-158.
15. MURATA M, SHIMIZU S, HORIUCHI S, et al. Inhibitory effect of triamcinolone acetonide on corneal neovascularization [J]. Graefes Arch Clin Exp Ophthalmol,2005,26:1-5.
16. KWON Y S, KIM J C. Inhibition of corneal neovascularization by rapamycin [J]. Exp Mol Med,2006,38(2):173-179.
17. SINGH N, HIGGINS E, AMIN S, et al. Unique homologous siRNA blocks hypoxiainduced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization [J]. Cornea,2007,26(1):65-72.
18. EDELMAN J L, CASTRO M R, WEN Y. Correlation of VEGF expression by leukocyte with the growth and regression of blood vessels in the rat cornea [J]. Invest Ophthalmol Vis Sci,1999,40:1112-1122.
19. 黃映湘.光動(dòng)力學(xué)治療角膜新生血管[J].眼科研究,2002,20(3):276-278.
20. 謝立信,史偉云,劉艷霞,等.羊膜移植治療早期重癥眼部燒傷[J].眼外傷職業(yè)眼病雜志,2000,22:483-485.
  1. 1. HAYASHI A, POPOVICH K S, KIM H C, et al. Role of protein tyrosine phosphorylation in rat corneal neovascularization[J]. Graefes Arch Clin Exp Ophthalmol,1997,235(7):460-467.
  2. 2. 周蘭新,李立,鄢秀菊.奧曲肽抑制角膜新生血管形成的實(shí)驗(yàn)研究[J].眼科新進(jìn)展,2006,26(9):674-677.
  3. 3. 周麗娟,陸曉和,袁偉.螺內(nèi)酯對(duì)大鼠角膜新生血管的影響[J].眼科新進(jìn)展,2009,29(3):170-172.
  4. 4. SMITH B T, DHALLA M S, SHAH G K. Intravitreal injection of bevacizumab combined with bertepofin photodynamic therapy for choroidal neovascularization in agerelated macular degeneration [J]. Retina,2008,28:675-681 .
  5. 5. WEIGERT G, MICHELS S, SACU S, et al. Intravitreal bevacizumab (Avastin) therapy versus photodynamic therapy plus intravitreal triamcinolone for neovascular agerelated macular degeneration: 6month results of a prospective, randomized, controlled clinical study [J]. Br J Ophthalmol,2008,92:356-360.
  6. 6. BARROS L F, BELFORT R JR. The effects of the subconjunctival injection of bevacizumab (Avastin) on angiogenesis in the rat cornea [J]. An Acad Bras Cienc,2007,79(3):389-394.
  7. 7. BERDUGO M, ANDRIEUSOLER C, DOAT M, et al. Downregulation of IRS1 expression causes inhibition of corneal angiogenesis [J]. Invest Ophthalmol Vis Sci,2005,46(11):40724078.
  8. 8. SINGH N, AMIN S, RICHTER E, et al. Flt1 intraceptors inhibit hypoxiainduced VEGF expression in vitro and corneal neovascularization in vivo [J]. Invest Ophthalmol Vis Sci,2005,46(5):1647-1652.
  9. 9. 馮怡,馮玉梅,朱旭東,等.重組人內(nèi)皮抑素滴眼液抑制小鼠角膜新生血管形成的研究[J].眼科研究,2005,23(1):12-15.
  10. 10. SHIN S H, KIM J C, CHANG S I, et al. Recombinant kringle 13 of plasminogen inhibits rabbit corneal angiogenesis induced by angiogenin [J]. Cornea,2000,19(2):212-217.
  11. 11. MA D H, CHEN J K, KIM W S, et al. Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in inflammationinduced corneal neovascularization [J]. Ophthalmic Res,2001,33(6):353-362 .
  12. 12. 唐維強(qiáng),柳林,劉智勇,等.卡托普利對(duì)大鼠角膜新生血管生長(zhǎng)的影響[J].眼科研究,2005,23(1):16-18.
  13. 13. BISWAS P S, BANERJEE K, KIM B, et al. Role of inflammatory cytokineinduced cyclooxygenase 2 in the ocular immunopathologic disease herpetic stromal keratitis [J]. Virol,2005,79(16):10589-10600.
  14. 14. SUZUKI T, SANO Y, KINOSHITA S. Effects of 1α, 25Dihydroxyvitamin D3 on Langerhans cell migration and corneal neovascularization in mice [J]. Invest Ophthalmol Vis Sci,2000,41(1):154-158.
  15. 15. MURATA M, SHIMIZU S, HORIUCHI S, et al. Inhibitory effect of triamcinolone acetonide on corneal neovascularization [J]. Graefes Arch Clin Exp Ophthalmol,2005,26:1-5.
  16. 16. KWON Y S, KIM J C. Inhibition of corneal neovascularization by rapamycin [J]. Exp Mol Med,2006,38(2):173-179.
  17. 17. SINGH N, HIGGINS E, AMIN S, et al. Unique homologous siRNA blocks hypoxiainduced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization [J]. Cornea,2007,26(1):65-72.
  18. 18. EDELMAN J L, CASTRO M R, WEN Y. Correlation of VEGF expression by leukocyte with the growth and regression of blood vessels in the rat cornea [J]. Invest Ophthalmol Vis Sci,1999,40:1112-1122.
  19. 19. 黃映湘.光動(dòng)力學(xué)治療角膜新生血管[J].眼科研究,2002,20(3):276-278.
  20. 20. 謝立信,史偉云,劉艷霞,等.羊膜移植治療早期重癥眼部燒傷[J].眼外傷職業(yè)眼病雜志,2000,22:483-485.