• 四川大學(xué)華西醫(yī)院老年科,四川成都 610041;

目的:研究大豆異黃酮對(duì)D半乳糖致衰老大鼠抗氧化能力的影響。方法:用D半乳糖注射Wistar雄性大鼠5個(gè)月,建立衰老模型。對(duì)致衰老模型組、大豆異黃酮組肝臟、心臟和前列腺丙二醛(MDA)含量、超氧化物歧化酶(SOD)、谷胱甘肽過氧化酶(GSHPx)活性進(jìn)行測(cè)定及比較。結(jié)果:低、中、高不同劑量大豆異黃酮灌喂組與模型組大鼠相比,各臟器MDA含量(μmol/L)(心臟:695±093,562±112,435±112比802±111;肝臟:815±085,647±120,515±112比935±135;前列腺:715±092,558±115,423±125比833±124)均有降低,差異有統(tǒng)計(jì)學(xué)意義(P lt;005),而SOD酶活性(nmol/L)(心臟:4732±308,5518±428,6120±368比3225±370;肝臟:18121±506,19015±706,19720±570比17213±512;前列腺:4156±301,4607±421,5015±335比3374±305)和GSHPx酶活性(nmol/L)(心臟:905±096,1111±245,1313±146比713±151;肝臟:902±105,1150±223,1362±192比698±160;前列腺:435±085,613±102,747±155比312±106)有升高,差異同樣具有統(tǒng)計(jì)學(xué)意義(P lt;005);大豆異黃酮攝入量越高,MDA含量越低,而SOD、GSHPx酶活性越高。結(jié)論:攝入適量大豆異黃酮可有效增強(qiáng)大鼠機(jī)體抗氧化能力,從而延緩D半乳糖誘發(fā)的大鼠衰老。

引用本文： 張艷玲,楊中華,董碧蓉. 大豆異黃酮對(duì)衰老大鼠抗氧化功能的影響. 華西醫(yī)學(xué), 2009, 24(5): 1183-1185. doi: 復(fù)制

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  6. 6. 惠伯棣.類胡蘿卜素化學(xué)及生物化學(xué)[M].北京:中國(guó)輕工業(yè)出版社,2005:312327.
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  8. 8. DE ZWART L L, MEERMAN J H N, COMMANDEUR J N M, et al. Biomarkers of free radical damage: applications in experimental animals and in humans[J]. Free Radic Biol Med,1999,26(12):202226.
  9. 9. MILLER E, MALINOWSK K, GATECKA E, et al. Role of flavonoids as antioxidants in human organism[J]. Pol Merkur Lekarski,2008,24(144):556560.
  10. 10. WEI H C, CAI Q Y, RAHN R O. Inhibition of UV light and Fenton reactioninduced oxidative DNA damage by the soybean isoflavone genistein[J]. Carcinogenesis,1996,17(1): 7377.
  11. 11. WOOD C E, CLINE J M, ANTHONY M S, et al. Adrenocortical effects of oral estrogens and soy isoflavones in female monkeys[J]. J Clin Endocrinol Metab,2004,89(5):23192325.
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