目的:探討孟魯司特鈉(順爾寧)對呼吸道合胞病毒(RSV)毛細支氣管炎患兒血清中半胱氨酰白三烯(CysLTs)的影響。方法:將60例4～18個月的RSV毛細支氣管炎患兒隨機分為順爾寧治療組(30例)和常規(guī)治療組(30例),常規(guī)治療組僅給予綜合治療,而順爾寧治療組在綜合治療的基礎(chǔ)上加用孟魯司特口服,用法為4mg每晚1次口服。于治療前和治療后檢測血清中CysLTs水平。結(jié)果:治療前,RSV毛細支氣管炎兩組CysLTs水平均明顯高于正常組(P lt;005),同時CysLTs水平較常規(guī)治療組顯著下降(P lt;005),常規(guī)治療組患兒血清CysLTs水平仍高于正常組(P lt;005)。結(jié)論:順爾寧可降低RSV毛細支氣管炎患兒血清中CysLTs水平,在RSV毛細支氣管炎的抗炎機制中起重要作用,推測RSV毛細支氣管炎患兒口服孟魯司特有可能達到早期干預(yù),從另一條途徑減少哮喘的發(fā)病。
引用本文： 李蘭,樊紅,胡怡萍,王智斌,蔣虹,陽倩,李敏,陳昌輝. 孟魯司特治療毛細支氣管炎前后患兒血清半胱氨酰白三烯的測定. 華西醫(yī)學(xué), 2009, 24(5): 1152-1153. doi: 復(fù)制
版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《華西醫(yī)學(xué)》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編
| 1. | OH J W, SHIN S A, LEE H B. Urine leukotriene E4 and eosinophil cationic protein in nasopharyngeal aspiration from young wheezy children [J]. Pediatr Allergy Immunol,2005,16(5):416421. |
| 2. | WELLIVER R C. Therapy for bronchiolitis:Help wanted [J]. J Pediatr,1997,130(2):170. |
| 3. | PIEDIMONTE G, SIMOES E A. Respiratory syncytial virus and subsequent asthma[J]. Eur Respir J,2002,20(3):515517. |
| 4. | NGAMPHAIBOON J. Montelukast in general pedi atric practices [J]. J Med Assoc Thai,2005,88(4):348. |
| 5. | BONVILLE C A, ROSENBERG H F, DOMACHOWSKE J B. Ribavirin and cysteinylleukotriene 1 receptor blockade as treatment for severe bronchiolitis[J]. Antiviral Res,2006,69(2):53. |
- 1. OH J W, SHIN S A, LEE H B. Urine leukotriene E4 and eosinophil cationic protein in nasopharyngeal aspiration from young wheezy children [J]. Pediatr Allergy Immunol,2005,16(5):416421.
- 2. WELLIVER R C. Therapy for bronchiolitis:Help wanted [J]. J Pediatr,1997,130(2):170.
- 3. PIEDIMONTE G, SIMOES E A. Respiratory syncytial virus and subsequent asthma[J]. Eur Respir J,2002,20(3):515517.
- 4. NGAMPHAIBOON J. Montelukast in general pedi atric practices [J]. J Med Assoc Thai,2005,88(4):348.
- 5. BONVILLE C A, ROSENBERG H F, DOMACHOWSKE J B. Ribavirin and cysteinylleukotriene 1 receptor blockade as treatment for severe bronchiolitis[J]. Antiviral Res,2006,69(2):53.