• 成都軍區(qū)總醫(yī)院感染科,四川成都 610083;

目的:觀察莫西沙星治療肝硬化并發(fā)原發(fā)性腹膜炎的療效。方法:98例病例隨機(jī)分成治療組(51例)和對(duì)照組(47例),治療組使用莫西沙星注射液400mg,靜滴,1次 /天;對(duì)照組使用頭孢哌酮/舒巴坦鈉2g+左氧氟沙星注射液0.2g,靜滴,2次/次,療程7~10天。結(jié)果:治療組總有效率為90.2%,明顯高于對(duì)照組72.3%(P lt;0.05),并且能較快緩解患者感染的癥狀和體征,不良反應(yīng)發(fā)生率僅為3.9%。結(jié)論:莫西沙星是治療肝硬化并發(fā)原發(fā)性腹膜炎安全有效的藥物

引用本文： 李小安,陳鮮蘭,胡建,何勝,沈才飛. 莫西沙星治療肝硬化并發(fā)原發(fā)性腹膜炎的療效觀察. 華西醫(yī)學(xué), 2009, 24(3): 641-643. doi: 復(fù)制

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2. FIGUEIREDO FA,COELHO HS,SOARES JA.Spontaneous bacterial peritonitis in hepatic cirrhosis:prevalence,predictive factors and prognosis[J].Rev Assoc Med Bras,1999,45(2):128-136..
3. 張錦前,楊玉英,吳亮,等.肝硬化合并自發(fā)性細(xì)菌性腹膜炎臨床診斷標(biāo)準(zhǔn)及其病原分析[J].中國(guó)醫(yī)師進(jìn)修雜志,2006,29(4):47-49..
4. 胡傳芳.湖北地區(qū)腹水病人中常見(jiàn)細(xì)菌的分布及耐藥性分析[J].湖北中醫(yī)學(xué)院學(xué)報(bào),2007,9(2):55-56..
5. 朱欣榮,潘云影.頭孢噻肟鈉聯(lián)合左氧氟沙星治療肝硬化并自發(fā)細(xì)菌性腹膜炎療效觀察[J].現(xiàn)代醫(yī)藥衛(wèi)生,2008,24(17):2579-2580..
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7. TORRES A,MUIR JF,CORRIS P,et al.Effectiveness of oral moxi?oxacin in standard ?rstline therapy in communityacquired pneumonia[J].Eur Respir J,2003,21(1):135-143..
8. WILSON R,KUBIN R,BALLIN I,et al.Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis[J].Journal of Antimicrobial Chemotherapy,1999,44(4):501-513..
9. STASS H,RINK A.D,DELESEN H,et al.Pharmacokinetics and peritoneal penetration of moxifloxacin in peritonitis[J].Journal of Antimicrobial Chemotherapy,2006,58(3):693-696..
10. 中華醫(yī)學(xué)會(huì)傳染病與寄生蟲(chóng)病學(xué)會(huì)分會(huì)、肝病學(xué)分會(huì).病毒性肝炎防治方案[J].中華傳染病雜志,2001,19(1):56-62..
11. 王守義.肝硬化自發(fā)性細(xì)菌性腹膜炎的診斷和治療[J].臨床肝膽病雜志,2006,22(1):19-21..
12. 任小華,張郁馨,李暉.頭孢三嗪和環(huán)丙沙星治療慢性重型肝炎并發(fā)原發(fā)性腹膜炎療效比較[J].四川醫(yī)學(xué),1999,20(1):24-25..
13. 謝維釗.左氧氟沙星治療肝硬化腹水并發(fā)原發(fā)性腹膜炎的療效觀察[J].廣東醫(yī)學(xué)院學(xué)報(bào),2001,19(5):365-366..
14. 張斌.肝硬化合并自發(fā)性細(xì)菌性腹膜炎發(fā)病機(jī)制研究進(jìn)展[J].國(guó)外醫(yī)學(xué)·生理、病理科學(xué)與臨床分冊(cè),2003,23(1):103-105..
15. Llovet JM,Bartolí R,Planas R,et al.Bacterial translocation in cirrhotic rats.Its role in the development of spontaneous bacterial peritonitis[J].Gut,1994,35(11):1648-1652..
16. 張慧琳,呂曉菊,王其南,等.舒巴坦 頭孢哌酮與頭孢噻肟隨機(jī)對(duì)照多中心臨床研究[J].中國(guó)抗生素雜志,2001,26(4):274--280..
17. 肖永紅,王進(jìn),趙彩云,等.2006-2007年Mohnarin細(xì)菌耐藥監(jiān)測(cè)[J].中華醫(yī)院感染學(xué)雜志,2008,18(8):1051-1056..
18. 龍?chǎng)?陳虹年,周清.頭孢哌酮/舒巴坦治療自發(fā)性細(xì)菌性腹膜炎療效觀察[J].現(xiàn)代醫(yī)藥衛(wèi)生,2006,22(5):664..
19. 李慶興,潘發(fā)憤,王邦松,等.第三代頭孢菌素對(duì)4666株醫(yī)院致病菌的耐藥情況分析[J].中國(guó)微生態(tài)學(xué)雜志,2000,12(2):93-94..
20. 王進(jìn),李家泰,李耘.氟喹諾酮類(lèi)抗菌藥物對(duì)2554株細(xì)菌的抗菌活性分析[J].中國(guó)抗感染化療雜志,2004,4(1):14-17..
21. MALANGONI MA,SONG J,HERRINGTON J,et al.Randomized controlled trial of moxifloxacin compared with piperacillintazobactam and amoxicillinclavulanate for the treatment of complicated intraabdominal infections[J].Ann Surg,2006,244(2):204-211..
22. 章怡彬,劉明亮,郭慧元.新喹諾酮的結(jié)構(gòu)特征及其對(duì)革蘭陽(yáng)性菌的構(gòu)效關(guān)系[J].國(guó)外醫(yī)藥抗生素分冊(cè),2008,29(1):12-19..
  1. 1. 黎敏,李才,鄧興臣.肝硬化腹水合并自發(fā)性腹膜炎的臨床分析和預(yù)后[J].中國(guó)社區(qū)醫(yī)師,2006,8(143):66-67..
  2. 2. FIGUEIREDO FA,COELHO HS,SOARES JA.Spontaneous bacterial peritonitis in hepatic cirrhosis:prevalence,predictive factors and prognosis[J].Rev Assoc Med Bras,1999,45(2):128-136..
  3. 3. 張錦前,楊玉英,吳亮,等.肝硬化合并自發(fā)性細(xì)菌性腹膜炎臨床診斷標(biāo)準(zhǔn)及其病原分析[J].中國(guó)醫(yī)師進(jìn)修雜志,2006,29(4):47-49..
  4. 4. 胡傳芳.湖北地區(qū)腹水病人中常見(jiàn)細(xì)菌的分布及耐藥性分析[J].湖北中醫(yī)學(xué)院學(xué)報(bào),2007,9(2):55-56..
  5. 5. 朱欣榮,潘云影.頭孢噻肟鈉聯(lián)合左氧氟沙星治療肝硬化并自發(fā)細(xì)菌性腹膜炎療效觀察[J].現(xiàn)代醫(yī)藥衛(wèi)生,2008,24(17):2579-2580..
  6. 6. 陸穎,李宏力.莫西沙星注射液治療急性細(xì)菌感染臨床研究[J].中國(guó)現(xiàn)代醫(yī)藥雜志,2008,10(3):58-60..
  7. 7. TORRES A,MUIR JF,CORRIS P,et al.Effectiveness of oral moxi?oxacin in standard ?rstline therapy in communityacquired pneumonia[J].Eur Respir J,2003,21(1):135-143..
  8. 8. WILSON R,KUBIN R,BALLIN I,et al.Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis[J].Journal of Antimicrobial Chemotherapy,1999,44(4):501-513..
  9. 9. STASS H,RINK A.D,DELESEN H,et al.Pharmacokinetics and peritoneal penetration of moxifloxacin in peritonitis[J].Journal of Antimicrobial Chemotherapy,2006,58(3):693-696..
  10. 10. 中華醫(yī)學(xué)會(huì)傳染病與寄生蟲(chóng)病學(xué)會(huì)分會(huì)、肝病學(xué)分會(huì).病毒性肝炎防治方案[J].中華傳染病雜志,2001,19(1):56-62..
  11. 11. 王守義.肝硬化自發(fā)性細(xì)菌性腹膜炎的診斷和治療[J].臨床肝膽病雜志,2006,22(1):19-21..
  12. 12. 任小華,張郁馨,李暉.頭孢三嗪和環(huán)丙沙星治療慢性重型肝炎并發(fā)原發(fā)性腹膜炎療效比較[J].四川醫(yī)學(xué),1999,20(1):24-25..
  13. 13. 謝維釗.左氧氟沙星治療肝硬化腹水并發(fā)原發(fā)性腹膜炎的療效觀察[J].廣東醫(yī)學(xué)院學(xué)報(bào),2001,19(5):365-366..
  14. 14. 張斌.肝硬化合并自發(fā)性細(xì)菌性腹膜炎發(fā)病機(jī)制研究進(jìn)展[J].國(guó)外醫(yī)學(xué)·生理、病理科學(xué)與臨床分冊(cè),2003,23(1):103-105..
  15. 15. Llovet JM,Bartolí R,Planas R,et al.Bacterial translocation in cirrhotic rats.Its role in the development of spontaneous bacterial peritonitis[J].Gut,1994,35(11):1648-1652..
  16. 16. 張慧琳,呂曉菊,王其南,等.舒巴坦 頭孢哌酮與頭孢噻肟隨機(jī)對(duì)照多中心臨床研究[J].中國(guó)抗生素雜志,2001,26(4):274--280..
  17. 17. 肖永紅,王進(jìn),趙彩云,等.2006-2007年Mohnarin細(xì)菌耐藥監(jiān)測(cè)[J].中華醫(yī)院感染學(xué)雜志,2008,18(8):1051-1056..
  18. 18. 龍?chǎng)?陳虹年,周清.頭孢哌酮/舒巴坦治療自發(fā)性細(xì)菌性腹膜炎療效觀察[J].現(xiàn)代醫(yī)藥衛(wèi)生,2006,22(5):664..
  19. 19. 李慶興,潘發(fā)憤,王邦松,等.第三代頭孢菌素對(duì)4666株醫(yī)院致病菌的耐藥情況分析[J].中國(guó)微生態(tài)學(xué)雜志,2000,12(2):93-94..
  20. 20. 王進(jìn),李家泰,李耘.氟喹諾酮類(lèi)抗菌藥物對(duì)2554株細(xì)菌的抗菌活性分析[J].中國(guó)抗感染化療雜志,2004,4(1):14-17..
  21. 21. MALANGONI MA,SONG J,HERRINGTON J,et al.Randomized controlled trial of moxifloxacin compared with piperacillintazobactam and amoxicillinclavulanate for the treatment of complicated intraabdominal infections[J].Ann Surg,2006,244(2):204-211..
  22. 22. 章怡彬,劉明亮,郭慧元.新喹諾酮的結(jié)構(gòu)特征及其對(duì)革蘭陽(yáng)性菌的構(gòu)效關(guān)系[J].國(guó)外醫(yī)藥抗生素分冊(cè),2008,29(1):12-19..