• 1.四川省內(nèi)江市第一人民醫(yī)院神經(jīng)內(nèi)科，四川內(nèi)江 641000;2.四川大學(xué)華西醫(yī)院神經(jīng)內(nèi)科，四川成都 610041;

目的：探討單純腦白質(zhì)疏松癥(LA)以及LA合并腦梗死及其MRI影像學(xué)嚴(yán)重程度與年齡、性別、高血壓、糖尿病相關(guān)性初步分析。方法：根據(jù)郭氏等2003年制定的LA診斷標(biāo)準(zhǔn)納入168例腦白質(zhì)疏松癥患者，分為A、B兩組：A組95例為單純腦白質(zhì)疏松(LA)，B組73例為L(zhǎng)A合并腦梗死(LA+CI)。兩組患者均行頭MRI檢查。根據(jù)Kinkel等的方法將T2WI顯示腦室周圍高信號(hào)范圍及程度分為5型.結(jié)果：年齡與腦白質(zhì)疏松的嚴(yán)重程度呈線性相關(guān)性(P lt;0.05)，男性與女性間比較腦白質(zhì)疏松的發(fā)生率無(wú)顯著差異(P gt;0.05)，LA以及LA+CI患者，其高血壓及糖尿病伴發(fā)率較高，而且LA+CI組高于LA組(高血壓P lt;0.01，糖尿病P lt;0.01)，LA患者M(jìn)RI表現(xiàn)以1型為主，LA+CI患者表現(xiàn)以2型為主，P lt;0.01)。結(jié)論：腦白質(zhì)疏松癥的嚴(yán)重程度與年齡密切相關(guān)，LA的發(fā)生率在男女性別間無(wú)明顯差異。高血壓、糖尿病可能是LA的危險(xiǎn)因素。LA+CI組與單純LA組相比，其高血壓、糖尿病伴發(fā)率更高且MRI表現(xiàn)程度更重。

引用本文： 周立,周紅雨. 腦白質(zhì)疏松癥病因相關(guān)性初步分析. 華西醫(yī)學(xué), 2009, 24(2): 253-255. doi: 復(fù)制

1.
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3. 郭洪志.腦白質(zhì)疏松癥[J].臨床神經(jīng)病學(xué)雜志，2002，15：3-4..
4. 郭洪志，屈傳強(qiáng).Binswanger病與腦白質(zhì)疏松癥的鑒別與診斷標(biāo)準(zhǔn)[J].腦血管疾病雜志,2003，3：31-35..
5. Kinkel WR，lacobs L，Polachini L，et al，Subcortical arteriosclerotic encephalopathy(Binswanger’s disease)：computed tomographic，nuclear magnenic resonance，and clinical correlations[J].Arch Neurol，1985，42：951-959..
6. Meyer JS,Kawamura J,Terayama Y.White matter lesions in the elderly[J].J Neurol Sci,1992,110(1-2):1-7..
7. Pantoni L, Garcia JH.Pathogenesis of leukoaraiosis[J].Stroke，1997，28:652-659..
8. Wiszniewska M, Devuyst G, Bogousslavsky J,et al.What is the significance of leukoaraiosis in patients with acute ischemic stroke?[J]Arch Neurol，2000，57(7):967973.Comment in:Arch Neurol，2000，57(7):925-926..
9. de Leeuw FE, de Groot JC, Achten E,et al.Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study[J].J Neurol Neurosurg Psychiatry,2001,70(1):914.Comment in:J Neurol Neurosurg Psychiatry,2001,70(1):2-3.
10. de Leeuw FE,de Groot JC,Achten E,et al.Prevalence of cerebral white matter lesions in elderly people:a population based magnetic resonance imaging study.The Rotterdam Scan Study.
11. Ostrow PT, Miller LL.Pathology of small artery disease[J].Adv Neurol,1993,62:93-123..
12. Longstreth WT，Manollo TA，Arnold，et al.Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people[J].Stroke，1999，27(8)：12741282..
13. Baloh RW，Vinters HV.White matter lesions and disequibrium in older people：1 case contol comparison[J].Arch Neurol，1995，52：975-981..
  1. 1.
  2. 2. Hachinski VC，Potter P，Merskey H.Leukoaraiosis[J].Arch Neurol，1987，44(1)：21-23..
  3. 3. 郭洪志.腦白質(zhì)疏松癥[J].臨床神經(jīng)病學(xué)雜志，2002，15：3-4..
  4. 4. 郭洪志，屈傳強(qiáng).Binswanger病與腦白質(zhì)疏松癥的鑒別與診斷標(biāo)準(zhǔn)[J].腦血管疾病雜志,2003，3：31-35..
  5. 5. Kinkel WR，lacobs L，Polachini L，et al，Subcortical arteriosclerotic encephalopathy(Binswanger’s disease)：computed tomographic，nuclear magnenic resonance，and clinical correlations[J].Arch Neurol，1985，42：951-959..
  6. 6. Meyer JS,Kawamura J,Terayama Y.White matter lesions in the elderly[J].J Neurol Sci,1992,110(1-2):1-7..
  7. 7. Pantoni L, Garcia JH.Pathogenesis of leukoaraiosis[J].Stroke，1997，28:652-659..
  8. 8. Wiszniewska M, Devuyst G, Bogousslavsky J,et al.What is the significance of leukoaraiosis in patients with acute ischemic stroke?[J]Arch Neurol，2000，57(7):967973.Comment in:Arch Neurol，2000，57(7):925-926..
  9. 9. de Leeuw FE, de Groot JC, Achten E,et al.Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study[J].J Neurol Neurosurg Psychiatry,2001,70(1):914.Comment in:J Neurol Neurosurg Psychiatry,2001,70(1):2-3.
  10. 10. de Leeuw FE,de Groot JC,Achten E,et al.Prevalence of cerebral white matter lesions in elderly people:a population based magnetic resonance imaging study.The Rotterdam Scan Study.
  11. 11. Ostrow PT, Miller LL.Pathology of small artery disease[J].Adv Neurol,1993,62:93-123..
  12. 12. Longstreth WT，Manollo TA，Arnold，et al.Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people[J].Stroke，1999，27(8)：12741282..
  13. 13. Baloh RW，Vinters HV.White matter lesions and disequibrium in older people：1 case contol comparison[J].Arch Neurol，1995，52：975-981..