• 綿陽(yáng)市中心醫(yī)院耳鼻咽喉科（四川綿陽(yáng)，621000）;

目的 　進(jìn)一步探討更年期咽異感癥的發(fā)病機(jī)制，為正確的診治該疾病提供新的思考。 方法 　試驗(yàn)組納入2011年1月－2012年2月女性更年期咽異感癥患者24例，年齡41～51歲；對(duì)照組納入咽痛為主要表現(xiàn)的急慢性咽炎患者24例，年齡18～44歲。運(yùn)用低濃度丁卡因溶液及氯霉素溶液噴霧咽腔，觀察更年期咽異感癥患者與急慢性咽炎患者用藥后的治療反應(yīng)。 結(jié)果 　更年期咽異感癥患者使用丁卡因后，咽部異物感癥狀普遍加重，而急慢性咽炎患者咽痛癥狀則有減輕，組間構(gòu)成比差異具有統(tǒng)計(jì)學(xué)意義（χ2=25.552，P＜0.05）；氯霉素溶液噴霧后，兩組患者差異無(wú)統(tǒng)計(jì)學(xué)意義（χ2=0.520，P＞0.05）。 結(jié)論 　局部炎癥并非更年期咽異感癥的真實(shí)原因，更年期感覺(jué)神經(jīng)功能的快速退行性變所引起的感覺(jué)不適應(yīng)，即咽部感覺(jué)神經(jīng)功能的下降，可能是咽異感癥的最本質(zhì)原因，針對(duì)神經(jīng)功能退行性變的處理，才是更年期咽異感癥的最佳治療方案。

引用本文： 柳慶君,尹建平,張玲燕,羅剛,鄧偉,胥斌. 女性更年期咽異感癥的病因?qū)W探討. 華西醫(yī)學(xué), 2012, 27(9): 1346-1348. doi: 復(fù)制

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2. 　況光儀, 易慧明, 吳克利, 等. 咽異感癥臨床分型及治療的初步探討 [J]. 中華耳鼻咽喉頭頸外科雜志, 2006, 41(5): 355-358.
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5. 　Dallanezi G, Nahas EA, Freire BF, et al. Quality of life of women with low bone mass in postmenopause[J]. Rev Bras Ginecol Obstet, 2011, 33(3): 133-138.
6. 　Hofer HG. Men in a critical age: Kurt Mendel and the controversy over the male climacterium[J]. Urologe A, 2011, 50(7): 839-845.
7. 　Szkutnik-Fiedler D, Jedrzejczyk M, Grze?kowiak E, et al. The role of phytoestrogen therapy in relieving postmenopausal symptoms[J]. Ginekol Pol, 2010, 81(12): 929-934.
8. 　Agosta C, Atlante M, Benvenuti C. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in menopause[J].Minerva Ginecol, 2011, 63(1): 11-17.
9. 　Nesteruk T, Nesteruk M, Bulik-Pasińska M, et al. Brainstem ischemic stroke without permanent sequelae during the course of spontaneous internal carotid artery dissection-case report[J]. Pol J Radiol, 2012, 77(1): 58-62.
10. 　郭志祥,郭睿.重視咽異感癥的診治[J]. 中華耳鼻咽喉頭頸外科雜志, 2005, 40(8): 638-640.
11. 　Kirk HJ, Pik JH. A novel operative technique to manage a symptomatic synovial cyst associated with an os odontoideum[J]. J Clin Neurosci, 2009, 16(6): 822-824.
12. 　王行煒. 600例難治性咽異感癥患者病因分析 [J]. 臨床耳鼻咽喉頭頸外科雜志, 2006, 20(3): 129-131.
13. 　Wadie GM, Konefal SH, Dias MA, et al. Cervical spondylodiscitis from an ingested pin: a case report[J]. J Pediatr Surg, 2005, 40(3): 593-596.
14. 　葛麗蕎. 以咽異感癥為主要表現(xiàn)的真菌性食管炎23例臨床分析 [J]. 臨床耳鼻咽喉頭頸外科雜志, 2007, 21(15): 712-713.
15. 　Eder F, Meyer F, Huth C, et al. Penetrating abdomino-thoracic injuries: report of four impressive, spectacular and representative cases as well as their challenging surgical management[J]. Pol Przegl Chir, 2011, 83(3): 117-122.
16. 　Boeckxstaens GE, Beaumont H, Mertens V, et al. Effects of lesogaberan on reflux and lower esophageal sphincter function in patients with gastroesophageal reflux disease[J]. Gastroenterology, 2010, 139(2): 409-417.
17. 　Sedinkin AA, Balandin AV, Dimova AD. Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain[J].Ter Arkh, 2005, 77(3): 74-76.
18. 　Wang KC, Chan WS, Tsai CT, et al. Lingual nerve injury following the use of an oropharyngeal airway under endotracheal general anesthesia[J]. Acta Anaesthesiol Taiwan, 2006, 44(2): 119-122.
  1. 1. 　黃選兆, 汪吉寶. 實(shí)用耳鼻咽喉科學(xué)[M]. 北京: 人民衛(wèi)生出版社, 2005: 328-329.
  2. 2. 　況光儀, 易慧明, 吳克利, 等. 咽異感癥臨床分型及治療的初步探討 [J]. 中華耳鼻咽喉頭頸外科雜志, 2006, 41(5): 355-358.
  3. 3. 　Moraes SD, da Fonseca AM, Soares JM Jr, et al. Construction and validation of an instrument that breaks the silence: the impact of domestic and/or sexual violence on women’s health, as shown during climacterium. [J]. Menopause, 2012, 19(1): 16-22.
  4. 4. 　Tchernev G, Cardoso J, Trafeli J, et al. Early syphilitic meningoencephalitis masquerading as postclimacteric endogenous depression--a unique dermatologic presentation[J]. Akush Ginekol, 2011, 50(2): 48-51.
  5. 5. 　Dallanezi G, Nahas EA, Freire BF, et al. Quality of life of women with low bone mass in postmenopause[J]. Rev Bras Ginecol Obstet, 2011, 33(3): 133-138.
  6. 6. 　Hofer HG. Men in a critical age: Kurt Mendel and the controversy over the male climacterium[J]. Urologe A, 2011, 50(7): 839-845.
  7. 7. 　Szkutnik-Fiedler D, Jedrzejczyk M, Grze?kowiak E, et al. The role of phytoestrogen therapy in relieving postmenopausal symptoms[J]. Ginekol Pol, 2010, 81(12): 929-934.
  8. 8. 　Agosta C, Atlante M, Benvenuti C. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in menopause[J].Minerva Ginecol, 2011, 63(1): 11-17.
  9. 9. 　Nesteruk T, Nesteruk M, Bulik-Pasińska M, et al. Brainstem ischemic stroke without permanent sequelae during the course of spontaneous internal carotid artery dissection-case report[J]. Pol J Radiol, 2012, 77(1): 58-62.
  10. 10. 　郭志祥,郭睿.重視咽異感癥的診治[J]. 中華耳鼻咽喉頭頸外科雜志, 2005, 40(8): 638-640.
  11. 11. 　Kirk HJ, Pik JH. A novel operative technique to manage a symptomatic synovial cyst associated with an os odontoideum[J]. J Clin Neurosci, 2009, 16(6): 822-824.
  12. 12. 　王行煒. 600例難治性咽異感癥患者病因分析 [J]. 臨床耳鼻咽喉頭頸外科雜志, 2006, 20(3): 129-131.
  13. 13. 　Wadie GM, Konefal SH, Dias MA, et al. Cervical spondylodiscitis from an ingested pin: a case report[J]. J Pediatr Surg, 2005, 40(3): 593-596.
  14. 14. 　葛麗蕎. 以咽異感癥為主要表現(xiàn)的真菌性食管炎23例臨床分析 [J]. 臨床耳鼻咽喉頭頸外科雜志, 2007, 21(15): 712-713.
  15. 15. 　Eder F, Meyer F, Huth C, et al. Penetrating abdomino-thoracic injuries: report of four impressive, spectacular and representative cases as well as their challenging surgical management[J]. Pol Przegl Chir, 2011, 83(3): 117-122.
  16. 16. 　Boeckxstaens GE, Beaumont H, Mertens V, et al. Effects of lesogaberan on reflux and lower esophageal sphincter function in patients with gastroesophageal reflux disease[J]. Gastroenterology, 2010, 139(2): 409-417.
  17. 17. 　Sedinkin AA, Balandin AV, Dimova AD. Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain[J].Ter Arkh, 2005, 77(3): 74-76.
  18. 18. 　Wang KC, Chan WS, Tsai CT, et al. Lingual nerve injury following the use of an oropharyngeal airway under endotracheal general anesthesia[J]. Acta Anaesthesiol Taiwan, 2006, 44(2): 119-122.