• 1四川大學(xué)華西醫(yī)院麻醉科（成都，610041）;2青島市人民醫(yī)院麻醉科;

目的 　探討在Sprague-Dawley大鼠右心房注射緩激肽對(duì)呼吸的影響。 方法 　7～9 d和21～23 d大鼠在迷走神經(jīng)完整和迷走神經(jīng)切斷的情況下從右心房注射緩激肽，觀察呼吸指標(biāo)的變化。 結(jié)果 ?、?右心房注射緩激肽后，7～9 d大鼠出現(xiàn)呼吸暫停，而在21～23 d大鼠僅出現(xiàn)呼吸抑制（P＜0.05）；② 切斷迷走神經(jīng)后，右心房注射緩激肽在兩組大鼠均不再出現(xiàn)呼吸暫停。 結(jié)論 　右心房注射緩激肽在7～9 d大鼠產(chǎn)生呼吸暫停，且依賴(lài)于迷走神經(jīng)的完整性。

引用本文： 張翔,孫明潔,基鵬,劉斌,王儒蓉. 右心房注射緩激肽對(duì)未成年大鼠呼吸的影響. 華西醫(yī)學(xué), 2012, 27(4): 549-551. doi: 復(fù)制

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  1. 1. 　Dray A, Perkins M. Bradykinin and inflammatory pain[J]. Trends Neurosci, 1993, 16(3): 99-104.
  2. 2. 　Martin RJ, Abu-Shaweesh JM. Control of breathing and neonatal apnea[J]. Biol Neonate, 2005, 87(4): 288-295.
  3. 3. 　Jammes Y, Fornaris E, Mei N, et al. Afferent and efferent components of the bronchial vagal branches in Cats[J]. J Auton Nerv Syst, 1982, 5(2): 165-176.
  4. 4. 　Undem BJ, Carr MJ. Pharmacology of airway afferent nerve activity[J]. Respir Res, 2001, 2(4): 234-244.
  5. 5. 　Soukhova G, Wang Y, Ahmed M, et al. Bradykinin stimulates respiratory drive by activating pulmonary sympathetic afferents in the rabbit[J]. J Appl Physiol, 2003, 95(1): 241-249.
  6. 6. 　Kollarik M, Undem BJ. Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1-/- mice[J]. J Physiol, 2004, 555(pt 1): 115-123.
  7. 7. 　Wang R, Xu F. Postnatal development of right atrial injection of capsaicin-induced apneic response in rats[J]. J Appl Physiol, 2006, 101(1): 60-67.
  8. 8. 　Lee LY, Pisarri TE. Afferent properties and reflex functions of bronchopulmonary C-fibers[J]. Respir Physiol, 2001, 125(1-2): 47-65.
  9. 9. 　Hasan SU, Sarnat HB, Auer RN. Vagal nerve maturation in the fetal lamb: an ultrastructural and morphometric study[J]. Anat Rec, 1993, 237(4): 527-537.
  10. 10. 　Nurmi L, Heikkilä HM, Vapaatalo H, et al. Downregulation of Bradykinin type 2 receptor expression in cardiac endothelial cells during senescence[J]. J Vasc Res, 2012, 49(1): 13-23.
  11. 11. 　Klintschar M, Heimbold C. Association between a functional polymorphism in the MAOA gene and sudden infant death syndrome[J]. Pediatrics, 2012, 129(3): e756-e761.