• 四川大學(xué)華西醫(yī)院腫瘤中心（成都，610041）;

目的 　初步探討影響男性乳腺癌患者預(yù)后的因素。　 方法 　收集2003年1月－2011年12月經(jīng)病理確診、接受治療、臨床資料較完整的36例男性乳腺癌患者的臨床資料。采用對(duì)數(shù)秩檢驗(yàn)和Cox回歸分析影響男性乳腺癌患者預(yù)后的因素。 結(jié)果 　36例患者無(wú)進(jìn)展生存期（PFS）為3～95個(gè)月，中位PFS為45個(gè)月。單因素分析顯示：腫瘤直徑（P=0.001）、陽(yáng)性淋巴結(jié)（P=0.001）、TNM分期（P＜0.001）、手術(shù)方式（P=0.001）是影響預(yù)后的因素。多因素分析顯示：陽(yáng)性淋巴結(jié)（P=0.024）和TNM分期（P=0.022）是影響預(yù)后的主要因素。 結(jié)論 　陽(yáng)性淋巴結(jié)和TNM分期是影響預(yù)后的主要因素，以手術(shù)為主的綜合治療模式是提高男性乳腺癌患者生存率的重要措施。

引用本文： 韓梅,鄭鴻,羅婷,孫愚. 男性乳腺癌預(yù)后的單中心分析. 華西醫(yī)學(xué), 2012, 27(4): 495-500. doi: 復(fù)制

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2. 　Anderson WF, Althuis MD, Brinton LA, et al. Is male breast cancer similar or different than female breast cancer? [J]. Breast Cancer Res Treat, 2004, 83(1): 77-86.
3. 　Giordano SH, Buzdar AU, Hortobagyi GN. Breast cancer in men[J]. Ann Intern Med, 2002, 137(8): 678-687.
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7. 　Contractor KB, Kaur K, Rodrigues GS, et al. Male breast cancer: is the scenario changing[J]. World J Surg Oncol, 2008, 6(58): 58.
8. 　Edge SB, Byrd DR, Compton CC, et al. AJCC cancer staging manual[M]. 7th ed. New York: Springer, 2010: 321-325.
9. 　Speirs V, Shaaban AM. The rising incidence of male breast cancer[J]. Breast Cancer Res Treat, 2009, 115(2): 429-430.
10. 　Yoney A, Kucuk A, Unsal M. Male breast cancer: a retrospective analysis[J]. Cancer Radiother, 2009, 13(2): 103-107.
11. 　Giordano SH. A review of the diagnosis and management of male breast cancer[J]. Oncologist, 2005, 10(7): 471-479.
12. 　Meguerditchian AN, Falardeau M, Martin G. Male breast carcinoma[J]. Can J Surg, 2002, 45(4): 296-302.
13. 　Ben Dhiab T, Bouzid T, Gamoudi A, et al. Male breast cancer: about 123 cases collected at the Institute Salah-Azaiz of Tunis from 1979 to 1999[J]. Bull Cancer, 2005, 92(3): 281-285.
14. 　Comet B, Cutuli B, Penault-Llorca F, et al. Male breast cancer: a review[J]. Bull Cancer, 2009, 96(2): 181-189.
15. 　Gioedano SH, Cohen DS, Buzdar AU, et al. Breast carcinoma in men[J]. Cancer, 2004, 101(1): 51-57.
16. 　Yildirim E, Berbero?lu U. Male breast cancer: a 22-year experience[J]. Eur J Surg Oncol, 1998, 24(6): 548-552.
17. 　Zabel A, Milker-Zabel S, Zuna I, et al. External beam radiotherapy in the treatment of male breast carcinoma: patterns of failure in a single institute experience[J]. Tumori, 2005, 91(2): 151-155.
18. 　Bagley CS, Wesley MN, Young RC, et al. Adjuvant chemotherapy in males with cancer of the breast[J]. J Clin Oncol, 1987, 10(1): 55-60.
19. 　Chakravarthy A, Kim CR. Post-mastectomy radiation in male breast cancer[J]. Radiother Oncol, 2002, 65(2): 99-103.
20. 　Tarone RE, Chu KC. The greater impact of menopause on ER- than ER+ breast cancer incidence: a possible explanation (United States)[J]. Cancer Causes Control, 2002, 13(1): 7-14.
21. 　Iredale R, Brain K, Williams B, et al. The experiences of men with breast cancer in the United Kingdom[J]. Eur J Cancer, 2006, 42(3): 334-341.
  1. 1. 　Cutuli B, Le-Nir CC, Serin D, et al. Evolution of treatment and prognostic factors. Analysis of 489 cases[J]. Crit Rev Oncol Hematol, 2010, 73(3): 246-254.
  2. 2. 　Anderson WF, Althuis MD, Brinton LA, et al. Is male breast cancer similar or different than female breast cancer? [J]. Breast Cancer Res Treat, 2004, 83(1): 77-86.
  3. 3. 　Giordano SH, Buzdar AU, Hortobagyi GN. Breast cancer in men[J]. Ann Intern Med, 2002, 137(8): 678-687.
  4. 4. 　Donegan WL, Redlich PN. Breast cancer in men[J]. Surg Clin North Am, 1996, 76(2): 343-363.
  5. 5. 　Goss PE, Reid C, Pintilie M, et al. Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955-1996[J]. Cancer, 1999, 85(3): 629-639.
  6. 6. 　Malani AK. Male breast cancer: a different disease than female breast cancer[J]. South Med J, 2007, 100(2): 197.
  7. 7. 　Contractor KB, Kaur K, Rodrigues GS, et al. Male breast cancer: is the scenario changing[J]. World J Surg Oncol, 2008, 6(58): 58.
  8. 8. 　Edge SB, Byrd DR, Compton CC, et al. AJCC cancer staging manual[M]. 7th ed. New York: Springer, 2010: 321-325.
  9. 9. 　Speirs V, Shaaban AM. The rising incidence of male breast cancer[J]. Breast Cancer Res Treat, 2009, 115(2): 429-430.
  10. 10. 　Yoney A, Kucuk A, Unsal M. Male breast cancer: a retrospective analysis[J]. Cancer Radiother, 2009, 13(2): 103-107.
  11. 11. 　Giordano SH. A review of the diagnosis and management of male breast cancer[J]. Oncologist, 2005, 10(7): 471-479.
  12. 12. 　Meguerditchian AN, Falardeau M, Martin G. Male breast carcinoma[J]. Can J Surg, 2002, 45(4): 296-302.
  13. 13. 　Ben Dhiab T, Bouzid T, Gamoudi A, et al. Male breast cancer: about 123 cases collected at the Institute Salah-Azaiz of Tunis from 1979 to 1999[J]. Bull Cancer, 2005, 92(3): 281-285.
  14. 14. 　Comet B, Cutuli B, Penault-Llorca F, et al. Male breast cancer: a review[J]. Bull Cancer, 2009, 96(2): 181-189.
  15. 15. 　Gioedano SH, Cohen DS, Buzdar AU, et al. Breast carcinoma in men[J]. Cancer, 2004, 101(1): 51-57.
  16. 16. 　Yildirim E, Berbero?lu U. Male breast cancer: a 22-year experience[J]. Eur J Surg Oncol, 1998, 24(6): 548-552.
  17. 17. 　Zabel A, Milker-Zabel S, Zuna I, et al. External beam radiotherapy in the treatment of male breast carcinoma: patterns of failure in a single institute experience[J]. Tumori, 2005, 91(2): 151-155.
  18. 18. 　Bagley CS, Wesley MN, Young RC, et al. Adjuvant chemotherapy in males with cancer of the breast[J]. J Clin Oncol, 1987, 10(1): 55-60.
  19. 19. 　Chakravarthy A, Kim CR. Post-mastectomy radiation in male breast cancer[J]. Radiother Oncol, 2002, 65(2): 99-103.
  20. 20. 　Tarone RE, Chu KC. The greater impact of menopause on ER- than ER+ breast cancer incidence: a possible explanation (United States)[J]. Cancer Causes Control, 2002, 13(1): 7-14.
  21. 21. 　Iredale R, Brain K, Williams B, et al. The experiences of men with breast cancer in the United Kingdom[J]. Eur J Cancer, 2006, 42(3): 334-341.