劉倩 1 , 丁兀兀 1 , 韓琦 2 , 吳寧 1 , 孟紅 1
  • 德陽市人民醫(yī)院（四川德陽，618000） 1病理科，2超聲科;

目的 　探討乳腺脂肪肉瘤的臨床病理特點及鑒別診斷。 方法 　分析2010年3月收治的1例乳腺多形性脂肪肉瘤的臨床表現(xiàn)、組織病理學特征及免疫表型特點，并復習相關文獻。 結果 　腫瘤由高級別多形性肉瘤和數量不等的多形性脂肪母細胞組成。免疫組織化學：腫瘤細胞呈S-100蛋白陽性表達、CD34灶性陽性表達，細胞角蛋白、上皮膜抗原、巨噬細胞表面抗原、結蛋白、平滑肌肌動蛋白、肌調節(jié)蛋白、肌漿蛋白、CD31均呈陰性表達。結論 　乳腺脂肪肉瘤是一種少見的原發(fā)于乳腺的間葉源性腫瘤，診斷上應首先排除乳腺化生性癌和惡性葉狀腫瘤伴脂肪肉瘤分化，應依據形態(tài)學特點和免疫組織化學結果進行鑒別。

引用本文： 劉倩,丁兀兀,韓琦,吳寧,孟紅. 乳腺多形性脂肪肉瘤一例. 華西醫(yī)學, 2012, 27(10): 1462-1464. doi: 復制

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1. 　Blanchard DK, Reynolds CA, Grant CS, et al. Primary nonphylloides breast sarcomas[J]. Am J Surg, 2003, 186(4): 359-361.
2. 　Adem C, Reynolds C, Ingle JN, et al. Primary breast sarcoma: clinicopathologic series from the mayo clinic and review of the literature[J]. Br J Cancer, 2004, 91(2): 237-241.
3. 　Neumann E. Beitrage zur casuistik der brusdrusengeshwulste[J]. Virchows Arch Path Anat,1862, 24: 316-328.
4. 　Foust RL, Berry AD 3rd, Moinuddin SM. Fine needle aspiration cytology of liposarcoma of the breast: a case report[J]. Acta Cytol, 1994, 38(6): 957-960.
5. 　Carpanelli JB, Lempel G, Gatta C. Report of a Case of liposarcoma of the mammary gland[J]. Sem Med, 1963, 123（25）: 321-322.
6. 　Nandipati KC, Nerkar H, Satterfield J, et al. Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature[J]. Breast J, 16(5): 537-540.
7. 　Pant I, Kaur G, Joshi SC, et al. Myxoid liposarcoma of the breast in a 25-year-old female as a diagnostic pitfall in fine needle aspiration cytology: report of a rare case[J]. Diagn Cytopathol, 2008, 36(9): 674-677.
8. 　常紅波, 曹紅梅, 賈化霞. 男性乳腺脂肪肉瘤1例的超聲表現(xiàn)[J]. 中國超聲醫(yī)學雜志, 2003, 19(11): 851.
9. 　莫爵飛. 男性脂肪肉瘤一例報道[J]. 實用癌癥雜志, 1998, 13(3): 234.
10. 　Padmanabhan V, Dahlstrom JE, Chong GC, et al. Phyllodes tumor with lobular carcinoma in situ and liposarcomatous stroma[J]. Pathology, 1997, 29(2): 224-226.
11. 　Vivian JB, Tan EG, Frayne JR, et al. Bilateral liposarcoma of the breast[J]. Aust N Z J Surg, 1993, 63(8): 658-659.
12. 　Hummer CD, Burkart TJ. Liposarcoma of the breast. A case of bilateral involvement[J]. Am J Surg, 1967, 113(4): 558-561.
13. 　Gallagher KE, Wu HH. Pathologic quiz case: unilateral breast mass in a 75-year-old woman[J]. Arch Pathol Lab Med, 2001, 125(11): 1503-1504.
14. 　Austin RM, Dupree WB. Liposarcoma of the breast: a clinicopathologic study of 20 cases[J]. Hum Pathol, 1986, 17(9): 906-913.
15. 　Pandey M, Mathew A, Abraham EK, et al. Primary sarcoma of the breast[J]. J Surg Oncol, 2004, 87(3): 121-125.
  1. 1. 　Blanchard DK, Reynolds CA, Grant CS, et al. Primary nonphylloides breast sarcomas[J]. Am J Surg, 2003, 186(4): 359-361.
  2. 2. 　Adem C, Reynolds C, Ingle JN, et al. Primary breast sarcoma: clinicopathologic series from the mayo clinic and review of the literature[J]. Br J Cancer, 2004, 91(2): 237-241.
  3. 3. 　Neumann E. Beitrage zur casuistik der brusdrusengeshwulste[J]. Virchows Arch Path Anat,1862, 24: 316-328.
  4. 4. 　Foust RL, Berry AD 3rd, Moinuddin SM. Fine needle aspiration cytology of liposarcoma of the breast: a case report[J]. Acta Cytol, 1994, 38(6): 957-960.
  5. 5. 　Carpanelli JB, Lempel G, Gatta C. Report of a Case of liposarcoma of the mammary gland[J]. Sem Med, 1963, 123（25）: 321-322.
  6. 6. 　Nandipati KC, Nerkar H, Satterfield J, et al. Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature[J]. Breast J, 16(5): 537-540.
  7. 7. 　Pant I, Kaur G, Joshi SC, et al. Myxoid liposarcoma of the breast in a 25-year-old female as a diagnostic pitfall in fine needle aspiration cytology: report of a rare case[J]. Diagn Cytopathol, 2008, 36(9): 674-677.
  8. 8. 　常紅波, 曹紅梅, 賈化霞. 男性乳腺脂肪肉瘤1例的超聲表現(xiàn)[J]. 中國超聲醫(yī)學雜志, 2003, 19(11): 851.
  9. 9. 　莫爵飛. 男性脂肪肉瘤一例報道[J]. 實用癌癥雜志, 1998, 13(3): 234.
  10. 10. 　Padmanabhan V, Dahlstrom JE, Chong GC, et al. Phyllodes tumor with lobular carcinoma in situ and liposarcomatous stroma[J]. Pathology, 1997, 29(2): 224-226.
  11. 11. 　Vivian JB, Tan EG, Frayne JR, et al. Bilateral liposarcoma of the breast[J]. Aust N Z J Surg, 1993, 63(8): 658-659.
  12. 12. 　Hummer CD, Burkart TJ. Liposarcoma of the breast. A case of bilateral involvement[J]. Am J Surg, 1967, 113(4): 558-561.
  13. 13. 　Gallagher KE, Wu HH. Pathologic quiz case: unilateral breast mass in a 75-year-old woman[J]. Arch Pathol Lab Med, 2001, 125(11): 1503-1504.
  14. 14. 　Austin RM, Dupree WB. Liposarcoma of the breast: a clinicopathologic study of 20 cases[J]. Hum Pathol, 1986, 17(9): 906-913.
  15. 15. 　Pandey M, Mathew A, Abraham EK, et al. Primary sarcoma of the breast[J]. J Surg Oncol, 2004, 87(3): 121-125.