狼瘡樣綜合征和抗中性粒細胞胞漿抗體(ANCA)陽性的血管炎合并甲亢在臨床中十分罕見.為了找出這三種疾病之間的關(guān)系,作者借助循證醫(yī)學(xué)的方法,根據(jù)患者病情,提出臨床問題,從PubMed(1966～2003年)、中國生物醫(yī)學(xué)文獻數(shù)據(jù)庫(CBM)(1978～2003年)、荷蘭醫(yī)學(xué)文摘數(shù)據(jù)庫(EMBase)(1974～2003年)查找相關(guān)信息.結(jié)果發(fā)現(xiàn)抗甲狀腺藥物的副反應(yīng)是對該病例的最好解釋,并據(jù)此采取了相應(yīng)治療措施,使患者病情獲得明顯好轉(zhuǎn).
引用本文： 楊立川,肖艱,李孜,蘇白海,冀玲,劉先蓉,樊均明. 抗甲狀腺藥物誘導(dǎo)的狼瘡樣綜合征循證診斷與治療的個案分析. 中國循證醫(yī)學(xué)雜志, 2004, 04(7): 499-502. doi: 復(fù)制
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| 6. | ［5］Kawasaki Y,Suzuki J,Sike T,Isome M,Nozawa R,Suzuki S,Kume K,Suzuki H.A pediatric case of myeloperoxidase-antineutrophil cytoplasmic (ANCA)-related crescentic glomerulonephritis associated with propylthiouracil treatment for Graves’ disease[J].Nippon Jinzo Gakkai Shi,1998; 40(8):612-617. |
- 1. ［1］Mathieu E,Fain O,Sitbon M,Thomas M.Systemic adverse effect of antithyroid drugs[J].Clin Rheumatol,1999; 18(1):66-68.
- 2. ［2］Rodrigue S,Laborde H,Catoggio PM.Systemic lupus erythematosus and thyrotoxicosis:a hitherto little recognised association.Ann[J].Rheum Dis,1989; 48(5):424-427.
- 3. ［3］Xu X,Zhao M,Zhang Y,Guo X,Wang H.Clinicopathological characteristics of propylthiouracil-induced antineutrophil cytoplasmic antibodies-positive vasculitis and their target antigens:a report of 4 cases and literature review[J].Chinese Journal of Internal Medicine,2002; 41(6):404-407.
- 4. 徐旭東,趙明輝,章友康,郭曉惠,王海燕.丙基硫氧嘧啶導(dǎo)致的抗中性粒細胞胞質(zhì)抗體陽性小血管炎及其靶抗原研究[J].中華內(nèi)科學(xué)雜志,2002; 41(6):404～407.
- 5. ［4］Yamada A,Sato K,Hara M,Tochimoto A,Takagi S,Hizuka N,Takano K.Propylthiouracil-induced lupus-like syndrome developing in a Graves’ patient with a sibling with systemic lupus erythematosus[J].Intern Med,2002; 41(12):1 204-1 208.
- 6. ［5］Kawasaki Y,Suzuki J,Sike T,Isome M,Nozawa R,Suzuki S,Kume K,Suzuki H.A pediatric case of myeloperoxidase-antineutrophil cytoplasmic (ANCA)-related crescentic glomerulonephritis associated with propylthiouracil treatment for Graves’ disease[J].Nippon Jinzo Gakkai Shi,1998; 40(8):612-617.