• 四川大學華西醫(yī)院腎臟內(nèi)科（成都 610041）;

目的 　觀察還原型谷胱甘肽對急性腎衰竭的療效和安全性。
方法 　采取拋硬幣法將23例急性腎衰竭患者隨機分為治療組（n=10）和對照組（n=13）。治療組在常規(guī)治療的基礎(chǔ)上給予還原型谷胱甘肽1 200 mg，靜脈滴注，每日1次，療程4周；而對照組只給予常規(guī)治療。于治療前及治療第1、2、3、4周結(jié)束時檢測血肌酐、尿素氮，療程結(jié)束后評估近端、遠端腎小管功能。觀察記錄主要臨床癥狀的改善情況及藥物不良反應(yīng)。
結(jié)果 　治療組惡心、嘔吐改善時間及少尿期持續(xù)時間明顯短于對照組。治療組血肌酐水平下降幅度雖大于對照組，但兩組間比較差異無統(tǒng)計學意義。療程結(jié)束時兩組腎小管功能比較，治療組優(yōu)于對照組。
結(jié)論 　還原型谷胱甘肽用于急性腎衰竭的治療，有助于腎功能的早期恢復(fù)。但由于樣本量較小，今后尚需開展更大樣本，更高質(zhì)量的隨機對照試驗加以驗證。

引用本文： 邱紅渝,唐萬欣,陶冶,米緒華,徐原寧,黃頌敏. 還原型谷胱甘肽治療急性腎功能衰竭的隨機對照試驗. 中國循證醫(yī)學雜志, 2007, 07(2): 104-107. doi: 復(fù)制

1. Liu P. Acute Renal Failure. In: Wang HY. Nephrology. 2nd eds. Beijing: People’s Medical Publishing House, 1998. 1341.
2. Nephrol Dial Transplant, 2006; 21(5): 1240–1247.
3. Chen M, Guo RS, Chen ZY, et al. The protective effect of melatonin in acute ischemia reperfusion renal injury. Chinese Journal Of Nephrology, Dialysis & Transplantation, 1999, 8(1): 27–30.
4. 劉平. 急性腎功能衰竭. 見: 王海燕, 主編. 腎臟病學. 第2版. 北京: 人民衛(wèi)生出版社, 1998. 1341.
5. Nitescu N, Ricksten SE, Marcussen N, et al. N-acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion.
6. Polat A, Parlakpinar H, Tasdemir S, Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Act a Histochem, 2006, 108(5): 365–371.
7. Schumer M, Colombel MC, Sawchuk TS, et al. Morphologic, biochemical and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol, 1992, 140: 831.
8. 陳敏, 郭仁壽, 陳重義, 等. 褪黑素在急性腎缺血再灌注損傷中的防治作用及其對細胞凋亡的影響. 腎臟病與透析腎移植雜志, 1999, 8(1): 27–30.
9. Morel G, Bonnet P, Cossec B, et al. The role of glutathione and cysteine conjugates in the nephrotoxicity of oxylene in rats. Archtoxicol, 1998, 72: 553–558.
  1. 1. Liu P. Acute Renal Failure. In: Wang HY. Nephrology. 2nd eds. Beijing: People’s Medical Publishing House, 1998. 1341.
  2. 2. Nephrol Dial Transplant, 2006; 21(5): 1240–1247.
  3. 3. Chen M, Guo RS, Chen ZY, et al. The protective effect of melatonin in acute ischemia reperfusion renal injury. Chinese Journal Of Nephrology, Dialysis & Transplantation, 1999, 8(1): 27–30.
  4. 4. 劉平. 急性腎功能衰竭. 見: 王海燕, 主編. 腎臟病學. 第2版. 北京: 人民衛(wèi)生出版社, 1998. 1341.
  5. 5. Nitescu N, Ricksten SE, Marcussen N, et al. N-acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion.
  6. 6. Polat A, Parlakpinar H, Tasdemir S, Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Act a Histochem, 2006, 108(5): 365–371.
  7. 7. Schumer M, Colombel MC, Sawchuk TS, et al. Morphologic, biochemical and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol, 1992, 140: 831.
  8. 8. 陳敏, 郭仁壽, 陳重義, 等. 褪黑素在急性腎缺血再灌注損傷中的防治作用及其對細胞凋亡的影響. 腎臟病與透析腎移植雜志, 1999, 8(1): 27–30.
  9. 9. Morel G, Bonnet P, Cossec B, et al. The role of glutathione and cysteine conjugates in the nephrotoxicity of oxylene in rats. Archtoxicol, 1998, 72: 553–558.