• ：1南昌大學(xué)醫(yī)學(xué)院（南昌，330006）;;
  • 2南昌大學(xué)第一附屬醫(yī)院整形美容科;

【摘 要】 目的 總結(jié)自體顆粒脂肪移植技術(shù)在面部的研究與實(shí)踐，探討該技術(shù)在實(shí)際操作中的不同觀點(diǎn)。 方法 查閱近年來國內(nèi)外有關(guān)面部自體顆粒脂肪移植的文獻(xiàn)，進(jìn)行綜合分析。 結(jié)果 自體顆粒脂肪移植技術(shù)已日趨成熟，應(yīng)用在面部不僅能調(diào)整面部輪廓比例、恢復(fù)組織容量，還能改善局部皮膚質(zhì)地，用于面部填充、面部年輕化等治療，可獲得良好臨床效果。目前在供區(qū)選擇、顆粒脂肪采集方法、純化處理技術(shù)等具體操作方面尚存在爭議，但所采取的自體顆粒脂肪移植技術(shù)的基本原則一致。 結(jié)論 從循證醫(yī)學(xué)角度來看，自體顆粒脂肪移植技術(shù)在面部應(yīng)用的臨床經(jīng)驗(yàn)很多，但是客觀證據(jù)不足，有待進(jìn)一步研究。

引用本文： 韓超 ,劉麗忠,廖懷偉,文輝才. 自體顆粒脂肪移植技術(shù)在面部臨床應(yīng)用的進(jìn)展. 中國修復(fù)重建外科雜志, 2012, 26(1): 117-120. doi: 復(fù)制

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1. suggested clinical guidelines based on a review of recent literature. Ann Plast Surg, 2008, 60(1): 98-102.
2. site. Plast Reconstr Surg, 2004, 113(1): 391-397.
3. Organs, 2004, 178(2): 87-92.
4. Dermatol Surg, 2001, 27(9): 819-826.
5. Surg, 2005, 116(6): 1832-1833.
6. cannula on adipocyte survival and the optimum temperature for fat graft storage: an experimental study. J Plast Reconstr Aesthet Surg, 2009, 62(9): 1210-1214.
7. after lipasuctian. Plast Reconstr Surg, 2002, 109(2): 761-767.
8. Facial Plast Surg, 2004, 20(2): 135-143.
9. character affects the in vivo performance of purified adipocyte fat.
10. grafts. Aesthet Surg J, 2008, 28(3): 306-312.
11. site. Plast Reconstr Surg, 2004, 113(1): 391-395.
12. and morphometric study in rabbits. Scand J Plast Reconstr Surg Hand Surg, 1994, 28(4): 241-247.
13. Surg, 2002, 10(7): 1731-1744.
14. Aesthetic Plast Surg, 2003, 27(4): 243-253.
15. Aesthet Surg, 2010, 63(3): 488-492.
16. 李青峰. 自體脂肪移植臨床原則與問題. 中國美容整形外科雜志, 2010, 21(9): 513-514.
17. Marcus BC. The use of autologous fat for facial rejuvenation. Obstet Gynecol Clin North Am, 2010, 37(4): 521-531.
18. Locke MB, de Chalain TM. Current practice in autologous fat transplantation:.
19. Scarborough DA, Schuen W, Bisaccia E. Fat transfer for aging skin: technique for rhytids. J Dermatol Surg Oncol, 1990, 16(7): 651-655.
20. Rohrich RJ, Sorokin ES, Brown SA. In search of improved fat transfer viability: a quantitative analysis of the role of centrifugation and harvest.
21. von Heimburg D, Hemmrich K, Haydarlioglu S, et al. Comparison of viable cell yield from excised versus aspirated adipose tissue. Cells Tissues.
22. Sommer B, Sattler G. Current concepts of fat graft survival: histology of aspirated adipose tissue and review of the literature. Dermatol Surg, 2000, 26(12): 1159-1166.
23. Shiffman MA, Mirrafati S. Fat transfer techniques: the effects of harvest and transfer methods on adipocyte viability and review of the literature.
24. Nguyen A, Pasyk KA, Bouvier TN, et al. Comparative study of survival of adipose tissue taken and transplanted by different techniques. Plast Reconstr Surg, 1990, 85(3): 378-386.
25. Prado A, Castillo P, Gaete F. Does vacuum pressure extraction of fat affect the infranatant cellularity ofliposuction spectmens? Plast Reconstr.
26. Sykes JM, Tapias V, Pu LL. Autologous fat grafting viability: lower third of the face. Facial Plast Surg, 2010, 26(5): 376-384.
27. Erdim M, Tezel E, Numanoglu A, et al. The effects of the size of liposuction.
28. Coleman SR. Structural fat grafts: the ideal filler? Clin Plast Surg, 2001, 28(1): 111-119.
29. Boschert MT, Beckert BW, Puekett CL, et al. Analysis of lipocyte viability.
30. Rubin A, Hoefflin SM. Fat purification: survival of the fittest. Plast Reeoastr Surg, 2002, 109(4): 1463-1464.
31. Tzikan TL. Lipografting: autologous fat grafting for total facial rejuvenation.
32. Piasecki JH, Moreno K, Gutowski KA. Beyond the cells: scaffold matrix.
33. Piasecki JH, Gutowski KA, Lahvis GP, et al. An experimental model for improving fat graft viability and purity. Plast Reconstr Surg, 2007, 119(5): 1571-1583.
34. Rohrich RJ, Sorokin ES, Brown SA. In search of improved fat transfer viability: a quantitative analysis of the role of centrifugation and harvest.
35. Marques A, Brenda E, Saldiva PH, et al. Autologous fat grafts: a quantitative.
36. Coleman SR. Facial recontouring with lipostructure. Clin Plast Surg, 1997, 24(2): 347-367.
37. Roberts TL 3rd, Toledo LS, Badin AZ. Augmentation of the buttocks by micro fat grafting. Aesth Surg J, 2001, 21(4): 311-319.
38. Gonzalez AM, Lobocki C, Kelly CP, et al. An alternative method for harvest and processing fat grafts: an in vitro study of cell viability and survival. Plast Reconstr Surg, 2007, 120(1): 285-294．.
39. Barret JP, Sarobe N, Grande N, et al. Maximizing results of lipofilling in facial reconstruction. Clin Plastic Surg, 2009, 36(3): 487-492.
40. Coleman SR. Structural fat grafting: more than a permanent filler. Plast Reconstr Surg, 2006, 118(3 Suppl): 108S-120S.
41. 趙坤, 梁杰, 彭智. 提高自體顆粒脂肪移植成活率的基礎(chǔ)研究及臨床進(jìn)展. 中國實(shí)用醫(yī)藥, 2010, 5(5): 238-240.
42. 李青峰. 自體脂肪移植技術(shù)的臨床應(yīng)用. 中華整形外科雜志, 2009, 25 (6): 401-402.
43. 謝蕓, 鄭丹寧, 李青峰, 等. 自體脂肪移植綜合技術(shù)在面部輪廓整形中的應(yīng)用. 中華整形外科雜志, 2010, 26(3): 178-181.
44. Coleman SR. Hand rejuvenation with structural fat grafting. Plast Reconstr.
45. Coleman SR. Stuctional fat grafting. Dermatologic Surg, 2005, 31: 1714.
46. 謝蕓, 鄭丹寧, 李青峰. 自體脂肪移植在顳部分層填充治療的應(yīng)用. 中國美容整形外科雜志, 2010, 21(9): 515-517.
47. Trepsat F. Periorbital rejuvenation combining fat grafting and blepharoplasties.
48. 鄭丹寧, 謝蕓, 李青峰. 面部脂肪移植并發(fā)癥的預(yù)防. 中國美容醫(yī)學(xué), 2007, 16(4): 574-576.
49. Ohara H, Kishi K, Nakajima T. The unilocular fat-cell graft. J Plast Reconstr.
  1. 1. suggested clinical guidelines based on a review of recent literature. Ann Plast Surg, 2008, 60(1): 98-102.
  2. 2. site. Plast Reconstr Surg, 2004, 113(1): 391-397.
  3. 3. Organs, 2004, 178(2): 87-92.
  4. 4. Dermatol Surg, 2001, 27(9): 819-826.
  5. 5. Surg, 2005, 116(6): 1832-1833.
  6. 6. cannula on adipocyte survival and the optimum temperature for fat graft storage: an experimental study. J Plast Reconstr Aesthet Surg, 2009, 62(9): 1210-1214.
  7. 7. after lipasuctian. Plast Reconstr Surg, 2002, 109(2): 761-767.
  8. 8. Facial Plast Surg, 2004, 20(2): 135-143.
  9. 9. character affects the in vivo performance of purified adipocyte fat.
  10. 10. grafts. Aesthet Surg J, 2008, 28(3): 306-312.
  11. 11. site. Plast Reconstr Surg, 2004, 113(1): 391-395.
  12. 12. and morphometric study in rabbits. Scand J Plast Reconstr Surg Hand Surg, 1994, 28(4): 241-247.
  13. 13. Surg, 2002, 10(7): 1731-1744.
  14. 14. Aesthetic Plast Surg, 2003, 27(4): 243-253.
  15. 15. Aesthet Surg, 2010, 63(3): 488-492.
  16. 16. 李青峰. 自體脂肪移植臨床原則與問題. 中國美容整形外科雜志, 2010, 21(9): 513-514.
  17. 17. Marcus BC. The use of autologous fat for facial rejuvenation. Obstet Gynecol Clin North Am, 2010, 37(4): 521-531.
  18. 18. Locke MB, de Chalain TM. Current practice in autologous fat transplantation:.
  19. 19. Scarborough DA, Schuen W, Bisaccia E. Fat transfer for aging skin: technique for rhytids. J Dermatol Surg Oncol, 1990, 16(7): 651-655.
  20. 20. Rohrich RJ, Sorokin ES, Brown SA. In search of improved fat transfer viability: a quantitative analysis of the role of centrifugation and harvest.
  21. 21. von Heimburg D, Hemmrich K, Haydarlioglu S, et al. Comparison of viable cell yield from excised versus aspirated adipose tissue. Cells Tissues.
  22. 22. Sommer B, Sattler G. Current concepts of fat graft survival: histology of aspirated adipose tissue and review of the literature. Dermatol Surg, 2000, 26(12): 1159-1166.
  23. 23. Shiffman MA, Mirrafati S. Fat transfer techniques: the effects of harvest and transfer methods on adipocyte viability and review of the literature.
  24. 24. Nguyen A, Pasyk KA, Bouvier TN, et al. Comparative study of survival of adipose tissue taken and transplanted by different techniques. Plast Reconstr Surg, 1990, 85(3): 378-386.
  25. 25. Prado A, Castillo P, Gaete F. Does vacuum pressure extraction of fat affect the infranatant cellularity ofliposuction spectmens? Plast Reconstr.
  26. 26. Sykes JM, Tapias V, Pu LL. Autologous fat grafting viability: lower third of the face. Facial Plast Surg, 2010, 26(5): 376-384.
  27. 27. Erdim M, Tezel E, Numanoglu A, et al. The effects of the size of liposuction.
  28. 28. Coleman SR. Structural fat grafts: the ideal filler? Clin Plast Surg, 2001, 28(1): 111-119.
  29. 29. Boschert MT, Beckert BW, Puekett CL, et al. Analysis of lipocyte viability.
  30. 30. Rubin A, Hoefflin SM. Fat purification: survival of the fittest. Plast Reeoastr Surg, 2002, 109(4): 1463-1464.
  31. 31. Tzikan TL. Lipografting: autologous fat grafting for total facial rejuvenation.
  32. 32. Piasecki JH, Moreno K, Gutowski KA. Beyond the cells: scaffold matrix.
  33. 33. Piasecki JH, Gutowski KA, Lahvis GP, et al. An experimental model for improving fat graft viability and purity. Plast Reconstr Surg, 2007, 119(5): 1571-1583.
  34. 34. Rohrich RJ, Sorokin ES, Brown SA. In search of improved fat transfer viability: a quantitative analysis of the role of centrifugation and harvest.
  35. 35. Marques A, Brenda E, Saldiva PH, et al. Autologous fat grafts: a quantitative.
  36. 36. Coleman SR. Facial recontouring with lipostructure. Clin Plast Surg, 1997, 24(2): 347-367.
  37. 37. Roberts TL 3rd, Toledo LS, Badin AZ. Augmentation of the buttocks by micro fat grafting. Aesth Surg J, 2001, 21(4): 311-319.
  38. 38. Gonzalez AM, Lobocki C, Kelly CP, et al. An alternative method for harvest and processing fat grafts: an in vitro study of cell viability and survival. Plast Reconstr Surg, 2007, 120(1): 285-294．.
  39. 39. Barret JP, Sarobe N, Grande N, et al. Maximizing results of lipofilling in facial reconstruction. Clin Plastic Surg, 2009, 36(3): 487-492.
  40. 40. Coleman SR. Structural fat grafting: more than a permanent filler. Plast Reconstr Surg, 2006, 118(3 Suppl): 108S-120S.
  41. 41. 趙坤, 梁杰, 彭智. 提高自體顆粒脂肪移植成活率的基礎(chǔ)研究及臨床進(jìn)展. 中國實(shí)用醫(yī)藥, 2010, 5(5): 238-240.
  42. 42. 李青峰. 自體脂肪移植技術(shù)的臨床應(yīng)用. 中華整形外科雜志, 2009, 25 (6): 401-402.
  43. 43. 謝蕓, 鄭丹寧, 李青峰, 等. 自體脂肪移植綜合技術(shù)在面部輪廓整形中的應(yīng)用. 中華整形外科雜志, 2010, 26(3): 178-181.
  44. 44. Coleman SR. Hand rejuvenation with structural fat grafting. Plast Reconstr.
  45. 45. Coleman SR. Stuctional fat grafting. Dermatologic Surg, 2005, 31: 1714.
  46. 46. 謝蕓, 鄭丹寧, 李青峰. 自體脂肪移植在顳部分層填充治療的應(yīng)用. 中國美容整形外科雜志, 2010, 21(9): 515-517.
  47. 47. Trepsat F. Periorbital rejuvenation combining fat grafting and blepharoplasties.
  48. 48. 鄭丹寧, 謝蕓, 李青峰. 面部脂肪移植并發(fā)癥的預(yù)防. 中國美容醫(yī)學(xué), 2007, 16(4): 574-576.
  49. 49. Ohara H, Kishi K, Nakajima T. The unilocular fat-cell graft. J Plast Reconstr.