• 南京中醫(yī)藥大學(xué)附屬中西醫(yī)結(jié)合鼓樓臨床醫(yī)學(xué)院ICU( 江蘇南京 210008);

感染性疾病的發(fā)病率高, 給社會(huì)經(jīng)濟(jì)帶來(lái)沉重負(fù)擔(dān), 感染性疾病的早期診斷和治療對(duì)提高臨床療效和降低死亡率有重要意義。髓樣細(xì)胞觸發(fā)性受體1 ( triggering receptor-1
expressed on myeloid cells, TREM-1) 在炎癥反應(yīng)的發(fā)生發(fā)展過(guò)程中起著重要的作用。Bouchon 等[ 1] 在2000 年首先發(fā)現(xiàn)TREM-1 選擇性表達(dá)于中性粒細(xì)胞、CD14 + 單核細(xì)胞膜表面。后來(lái)的研究發(fā)現(xiàn)TREM-1 也表達(dá)于上皮細(xì)胞、多核巨細(xì)胞、腹膜巨噬細(xì)胞、淋巴結(jié)巨噬細(xì)胞、肺泡巨噬細(xì)胞, 纖維肉瘤細(xì)胞膜表面[ 2-5] 。人的TREM-1 由胞外區(qū)、跨膜區(qū)、胞漿區(qū)共同組成, 跨膜區(qū)含有1 個(gè)帶正電荷的賴氨酸殘基, 它可與接頭蛋白DAP12 跨膜區(qū)內(nèi)的帶負(fù)電荷的天冬氨酸相偶聯(lián), 并通過(guò)胞漿區(qū)中的免疫受體酪氨酸活化基序( ITAM) 來(lái)激活下游信號(hào)傳導(dǎo), 促進(jìn)促炎因子的分泌[ 6] 。TREM-1 激發(fā)、放大炎癥反應(yīng)的同時(shí)促進(jìn)抗炎因子的下調(diào)[ 1, 2, 7] 。‥‥‥

引用本文： 楊樸強(qiáng),顧勤,劉寧,虞竹溪. 可溶性髓樣細(xì)胞觸發(fā)性受體1 對(duì)感染性疾病的診斷價(jià)值. 中國(guó)呼吸與危重監(jiān)護(hù)雜志, 2010, 9(2): 213-215. doi: 復(fù)制

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1. Bouchon A, Dietrich J, Colonna M, et al. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol, 2000, 164 : 4991-4995.
2. Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature,2001, 410 : 1103-1107.
3. Colonna M, Facchetti F. TREM-1 ( triggering receptor expressed on myeloid cells) : a new player in acute inflammatory responses. J Infect Dis, 2003, 187: S397-S401 .
4. Allcock RJ, Barrow AD, Forbes S, et al. The human TREM gene cluster at 6 p21 . 1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol, 2003, 33 :567 -577.
5. Schenk M, Bouchon A, Birrer S, et al. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol, 2005 , 174 :517 -524.
6. Kelker MS, Foss TR, Peti W, et al. Crystal structure of human triggering receptor expressed on myeloid cells 1 ( TREM-1) at1 . 47 A. J Mol Biol, 2004, 342: 1237-1248.
7. Bleharski JR, Kiessler V, Buonsanti C, et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol, 2003 , 170: 3812-3818.
8. Góomez-Pi a V, Soares-Schanoski A, Rodríguez-Rojas A, et al.Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol, 2007 ,179 : 4065 -4073 .
9. Gibot S, Cravoisy A, Levy B, et al. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. NEngl J Med, 2004, 350: 451 -8.
10. Huh JW, Lim CM, Koh Y, et al. Diagnostic utility of the soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid from patients with bilateral lung infiltrates. Critical Care, 2008, 12: R6 .
11. Horonenko G, Hoyt JC, Robbins RA, et al. Soluble Triggering Receptor Expressed on Myeloid Cell-1 Is Increased in Patients With Ventilator-Associated Pneumonia. Chest, 2007 , 132: 58-63 .
12. Anand NJ, Zuick S, Klesney-Tait J, et al. Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU. Chest, 2009, 135 :641 -647.
13. Tejera A, Santolaria F, Diez M, et al. Prognosis of community acquired pneumonia ( CAP) : Value of triggering receptor expressed on myeloid cells-1 ( TREM-1 ) and other mediators of the inflammatory response. Cytokine, 2007 , 38: 117-123.
14. Determann RM, Millo JL, Gibot S, et al. Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med, 2005, 31: 1495-1500 .
15. Phua J, Koay ES, Zhang D, et al. Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections. Eur Respir J, 2006, 28 : 695-702.
16. Gibot S, Cravoisy A. Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin Med Res, 2004, 2 : 181-187.
17. Kofoed K, Andersen O, Kronborg G, et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble- urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care,.
18. Jiyong J, Tiancha H, Cui Wei, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med, 2009 , 35: 587-595.
19. Bishara J, Hadari M, Shalita-Chesner Z, et al. Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults. Eur J Clin Microbiol Infect Dis,2007, 26: 647-650 .
20. Determann RM, Weisfelt M, Gans J, et al. Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis. Intensive Care Med, 2006 , 32: 1243-1247.
21. Chan MC, Chang KM, Chao WC, et al. Evaluation of a new inflammatory molecule ( triggering receptor expressed on myeloid cells-1) in the diagnosis of pleural effusion. Respirology, 2007 ,12: 333-338 .
22. HUANG LZ, SHI HZ, LIANG QL, et al. Expression of soluble triggering receptor expression on myeloid cells-1 in pleural effusion. Chin Med J( Engl) , 2008, 121: 1656 -1661 .
23. Tzivras M, Koussoulas V, Giamarellos-Bourboulis EJ, et al. Role of soluble triggering receptor expressed on myeloid cells In inflammatory bowel disease. World J Gastroenterol, 2006, 12 : 3416 -3419.
24. Yasuda T, Takeyama Y, Ueda T, et al. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis, Crit Care Med, 2008, 36: 2048-2053.
25. , 11: R38.
  1. 1. Bouchon A, Dietrich J, Colonna M, et al. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol, 2000, 164 : 4991-4995.
  2. 2. Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature,2001, 410 : 1103-1107.
  3. 3. Colonna M, Facchetti F. TREM-1 ( triggering receptor expressed on myeloid cells) : a new player in acute inflammatory responses. J Infect Dis, 2003, 187: S397-S401 .
  4. 4. Allcock RJ, Barrow AD, Forbes S, et al. The human TREM gene cluster at 6 p21 . 1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol, 2003, 33 :567 -577.
  5. 5. Schenk M, Bouchon A, Birrer S, et al. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol, 2005 , 174 :517 -524.
  6. 6. Kelker MS, Foss TR, Peti W, et al. Crystal structure of human triggering receptor expressed on myeloid cells 1 ( TREM-1) at1 . 47 A. J Mol Biol, 2004, 342: 1237-1248.
  7. 7. Bleharski JR, Kiessler V, Buonsanti C, et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol, 2003 , 170: 3812-3818.
  8. 8. Góomez-Pi a V, Soares-Schanoski A, Rodríguez-Rojas A, et al.Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol, 2007 ,179 : 4065 -4073 .
  9. 9. Gibot S, Cravoisy A, Levy B, et al. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. NEngl J Med, 2004, 350: 451 -8.
  10. 10. Huh JW, Lim CM, Koh Y, et al. Diagnostic utility of the soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid from patients with bilateral lung infiltrates. Critical Care, 2008, 12: R6 .
  11. 11. Horonenko G, Hoyt JC, Robbins RA, et al. Soluble Triggering Receptor Expressed on Myeloid Cell-1 Is Increased in Patients With Ventilator-Associated Pneumonia. Chest, 2007 , 132: 58-63 .
  12. 12. Anand NJ, Zuick S, Klesney-Tait J, et al. Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU. Chest, 2009, 135 :641 -647.
  13. 13. Tejera A, Santolaria F, Diez M, et al. Prognosis of community acquired pneumonia ( CAP) : Value of triggering receptor expressed on myeloid cells-1 ( TREM-1 ) and other mediators of the inflammatory response. Cytokine, 2007 , 38: 117-123.
  14. 14. Determann RM, Millo JL, Gibot S, et al. Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med, 2005, 31: 1495-1500 .
  15. 15. Phua J, Koay ES, Zhang D, et al. Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections. Eur Respir J, 2006, 28 : 695-702.
  16. 16. Gibot S, Cravoisy A. Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin Med Res, 2004, 2 : 181-187.
  17. 17. Kofoed K, Andersen O, Kronborg G, et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble- urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care,.
  18. 18. Jiyong J, Tiancha H, Cui Wei, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med, 2009 , 35: 587-595.
  19. 19. Bishara J, Hadari M, Shalita-Chesner Z, et al. Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults. Eur J Clin Microbiol Infect Dis,2007, 26: 647-650 .
  20. 20. Determann RM, Weisfelt M, Gans J, et al. Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis. Intensive Care Med, 2006 , 32: 1243-1247.
  21. 21. Chan MC, Chang KM, Chao WC, et al. Evaluation of a new inflammatory molecule ( triggering receptor expressed on myeloid cells-1) in the diagnosis of pleural effusion. Respirology, 2007 ,12: 333-338 .
  22. 22. HUANG LZ, SHI HZ, LIANG QL, et al. Expression of soluble triggering receptor expression on myeloid cells-1 in pleural effusion. Chin Med J( Engl) , 2008, 121: 1656 -1661 .
  23. 23. Tzivras M, Koussoulas V, Giamarellos-Bourboulis EJ, et al. Role of soluble triggering receptor expressed on myeloid cells In inflammatory bowel disease. World J Gastroenterol, 2006, 12 : 3416 -3419.
  24. 24. Yasuda T, Takeyama Y, Ueda T, et al. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis, Crit Care Med, 2008, 36: 2048-2053.
  25. 25. , 11: R38.