• 南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院呼吸科（江蘇南京 210008）;

骨化性氣管支氣管病( tracheobronchopathia osteochondroplastica,TPO 或TO) , 是一種罕見的氣管內(nèi)膜系統(tǒng)的良性病變, 主要以氣管和主支氣管黏膜下多發(fā)性骨和軟骨組織結(jié)節(jié)狀增生為特征, 通常引起氣道狹窄[ 1] 。大多數(shù)患者沒有臨床癥狀, 因此易被誤診和漏診。本文將TO 的臨床特征做一綜述, 以提高對該病的認(rèn)識。

引用本文： 曹孟淑,蔡后榮. 骨化性氣管支氣管病的臨床特征. 中國呼吸與危重監(jiān)護(hù)雜志, 2009, 09(3): 307-309. doi: 復(fù)制

1. Baran A, Güng　r S, Unver E, et al. Tracheobronchopathia osteochondroplastica: a case report. Tuberk Toraks, 2004 , 52: 183 -185.
2. Wilks S. Ossific deposits in the larynx, trachea and bronchi. Trans Pathol Soc Lond, 1857, 8: 88.
3. Prakash UB. Tracheobronchopathia osteochondroplastica. Semin Respir Crit Care Med, 2002, 23: 167-175.
4. Jabbardarjani HR, Radpey B, Kharabian S, et al. Tracheobronchopathia osteochondroplastica: presentation of ten cases and review of the literature. Lung, 2008, 186: 293-297.
5. Willms H, Wiechmann V, Sack U, et al. Tracheobronchopathia osteochondroplastica: A rare cause of chronic cough with haemoptysis. Cough, 2008 , 4: 4.
6. Simsek PO, Ozcelik U, Demirkazik F, et al. Tracheobronchopathia osteochondroplastica in a 9-year-old girl. Pediatr Pulmonol, 2006 ,41: 95-97.
7. Zack JR, Rozenshtein A. Tracheobronchopathia osteochondroplastica:report of three cases. J Comput Assist Tomogr, 2002, 26 : 33 -36.
8. Matsuba T, Komori M, Matsunaga R, et al. A case of tracheobronchopathia osteochondroplastica: diagnosed by fiberoptic bronchoscopy upon removal of an aspirated crown. Diagn Ther Endosc, 2001, 7: 63-67.
9. Co　tmeur D, Bovyn G, Leroux P, et al. Tracheobronchopathia osteochondroplastica presenting at the time of a difficult intubation.Respir Med, 1997, 91: 496-498.
10. Tadjeddein A, Khorgami Z, Akhlaghi H. Tracheobronchopathia osteoplastica: cause of difficult tracheal intubation. Ann Thorac Surg, 2006, 81: 1480-1482.
11. Vilkman S, Keistinen T. Tracheobronchopathia osteochondroplastica.Report of a young man with severe disease and retrospective review of 18 cases. Respiration, 1995, 62: 151-154.
12. Marchesani F, Staccioli D, Pela R, et al. Tracheobronchopathia osteochondroplastica. Monaldi Arch Chest Dis, 1993, 48: 210-212.
13. Pinheiro GA, Antao VC, Müller NL. Tracheobronchopathia osteochondroplastica in a patient with silicosis: CT, bronchoscopy,and pathology findings. J Comput Assist Tomogr, 2004, 28: 801- 803.
14. Barthwal MS, Chatterji RS, Mehta A. Tracheobronchopathia osteochondroplastica. Indian J Chest Dis Allied Sci, 2004, 46: 43 -46.
15. Karlikaya C, Yüksel M, Kilicli S, et al. Tracheobronchopathia osteochondropla-stica. Respirology, 2000, 5: 377-380.
16. Leske V, Lazor R, Coetmeur D, et al. Tracheobronchopathia osteochondroplastica: a study of 41 patients. Medicine ( Baltimore) ,2001, 80: 378-390.
17. Hantous-Zannad S, Seba　L, Zidi A, et al. Tracheobronchopathia osteochondroplastica presenting as a respiratory insufficiency:diagnosis by bronchoscopy and MRI. Eur J Radiol, 2003, 45: 113 -116.
18. White BD, Kong A, Khoo E, et al. Computed tomography diagnosis of tracheobronchopathia steochondroplastica. Australas Radiol,2005, 49: 319-321.
19. Lundgren R, Stjernberg NL. Tracheobronchopathia osteochondroplastica.A clinical bronchoscopic and spirometric study. Chest, 1981 ,80: 706-709.
20. Wong JS, Ng CS, Yim AP. Hemoptysis with multiple tracheal nodules. Chest, 2005, 128: 3671-3673.
21. Shigematsu Y, Sugio K, Yasuda M, et al. Tracheobronchopathia osteochondroplastica occurring in a subsegmental bronchus and causing obstructive pneumonia. Ann Thorac Surg, 2005, 80: 1936-1938.
22. Tukiainen H, Torkko M, Terho EO. Lung function in patients with tracheobronchopathia osteochondroplastica. Eur Respir J, 1988 , 1 :632-635.
23. 李時悅, 歐陽能太, 鐘南山. 骨化性氣管支氣管病. 中華結(jié)核和呼吸雜志, 2001, 24: 414-416.
  1. 1. Baran A, Güng　r S, Unver E, et al. Tracheobronchopathia osteochondroplastica: a case report. Tuberk Toraks, 2004 , 52: 183 -185.
  2. 2. Wilks S. Ossific deposits in the larynx, trachea and bronchi. Trans Pathol Soc Lond, 1857, 8: 88.
  3. 3. Prakash UB. Tracheobronchopathia osteochondroplastica. Semin Respir Crit Care Med, 2002, 23: 167-175.
  4. 4. Jabbardarjani HR, Radpey B, Kharabian S, et al. Tracheobronchopathia osteochondroplastica: presentation of ten cases and review of the literature. Lung, 2008, 186: 293-297.
  5. 5. Willms H, Wiechmann V, Sack U, et al. Tracheobronchopathia osteochondroplastica: A rare cause of chronic cough with haemoptysis. Cough, 2008 , 4: 4.
  6. 6. Simsek PO, Ozcelik U, Demirkazik F, et al. Tracheobronchopathia osteochondroplastica in a 9-year-old girl. Pediatr Pulmonol, 2006 ,41: 95-97.
  7. 7. Zack JR, Rozenshtein A. Tracheobronchopathia osteochondroplastica:report of three cases. J Comput Assist Tomogr, 2002, 26 : 33 -36.
  8. 8. Matsuba T, Komori M, Matsunaga R, et al. A case of tracheobronchopathia osteochondroplastica: diagnosed by fiberoptic bronchoscopy upon removal of an aspirated crown. Diagn Ther Endosc, 2001, 7: 63-67.
  9. 9. Co　tmeur D, Bovyn G, Leroux P, et al. Tracheobronchopathia osteochondroplastica presenting at the time of a difficult intubation.Respir Med, 1997, 91: 496-498.
  10. 10. Tadjeddein A, Khorgami Z, Akhlaghi H. Tracheobronchopathia osteoplastica: cause of difficult tracheal intubation. Ann Thorac Surg, 2006, 81: 1480-1482.
  11. 11. Vilkman S, Keistinen T. Tracheobronchopathia osteochondroplastica.Report of a young man with severe disease and retrospective review of 18 cases. Respiration, 1995, 62: 151-154.
  12. 12. Marchesani F, Staccioli D, Pela R, et al. Tracheobronchopathia osteochondroplastica. Monaldi Arch Chest Dis, 1993, 48: 210-212.
  13. 13. Pinheiro GA, Antao VC, Müller NL. Tracheobronchopathia osteochondroplastica in a patient with silicosis: CT, bronchoscopy,and pathology findings. J Comput Assist Tomogr, 2004, 28: 801- 803.
  14. 14. Barthwal MS, Chatterji RS, Mehta A. Tracheobronchopathia osteochondroplastica. Indian J Chest Dis Allied Sci, 2004, 46: 43 -46.
  15. 15. Karlikaya C, Yüksel M, Kilicli S, et al. Tracheobronchopathia osteochondropla-stica. Respirology, 2000, 5: 377-380.
  16. 16. Leske V, Lazor R, Coetmeur D, et al. Tracheobronchopathia osteochondroplastica: a study of 41 patients. Medicine ( Baltimore) ,2001, 80: 378-390.
  17. 17. Hantous-Zannad S, Seba　L, Zidi A, et al. Tracheobronchopathia osteochondroplastica presenting as a respiratory insufficiency:diagnosis by bronchoscopy and MRI. Eur J Radiol, 2003, 45: 113 -116.
  18. 18. White BD, Kong A, Khoo E, et al. Computed tomography diagnosis of tracheobronchopathia steochondroplastica. Australas Radiol,2005, 49: 319-321.
  19. 19. Lundgren R, Stjernberg NL. Tracheobronchopathia osteochondroplastica.A clinical bronchoscopic and spirometric study. Chest, 1981 ,80: 706-709.
  20. 20. Wong JS, Ng CS, Yim AP. Hemoptysis with multiple tracheal nodules. Chest, 2005, 128: 3671-3673.
  21. 21. Shigematsu Y, Sugio K, Yasuda M, et al. Tracheobronchopathia osteochondroplastica occurring in a subsegmental bronchus and causing obstructive pneumonia. Ann Thorac Surg, 2005, 80: 1936-1938.
  22. 22. Tukiainen H, Torkko M, Terho EO. Lung function in patients with tracheobronchopathia osteochondroplastica. Eur Respir J, 1988 , 1 :632-635.
  23. 23. 李時悅, 歐陽能太, 鐘南山. 骨化性氣管支氣管病. 中華結(jié)核和呼吸雜志, 2001, 24: 414-416.

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