目的 研究居室內(nèi)溫度及相對濕度對COPD急性加重(AECOPD)的影響。方法 選擇7O例中度到極重度COPD患者,采用記錄日記卡的形式,收集患者2005年1月~12月間每日早晚2次居室內(nèi)溫度和相對濕度,以及每日呼吸困難程度、痰量、痰性、咳嗽、感冒癥狀、咽痛、用藥調(diào)整等臨床事件評分資料,進行統(tǒng)計學(xué)分析。同時,將2005年同期每日室外平均溫度、相對濕度、大氣壓資料與室內(nèi)資料相比較,研究室內(nèi)和室外環(huán)境因素對AECOPD影響程度的差異。結(jié)果 最終有55例完成全部研究。采用Logistic回歸法分析室內(nèi)溫濕度對AECOPD的影響,溫度和濕度最后皆人選。室內(nèi)外溫濕度及大氣壓與AECOPD均有顯著關(guān)聯(lián)(P均 lt;0.05)。在相關(guān)強度上,室內(nèi)溫度(r=-0.686) gt;室外溫度(r=-0.671),室內(nèi)濕度與AECOPD呈正相關(guān)(r=0.105),而室外濕度與AECOPD呈負相關(guān)(r=-0.115),大氣壓與AECOPD呈正相關(guān)(r=0.545)。結(jié)論 室內(nèi)溫度和相對濕度,特別是低溫和高濕度對中度以上AECOPD的發(fā)生有明顯的影響。與室外環(huán)境相比,室內(nèi)溫度和濕度與AECOPD的關(guān)系更為密切。因此,調(diào)節(jié)室內(nèi)溫濕度可能有助于減少AECOPD的發(fā)生。
引用本文: 謝國鋼,金先橋. 室內(nèi)環(huán)境對慢性阻塞性肺疾病急性加重的影響. 中國呼吸與危重監(jiān)護雜志, 2008, 08(5): 358-362. doi: 復(fù)制
1. | 趙鳴武,重視對慢性阻塞性肺疾病急性加重的病因?qū)W及其對策的研究.中國呼吸與危重監(jiān)護雜志,2004,3:67. |
2. | . 劉春濤,馮玉麟.慢性阻塞性肺疾病急性加重研究進展.中國呼吸與危重監(jiān)護雜志,2007,6:413-415. |
3. | Fabbri LM,Hurd SS.Global strategy for the diagnosis,management and prevention of COPD:2003 update.Eur Respir J,2003,22:1-2. |
4. | Anthonisen NR,Manfreda J,Warren CP,et al.Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease.Ann Intern Med,1987,106:196-204. |
5. | Edwin K.Exacerbations in Chronic Obstructive Pulmonary Disease:Do They Contribute to Disease Progression? Proc Am Thorac Soc,2007,4:586-590. |
6. | Seemungal TAR,Donaldson GC,Paul EA,et al.Rrelationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease.Thorax,2002,57:847-852. |
7. | Seemungal TA,Donaldson GC,Bhowmik A,et al.Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease.Am J Resp ir Crit Care Med,2000,161:1608-1613. |
8. | Donaldson GC,Wedzicha JA.COPD exacerbations.1:epidemiology.Thorax,2006,61:164-168. |
9. | Koskela H,Jussi P,Heikki P,et al.Effect of cold air on exercise capacity in COPD.Chest,1998,113:1560–1565. |
10. | 曾運紅,郭蘭萍,張羽,等.慢性阻塞性肺疾病發(fā)病住院與氣候因素的關(guān)系.廣東醫(yī)學(xué),2003,24:1230-1231. |
11. | Donaldson GC,Seemungal T,Jeffries DJ,et al.Effect of environmental temperature on symptoms,lung function and mortality in COPD patients.Eur Respir J,1999,13:844–849. |
- 1. 趙鳴武,重視對慢性阻塞性肺疾病急性加重的病因?qū)W及其對策的研究.中國呼吸與危重監(jiān)護雜志,2004,3:67.
- 2. . 劉春濤,馮玉麟.慢性阻塞性肺疾病急性加重研究進展.中國呼吸與危重監(jiān)護雜志,2007,6:413-415.
- 3. Fabbri LM,Hurd SS.Global strategy for the diagnosis,management and prevention of COPD:2003 update.Eur Respir J,2003,22:1-2.
- 4. Anthonisen NR,Manfreda J,Warren CP,et al.Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease.Ann Intern Med,1987,106:196-204.
- 5. Edwin K.Exacerbations in Chronic Obstructive Pulmonary Disease:Do They Contribute to Disease Progression? Proc Am Thorac Soc,2007,4:586-590.
- 6. Seemungal TAR,Donaldson GC,Paul EA,et al.Rrelationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease.Thorax,2002,57:847-852.
- 7. Seemungal TA,Donaldson GC,Bhowmik A,et al.Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease.Am J Resp ir Crit Care Med,2000,161:1608-1613.
- 8. Donaldson GC,Wedzicha JA.COPD exacerbations.1:epidemiology.Thorax,2006,61:164-168.
- 9. Koskela H,Jussi P,Heikki P,et al.Effect of cold air on exercise capacity in COPD.Chest,1998,113:1560–1565.
- 10. 曾運紅,郭蘭萍,張羽,等.慢性阻塞性肺疾病發(fā)病住院與氣候因素的關(guān)系.廣東醫(yī)學(xué),2003,24:1230-1231.
- 11. Donaldson GC,Seemungal T,Jeffries DJ,et al.Effect of environmental temperature on symptoms,lung function and mortality in COPD patients.Eur Respir J,1999,13:844–849.