重癥肺炎是造成重癥加強(qiáng)治療病房(ICU)患者死亡的主要原因之一[1]。前白蛋白(PA)是肝臟合成的負(fù)性急性時(shí)相蛋白,半衰期短,能準(zhǔn)確地反映肝臟損害的程度,但在評(píng)價(jià)患者預(yù)后及嚴(yán)重性方面還存在有爭(zhēng)議[2,3]。故此,本研究通過(guò)動(dòng)態(tài)觀測(cè)重癥肺炎患者PA變化,探討其與病情嚴(yán)重程度及預(yù)后的關(guān)系。
引用本文: 章車(chē)明,張琳. 重癥肺炎患者血清前白蛋白的動(dòng)態(tài)變化及臨床意義. 中國(guó)呼吸與危重監(jiān)護(hù)雜志, 2008, 08(2): 142-142. doi: 復(fù)制
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- 1. Niederman MS,Mandell LA,Anzueto A,et al.Guidelines for the management of adults with community-acquired pneumonia.Diagnosis,assessment of severity,antimicrobial therapy,and prevention.Am J Respir Crit Care Med,2001,163:1730-1754.
- 2. 姚泰,主編.生理學(xué).北京:人民衛(wèi)生出版社,2005,374.
- 3. Lim SH,Lee JS,Chae SH,et al.Prealbumin is not sensitive indicator of nutrition and prognosis in critical ill patients.Yonsei Med J,2005,46:21-26.
- 4. 王昆,王瑾,王珊珊.亞胺培南/西司他丁對(duì)重癥肺炎的降階梯治療療效分析.中華醫(yī)院感染學(xué)雜志,2005,15:805-807.
- 5. Devoto G,Gallo F,Marchello C,et al.Prealbumin serum levels as a useful tool in the assessment of malnutrition in hospitalized patients.Clin Chem,2006,52:2281-2285.
- 6. Pinilla JC,Hayes P,Laverty W,et al The C-reactive protein to prealbumin ratio correlates with the severity of multiple organ dysfunction.Surgery,1998,124,799-805.
- 7. Chertow GM,Goldstein-Fuchs DJ,Lazarus JM,et al.Prealbumin,mortality,and cause-specific hospitalization in hemodialysis patients.Kidney Int,2005,68:2794-2800.