支氣管擴(kuò)張癥(簡(jiǎn)稱支擴(kuò))是一種慢性肺部疾病,特征性地表現(xiàn)為支氣管異常、持久的擴(kuò)張和破壞,臨床處理困難。雖然支擴(kuò)的病因多種多樣,但細(xì)菌性感染和持續(xù)性炎癥是其典型病變,且反復(fù)發(fā)生,導(dǎo)致病情不斷惡化。臨床表現(xiàn)主要為發(fā)熱、咯膿性痰,并常伴有胸痛和咯血。在支擴(kuò)患者的痰中最常分離培養(yǎng)出的細(xì)菌是流感嗜血桿菌、肺炎鏈球菌、金黃色葡萄球菌和銅綠假單胞菌,其中銅綠假單胞菌是病程晚期最常見也是最難處理的感染病原體,往往難以清除,并與病情的加重和惡化密切相關(guān),與其他病原體感染相比可導(dǎo)致更快的肺功能和生活質(zhì)量的下降[1]。
引用本文: 施毅. 霧化吸入抗生素在支氣管擴(kuò)張癥中的應(yīng)用. 中國呼吸與危重監(jiān)護(hù)雜志, 2007, 6(3): 163-165. doi: 復(fù)制
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- 1. Barker AF,Couch L,F(xiàn)iel TB,et al. Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis.Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):481-5.
- 2. Couch LA. Treatment With tobramycin solution for inhalation in bronchiectasis patients with Pseudomonas aeruginosa.Chest. 2001 Sep;120(3 Suppl):114S-117S.
- 3. Kuhn RJ. Formulation of aerosolized therapeutics.,2001,120():94s-98s.
- 4. Campbell PW 3rd, Saiman L. Use of aerosolized antibiotics in patients with cystic fibrosis..Chest,1999,116():775-788.
- 5. Scheinberg P,Shore E. A pilot study of the safety and efficacy of tobramycin solution for inhalation in patients with severe bronchiectasis..Chest,2005,127:1420-1426.
- 6. Falagas ME,Siempos II,Bliziotis IA,et al. Administration of antibiotics via the respiratory tract for the prevention of ICU-acquired pneumonia: a meta-analysis of comparative trials.Crit Care,2006,10(4):R123.