通過同位素交換反應(yīng)將131I標(biāo)記到碘化油分子上,其標(biāo)記率在95%以上,室溫下放置15天及高壓滅菌后未見有脫碘現(xiàn)象。γ-照相顯示131I—碘化油注入狗的肝動(dòng)脈后,僅選擇性地蓄積于注入的肝葉內(nèi),甲狀腺、肺等其它部位未見核素蓄積。131I—碘化油在肝內(nèi)的有效關(guān)衰期為4.92±0.66天。每毫升血液放射性為注入量的0.09±0.04%。提示131I—碘化油性能穩(wěn)定,適宜臨床應(yīng)用。
引用本文: 王自法,潘承恩,胡國瑛. 131I—碘化油肝動(dòng)脈栓塞的實(shí)驗(yàn)研究. 中國普外基礎(chǔ)與臨床雜志, 1995, 2(1): 8-10. doi: 復(fù)制
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- 1. 王自法,潘承恩.肝血管栓塞治療肝癌的進(jìn)展.普外臨床,1993;8(3):176.
- 2. Madsan MT, Park, CH, Thakur ML. Dosimety of iodinl-131 ethiodol in the treatment of hepatoma. J Nucl Med,1988;29:1038.
- 3. 潘承恩,李寶生,王自法等.川狗肝解剖研究.中華實(shí)驗(yàn)外科雜志,1991;3:182.
- 4. Miller DL, O’Leary TJ, Girton M. DIstribution of io dined oil within the liver after hepatic arterial injection. Radiology, 1987;162:849.
- 5. Labayashi H, Inoue H, Shimada J. Intraarterial injection of AMD/MMC lipiodol suspension in liver matastases. Acta Radiogic, 1987;28:275.
- 6. 小林尚志,中政敬.Radioactive Lipiodol Transcatheter Arterial Embolization .日本醫(yī)學(xué)放射學(xué)會(huì)雜志,1984;44(1):96.
- 7. 王自法,潘承恩,胡國瑛.〔131〕I—碘化油肝動(dòng)脈栓塞、內(nèi)照射治療肝癌.實(shí)用腫瘤學(xué)雜志,1991;5(3):80.