• 南京軍區(qū)福州總醫(yī)院普外科(福州350001);

用犬制作膽道梗阻模型，觀察梗阻后不同時相犬十二指腸和回盲部需氧菌的變化，并對其腸壁進行組織學與超微結構觀察，以探討膽道梗阻對小腸菌群的影響和腸道菌群在膽道感染等內源性感染中的作用。結果顯示：隨犬膽道梗阻時間的延長，小腸菌群發(fā)生不同程度的變化，表現(xiàn)為細菌的輕度增殖，定殖菌種數(shù)增多，下段小腸細菌（主要是大腸桿菌）移位到十二指腸，使十二指腸內總需氧菌和大腸桿菌的定殖率明顯增高；回腸粘膜充血水腫、炎細胞浸潤、上皮微絨毛減少。破環(huán)等病理改變。由此表明，膽道梗阻時腸菌失調和腸粘膜屏障的破環(huán)可能與膽道梗阻時膽道感染發(fā)生率高有著密切關系。因此臨床上在及時解除膽道梗阻的同時，還應注意調整膽道梗阻患者的腸道菌群平衡，阻止下消化道細菌上行定植，以防止腸源性感染的發(fā)生。

引用本文： 江藝,吳愛平. 膽道梗阻對犬小腸菌群的影響. 中國普外基礎與臨床雜志, 1995, 2(3): 132-135. doi: 復制

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  1. 1. Stacey M,Webb M.Stadies on the antibacterial properties of the acids and some compounds derived from cholanic acid.Proc Roy Soc,1947;134:523.
  2. 2. Burke V,Stone DE,Beaman J,Gracey M.Effects of biliary diversion on intestinal microflora in the rat.J Med Microbiol,1977;10:244.
  3. 3. Sacquet E,Raibaud D.Etude comparee de la microflora de Ⅰ’ estomac, de Ⅰ’ intestin grele et du caecum du rat holoxenique,et de ses modifications a la suite de diverses,interventions chirurgicales:anse avengle jejunale,deviations biliaires.Annle Inst Pasteus Paris,1971;121:501.
  4. 4. Brown WR,Savage DC,Dubois RS,et al.Intestinal microflora of immunoglobulin-deficient and human subjects.Gastroenterol,1972;62:1143.
  5. 5. Deitch EA,Sttig K,Ma Li,et al.Obstructive jaundice promotes bacterial translocation from the gut.Am J Surg,1990;159:79.
  6. 6. Househam KC.Duodenal microflora in infants with acute diarrheal diease.J Padiatr Gastroenterol Nutr,1986;5:721.