為探討組織蛋白酶B在急性胰腺炎(AP)發(fā)病中的作用,對(duì)11只急性水腫性胰腺炎犬和12只急性出血壞死性胰腺炎犬(AHNP)的胰腺腺泡細(xì)胞內(nèi)組織蛋白酶B的分布情況進(jìn)行了檢測(cè),并與7只正常犬進(jìn)行比較。結(jié)果:實(shí)驗(yàn)犬AP早期即有胰腺腺泡細(xì)胞內(nèi)組織蛋白酶B的再分布現(xiàn)象,AHNP犬尤為明顯(P<0.01)。由此表明,組織蛋白酶B在AP的發(fā)病中具有一定的作用。
引用本文: 王茂旭,劉厚東,曾嶸,李素芝,田伏洲. 組織蛋白酶B在急性胰腺炎發(fā)病中的作用探討. 中國(guó)普外基礎(chǔ)與臨床雜志, 1998, 5(6): 338-339. doi: 復(fù)制
1. | Mc Donald JK, Ellis. In the substrate specificity of cathepsin B1 and B2 including a new flurogonic substrate for cathepsin B1. Life Sci, 1975; 17∶1269. |
2. | Lombardi B, Estes LW, Longnecker DS. Acute hemorrhagic pancreatitis (cmassive necrosis) with fat necrosis induced in mice by dlehionine fed with a cholinedeficient diet. Am J Pathol, 1975; 79∶465. |
3. | Bialek R, Willemer S, Arnold R, et al. Evidence of intracellular activation of serumproteases in acute ceruleininduced pancreatitis in rats. Scand J Gastroenterol, 1991; 26∶130. |
4. | Ohshio G, Saluja A, Steer ML. Effects of shortterm pancreatic duct obstruction in rats. Gastroenterology, 1991; 199∶196. |
5. | Steer ML. Pathognesis of acute pancreatitis. Ann Rev Med, 1988; 39∶95. |
6. | Hirano T, Manake T, Yotsumoto F, et al. Effect of prostaglandin E on the restistribution of lysosomal enzyme in ceruleininduced pancreatitis. Hepatogastroenterology, 1993; 40∶155. |
- 1. Mc Donald JK, Ellis. In the substrate specificity of cathepsin B1 and B2 including a new flurogonic substrate for cathepsin B1. Life Sci, 1975; 17∶1269.
- 2. Lombardi B, Estes LW, Longnecker DS. Acute hemorrhagic pancreatitis (cmassive necrosis) with fat necrosis induced in mice by dlehionine fed with a cholinedeficient diet. Am J Pathol, 1975; 79∶465.
- 3. Bialek R, Willemer S, Arnold R, et al. Evidence of intracellular activation of serumproteases in acute ceruleininduced pancreatitis in rats. Scand J Gastroenterol, 1991; 26∶130.
- 4. Ohshio G, Saluja A, Steer ML. Effects of shortterm pancreatic duct obstruction in rats. Gastroenterology, 1991; 199∶196.
- 5. Steer ML. Pathognesis of acute pancreatitis. Ann Rev Med, 1988; 39∶95.
- 6. Hirano T, Manake T, Yotsumoto F, et al. Effect of prostaglandin E on the restistribution of lysosomal enzyme in ceruleininduced pancreatitis. Hepatogastroenterology, 1993; 40∶155.