為了降低移植物免疫原性,誘導(dǎo)免疫耐受,本實(shí)驗(yàn)采用單抗加補(bǔ)體方法消除大鼠甲狀旁腺移植物中的主要組織相容性Ⅰ類抗原(Ⅰa)陽性細(xì)胞,將其移植到同種受體腎包膜下,觀察移植物平均存活時(shí)間。結(jié)果顯示:處理組移植物平均存活時(shí)間為60天,對(duì)照組為14天,兩者相比有極顯著性差異(P<0.01)。說明消除Ⅰa抗原陽性細(xì)胞可顯著延長大鼠甲狀旁腺同種異體移植物存活時(shí)間。
引用本文: 張?zhí)?朱預(yù),王樹慧,張?jiān)?肖毅. 消除主要組織相容性Ⅰ類抗原陽性細(xì)胞延長大鼠甲狀旁腺同種異體移植物存活期. 中國普外基礎(chǔ)與臨床雜志, 1998, 5(5): 263-264下轉(zhuǎn)269. doi: 復(fù)制
版權(quán)信息: ?四川大學(xué)華西醫(yī)院華西期刊社《中國普外基礎(chǔ)與臨床雜志》版權(quán)所有,未經(jīng)授權(quán)不得轉(zhuǎn)載、改編
1. | Lafferty KJ, Prowse SJ, Simeonovic CJ. Immunobiology of tissue transplantation: a return to the passenger leukocyte concept. Ann Rev Immunol, 1983; 1(1)∶143. |
2. | 羅江明.甲狀旁腺同種異體移植.中華器官移植雜志,1987; 8(1)∶45. |
3. | Faustman D, Hauptfeld V, Lacy PE, et al. Prolongation of murine islet allograft by pretreatment of islets with antibody directed to Ⅰa determinants. Proc Natl Acad Sci USA, 1981; 78(6)∶5156. |
4. | 羅江明,朱預(yù).高氧培養(yǎng)甲狀旁腺對(duì)大鼠同種移植腺體存活時(shí)間的影響.中華器官移植雜志,1988; 9(2)∶73. |
- 1. Lafferty KJ, Prowse SJ, Simeonovic CJ. Immunobiology of tissue transplantation: a return to the passenger leukocyte concept. Ann Rev Immunol, 1983; 1(1)∶143.
- 2. 羅江明.甲狀旁腺同種異體移植.中華器官移植雜志,1987; 8(1)∶45.
- 3. Faustman D, Hauptfeld V, Lacy PE, et al. Prolongation of murine islet allograft by pretreatment of islets with antibody directed to Ⅰa determinants. Proc Natl Acad Sci USA, 1981; 78(6)∶5156.
- 4. 羅江明,朱預(yù).高氧培養(yǎng)甲狀旁腺對(duì)大鼠同種移植腺體存活時(shí)間的影響.中華器官移植雜志,1988; 9(2)∶73.