• 1. 第三軍醫(yī)大學(xué)新橋醫(yī)院肝膽外科(重慶400037)2. 第一軍醫(yī)大學(xué)南方醫(yī)院肝膽外科;

通過(guò)犬膽道梗阻模型,動(dòng)態(tài)觀察了膽道梗阻后不同時(shí)相肝組織內(nèi)超氧化物歧化酶(SOD)及丙二醛(MDA)含量變化。結(jié)果發(fā)現(xiàn):犬膽道梗阻后2周其肝組織MDA含量較對(duì)照組明顯升高(P<0.01),梗阻后3周SOD含量亦有顯著下降(P<0.05),且二者變化隨著梗阻時(shí)間的延長(zhǎng)而加重。表明膽道梗阻后肝臟對(duì)自由基的清除能力下降,脂質(zhì)過(guò)氧化反應(yīng)增強(qiáng),可能是膽道梗阻導(dǎo)致肝損傷的原因之一。

引用本文: 李靖,遲彥邦,方學(xué)軍. 犬膽道梗阻后肝臟超氧化物歧化酶及過(guò)氧化脂質(zhì)的變化. 中國(guó)普外基礎(chǔ)與臨床雜志, 1998, 5(3): 148-149. doi: 復(fù)制

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2. 遲彥邦,黃志強(qiáng),張建超等. 實(shí)驗(yàn)性膽道阻塞性黃膽對(duì)肝、腎、肺的損害. 重慶醫(yī)藥, 1983; 11(6)∶53.
3. 李友元,何福清.自由基反應(yīng)與肝損傷. 國(guó)外醫(yī)學(xué)生理病理科學(xué)與臨床分冊(cè),1991; 11(3)∶136.
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5. 程迅生,遲彥邦,祁佐元. 慢性膽道梗阻時(shí)肝臟血流量及微血管床的變化. 中華外科雜志, 1992;30 (12)∶ 751.
6. Parks DA. Oxygen radicals∶mediators of gastrointestinal pathophysiology. Gut, 1989; 30(3)∶293.
7. Slater IF. Free radical mechanisms in tissue injury. Biochem J, 1984; 222(1)∶1.
  1. 1. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 1979; 95(2)∶351.
  2. 2. 遲彥邦,黃志強(qiáng),張建超等. 實(shí)驗(yàn)性膽道阻塞性黃膽對(duì)肝、腎、肺的損害. 重慶醫(yī)藥, 1983; 11(6)∶53.
  3. 3. 李友元,何福清.自由基反應(yīng)與肝損傷. 國(guó)外醫(yī)學(xué)生理病理科學(xué)與臨床分冊(cè),1991; 11(3)∶136.
  4. 4. Tsai LY, Lee KT, Tsai SM, et al. Changes of lipid peroxide levels in blood and liver tissue of patients with obstructive jaundice. Chinica Chimica Acta, 1993; 215(1)∶41.
  5. 5. 程迅生,遲彥邦,祁佐元. 慢性膽道梗阻時(shí)肝臟血流量及微血管床的變化. 中華外科雜志, 1992;30 (12)∶ 751.
  6. 6. Parks DA. Oxygen radicals∶mediators of gastrointestinal pathophysiology. Gut, 1989; 30(3)∶293.
  7. 7. Slater IF. Free radical mechanisms in tissue injury. Biochem J, 1984; 222(1)∶1.