用裸小鼠胃癌細胞移植瘤作為體內誘導分化研究模型，采用移植瘤生長狀態(tài)、移植瘤組織學、超微結構、細胞周期動力學變化及移植瘤p53、p21蛋白表達作為指標，研究了不同劑量的全反式維甲酸(ATRA)對裸小鼠胃癌細胞移植瘤的抗增殖及誘導分化作用。結果發(fā)現：在ATRA 300～1 000μg/只·d的劑量下，對移植瘤具有明顯生長抑制作用，并對移植瘤細胞有較強的誘導分化作用；同時可抑制移植瘤癌細胞p53、p21的表達。本實驗結果提示：ATRA在體內對人胃癌細胞有較強的抗增殖和誘導分化作用，這種抗癌作用可能與ATRA抑制癌細胞p53及p21表達，促進癌細胞凋亡有密切關系。
引用本文： 黃承良,王代科,劉寶華. 全反式維甲酸對人胃癌裸小鼠移植瘤的抗增殖及誘導分化作用. 中國普外基礎與臨床雜志, 1998, 5(3): 129-131. doi: 復制
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- 6. Skashita A, Ress J, Kadin M, et al. 9cis retinoic acid: effects on normal and leukemia hepatopoiesis in vitro. Blood, 1996; 81(5)∶1009.
- 7. Gwyn T, Saurit G, Moria C, et al. Molecular regulation of apoptosis: genetic controls on cell death. Cell, 1993; 74(6)∶777.
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