為探討肝細胞肝癌發(fā)生過程中bcl-2蛋白的變化規(guī)律及與細胞凋亡變化的關(guān)系，運用TUNEL法和免疫組化方法檢測石蠟保存的肝細胞肝癌組織(hepatocellular carcinoma, HCC)、肝硬變組織(liver cirrhosis,LC)和正常肝組織(normal liver, NL)中細胞凋亡發(fā)生率和bcl-2的表達。結(jié)果： 從NL、LC到HCC組織，細胞凋亡活性出現(xiàn)增強； bcl-2蛋白的表達逐漸下降，LC和HCC組比較，Ｐ＜0.05。結(jié)論： bcl-2的表達可能與肝細胞凋亡的抑制有關(guān)；在肝癌發(fā)生過程中，bcl-2表達下降可能是引起肝癌細胞凋亡增加的原因之一。
引用本文： 劉戰(zhàn)培,嚴律南. bcl-2蛋白在肝細胞肝癌發(fā)生過程中的表達及其與肝細胞凋亡變化的關(guān)系. 中國普外基礎(chǔ)與臨床雜志, 1999, 6(4): 193-195. doi: 復(fù)制
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