• 南京軍區(qū)南京總醫(yī)院(南京210002);

為觀察腹腔感染(IAI)致多系統(tǒng)器官功能障礙(MSOD)早期血漿內(nèi)毒素和細(xì)胞因子的變化，在制作IAI致MSOD動物模型的基礎(chǔ)上，對感染組(行盲腸結(jié)扎加穿孔手術(shù))及對照組(行盲腸探查術(shù))兔在實(shí)驗(yàn)0、1、2、3、4、5、6及24小時(shí)不同時(shí)相的血漿內(nèi)毒素和細(xì)胞因子包括腫瘤壞死因子(TNF)、白細(xì)胞介素1和6(IL-1，IL-6)進(jìn)行了檢測，并記錄動物死亡情況和生存時(shí)間。結(jié)果顯示：感染組血漿內(nèi)毒素和TNF水平在實(shí)驗(yàn)后1小時(shí)、IL-6在實(shí)驗(yàn)后2小時(shí)開始顯著升高，IL-1無顯著變化。感染組兔于1周內(nèi)均死亡，平均生存時(shí)間為84.1±39.0小時(shí)，對照組兔1周時(shí)均存活，兩組比較有顯著性差異(Ｐ＜0.05)。本實(shí)驗(yàn)所觀測到的IAI時(shí)血漿內(nèi)毒素及細(xì)胞因子的早期變化特點(diǎn)為臨床防治研究提供了實(shí)驗(yàn)基礎(chǔ)。

引用本文： 全竹富,黎介壽,臧靜,邵海楓,李珍大. 血漿內(nèi)毒素和細(xì)胞因子在腹腔感染致多系統(tǒng)器官功能障礙早期的變化. 中國普外基礎(chǔ)與臨床雜志, 1999, 6(2): 73-75. doi: 復(fù)制

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  2. 2. 全竹富， 黎介壽. 腹腔感染致多器官功能衰竭的動物模型. 中華實(shí)驗(yàn)外科雜志， 1991； 8(2)∶91.
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  4. 4. Creasey AA, Stevens P, Kenney J, et al. Endotoxin and cytokine profile in plasma of baboons challenged with lethal and sublethal E. Coli. Circ Shock, 1991; 33(2)∶84.
  5. 5. Spinas GA, Bloesch D, Keller LL, et al. Pretreatment with ibuprofen augemnts criculating TNFα, IL6, and elastase during acute endotoxaemia. J Infect Dis, 1991; 163(1)∶89.
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