目的 探討p16、Rb蛋白在甲狀腺癌發(fā)生、發(fā)展中的作用及其相互關(guān)系。方法 采用免疫組織化學(xué)SP法對(duì)46例甲狀腺癌中p16、Rb蛋白表達(dá)情況進(jìn)行檢測(cè)。結(jié)果 在甲狀腺癌中,p16蛋白的表達(dá)隨腫瘤的惡性程度增高而降低,與淋巴結(jié)轉(zhuǎn)移、臨床分期及預(yù)后指數(shù)呈負(fù)相關(guān)。Rb蛋白在各型甲狀腺癌中均呈陽性表達(dá),p16、Rb表達(dá)無相關(guān)性。結(jié)論 p16基因的異常表達(dá)在甲狀腺癌的發(fā)生、發(fā)展中有一定作用,而Rb基因可能無作用。
引用本文: 王子良,王農(nóng),耿建利,戰(zhàn)智勇,王太澤. 抑癌基因p16、Rb在甲狀腺癌組織中的表達(dá). 中國普外基礎(chǔ)與臨床雜志, 2001, 8(5): 319-321. doi: 復(fù)制
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