• 第三軍醫(yī)大學(xué)大坪醫(yī)院野戰(zhàn)外科研究所普外科(重慶 400042);

目的  介紹端粒、端粒酶的性質(zhì)及其與腫瘤的關(guān)系，了解端粒、端粒酶在胃癌中的表達(dá)及意義。
方法 綜述國(guó)內(nèi)外進(jìn)展。
結(jié)果  端粒酶活性在85%～90%的胃癌中可以檢測(cè)到，在表達(dá)端粒酶陽性的患者比表達(dá)陰性的患者預(yù)后要差，表明端粒酶陽性的胃癌惡性程度更高。
結(jié)論  胃癌端粒酶活性檢測(cè)不僅可用于診斷，且可用于表示預(yù)后，未來用于抑制端粒酶的藥物可以提供一種副作用較少的治療癌癥的方法。

引用本文： 王亞旭 綜述 王代科審校. 胃腫瘤端粒酶的研究近況. 中國(guó)普外基礎(chǔ)與臨床雜志, 2001, 8(1): 56-58. doi: 復(fù)制

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2. Yu GL, Bradley JD, Attardi LD, et al.In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs [J]. Nature, 1990; 344(6262)∶126.
3. Maruyama Y, Hanei H, Fujita M, et al.Telomere length and telomerase activity in carcinogenesis of the stomach [J]. Nippon Rinsho, 1998; 56(5)∶1186.
4. Hiyama E, Hiyama K, Yokoyama T, et al.Correlating telomerase activity levels with human neuroblastoma outcomes [J]. Nat Med, 1995; 1(3)∶249.
5. Hiyama K, Hiyama E, Ishioka S, et al.Telomerase activity in smallcell and nonsmallcell lung cancers [J]. N Natl Cancer Inst, 1995; 87(12)∶895.
6. Chadeneau C, Hay K, Hirte HVV, et al.Telomerase activity associated with acquisition of malignancy in human colorectal cancer[J]. Cancer Res, 1995; 55(12)∶2533.
7. Tahara H, Nakanishi T, Kitamoto M, et al.Telomerase activity in human liver tissues:comparison between chronic liver disease and hepotocellular carcinomas [J].Cancer Res, 1995; 55(13)∶2734.
8. Hiyama E, Yokoyama T, Tatsumoto N, et al.Telomerase activity in gastric cancer [J]. Cancer Res, 1995; 55(15)∶3258.
9. Hiyama E, Gollahon L, Kataoka T, et al.Telomerase activity for the preoperative diagnosis of pancreatic cancer [J]. J Natl Cancer Inst, 1996; 88(2)∶116.
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14. Ahn MJ, Nph YH, Lee YS, et al.Telomerase activity and its clinicopathological significance in gastric cancer [J]. Eur J Cancer, 1997; 33(8)∶1309.
15. Tahara E, Semba S, Tahara H. Molecular biological observationa in gastric cancer [J]. Semin Oncol, 1996; 23(3)∶307.
16. Kuniyasu H, Domen T, Hamamoto T, et al.Expression of human telomerase RNA is an early event of stomach carcinogenesis [J]. Jpn J Cancer Res, 1997; 88(2)∶103.
17. Okusa Y, Shinomiya N, Ichikura T, et al.Correlation between telomerase activity and DNA ploicly in gastric cancer [J]. Oncology, 1998; 55(3)∶258.
18. Ogawa K, Wakasugi S, Katsube T, et al.Relationship between telomerase activity and clinicopathological findings in gastric cancer [J]. 1998; 56(5)∶1194.
19. 衛(wèi)建平，王晨，王晶晶等.端粒酶HTR在癌及癌前病變中表達(dá)的意義探討 [J].山西醫(yī)藥雜志，1998； 27(3)∶196.
20. Ichikura T, Okusa Y, Mochizuki H. Telomerase activity during the cell cycle in gastric cancer cell lines [J]. Nippon Rinsho, 1998; 56(5)∶1199.
  1. 1. Kim NW, Platyszek MA, Prowse KR, et al.Specific association of human teloymerase activity with immortal cells and cancer [J].Science, 1994; 266(5193)∶2011.
  2. 2. Yu GL, Bradley JD, Attardi LD, et al.In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs [J]. Nature, 1990; 344(6262)∶126.
  3. 3. Maruyama Y, Hanei H, Fujita M, et al.Telomere length and telomerase activity in carcinogenesis of the stomach [J]. Nippon Rinsho, 1998; 56(5)∶1186.
  4. 4. Hiyama E, Hiyama K, Yokoyama T, et al.Correlating telomerase activity levels with human neuroblastoma outcomes [J]. Nat Med, 1995; 1(3)∶249.
  5. 5. Hiyama K, Hiyama E, Ishioka S, et al.Telomerase activity in smallcell and nonsmallcell lung cancers [J]. N Natl Cancer Inst, 1995; 87(12)∶895.
  6. 6. Chadeneau C, Hay K, Hirte HVV, et al.Telomerase activity associated with acquisition of malignancy in human colorectal cancer[J]. Cancer Res, 1995; 55(12)∶2533.
  7. 7. Tahara H, Nakanishi T, Kitamoto M, et al.Telomerase activity in human liver tissues:comparison between chronic liver disease and hepotocellular carcinomas [J].Cancer Res, 1995; 55(13)∶2734.
  8. 8. Hiyama E, Yokoyama T, Tatsumoto N, et al.Telomerase activity in gastric cancer [J]. Cancer Res, 1995; 55(15)∶3258.
  9. 9. Hiyama E, Gollahon L, Kataoka T, et al.Telomerase activity for the preoperative diagnosis of pancreatic cancer [J]. J Natl Cancer Inst, 1996; 88(2)∶116.
  10. 10. Iwao T, Hiyama E, Yokoyama T, et al.Telomerase activity for the preoperative diagnosis of pancreatic cancer [J]. J Natl Cancer Inst, 1997; 89(21)∶1121.
  11. 11. Wright PA, Williams GT. Molecular biology and gastric carcinoma [J]. Gut, 1993; 34(2)∶145.
  12. 12. 楊仕明，房殿春，羅之輝等.胃癌及癌前組織中端粒酶活性的檢測(cè)及臨床意義 [J].中華醫(yī)學(xué)雜志，1998； 78(3)∶207.
  13. 13. 楊仕明，房殿春，羅之輝等.胃癌組織中端粒酶活性的檢測(cè)及臨床意義 [J].第三軍醫(yī)大學(xué)學(xué)報(bào)，1997； 19(5)∶401.
  14. 14. Ahn MJ, Nph YH, Lee YS, et al.Telomerase activity and its clinicopathological significance in gastric cancer [J]. Eur J Cancer, 1997; 33(8)∶1309.
  15. 15. Tahara E, Semba S, Tahara H. Molecular biological observationa in gastric cancer [J]. Semin Oncol, 1996; 23(3)∶307.
  16. 16. Kuniyasu H, Domen T, Hamamoto T, et al.Expression of human telomerase RNA is an early event of stomach carcinogenesis [J]. Jpn J Cancer Res, 1997; 88(2)∶103.
  17. 17. Okusa Y, Shinomiya N, Ichikura T, et al.Correlation between telomerase activity and DNA ploicly in gastric cancer [J]. Oncology, 1998; 55(3)∶258.
  18. 18. Ogawa K, Wakasugi S, Katsube T, et al.Relationship between telomerase activity and clinicopathological findings in gastric cancer [J]. 1998; 56(5)∶1194.
  19. 19. 衛(wèi)建平，王晨，王晶晶等.端粒酶HTR在癌及癌前病變中表達(dá)的意義探討 [J].山西醫(yī)藥雜志，1998； 27(3)∶196.
  20. 20. Ichikura T, Okusa Y, Mochizuki H. Telomerase activity during the cell cycle in gastric cancer cell lines [J]. Nippon Rinsho, 1998; 56(5)∶1199.