腫瘤細胞的多藥耐藥性的產(chǎn)生與P糖蛋白(PgP)及谷胱甘肽轉移酶(GST)等的過度表達有密切關系。為進一步了解胃和食管惡性腫瘤細胞的耐藥機理,為化療中克服耐藥,制定合理、高效的化療方案提供依據(jù)。
引用本文: 薛軍,支學軍,屈明,楊東東,薄愛華. 胃癌及食管癌中腫瘤耐藥標志物P-糖蛋白和谷胱甘肽轉移酶表達的研究. 中國普外基礎與臨床雜志, 2002, 9(5): 1-01. doi: 復制
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- 2. 吳名耀,沈健,吳賢英. P糖蛋白在食管癌中的表達及其臨床意義 [J].臨床及實驗病理學雜志,1997; 13(20)∶192.
- 3. Tsuchida S, Sekine Y, Shineha R, et al. Elevation of the placental glutathione Stransferase form (GSTpi) in tumor tissues and the levels in sera of patients with cancer [J].Cancer Res, 1989; 49(18)∶5225.
- 4. Hamada S, Kamada M, Furumoto H, et al. Expression of glutathione Stransferasepi in human ovarian cancer as an indictor of resistance to chemotherapy [J].Gynecol Oncol, 1994; 52(3)∶313.