• 四川大學(xué)華西醫(yī)院普外科（成都610041);

目的探討抗腫瘤新生血管形成治療實體腫瘤的可行性。方法對近5年的國內(nèi)、外有關(guān)文獻(xiàn)進(jìn)行綜述。結(jié)果實體腫瘤的生長、發(fā)展、轉(zhuǎn)移及預(yù)后好壞均與腫瘤新生血管形成密切相關(guān)。體外及動物實驗表明，抑制、阻斷腫瘤新生血管形成后可以抑制腫瘤的生長及轉(zhuǎn)移。結(jié)論抗腫瘤新生血管形成將成為治療實體腫瘤的一個有希望的新策略。

引用本文： 李宏江,綜述,趙揚冰,審校. 抗腫瘤新生血管形成治療實體腫瘤的研究進(jìn)展. 中國普外基礎(chǔ)與臨床雜志, 2002, 9(3): 207-209. doi: 復(fù)制

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2. Folkman J. Diagnostic and therapeutic applications of angiogenesis research [Ｊ]. C R Acad Sci Paris Ⅲ, 1993; 316(9)∶914.
3. Battegay EJ. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects [Ｊ]. J Mol Med, 1995; 73(7)∶333.
4. 董為人，彭必友，李進(jìn)，等. 細(xì)胞粘附與血管生成 [Ｊ].國外醫(yī)學(xué)外科學(xué)分冊，1998； 25（1）∶29.
5. Guinebretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease [Ｊ]. J Natl Cancer Inst, 1994; 86(8)∶635.
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7. 李宏江，趙揚冰，張世羽，等. 微血管檢測對乳腺癌患者預(yù)后的預(yù)示價值 [Ｊ]. 中華實驗外科雜志，1999； 16（增）∶49.
8. Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastasis of biopsy material in rabbit thyroid and canine intestinal segment [Ｊ]. Ann Surg, 1966; 164(3)∶491.
9. Brooks PC, Stromblad S, Klemke R, et al. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin [Ｊ]. J Clin Invest, 1995; 96(4)∶1815.
10. Im SA, GomezManzano C, Fueyo J, et al. Antiangiogenesis treatment for gliomas: transfer of antisensevascular endothelial growth factor inhibits tumor growth in vivo [Ｊ]. Cancer Res, 1999; 59(4)∶895.
11. 章翔，吳景文，高大寬，等. 血管內(nèi)皮生長因子165反義RNA治療人腦膠質(zhì)瘤的實驗研究 [Ｊ].中華醫(yī)學(xué)雜志，2000； 80（5）∶386.
12. Borgstrom P, Bourdon MA, Hillan KJ, et al. Neutralizing antivascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo [Ｊ]. Prostate, 1998; 35(1)∶1.
13. Goldman CK, Kendall RL, Cabrera G, et al. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8795.
14. Lin P, Buxton JA, Acheson A, et al. Antiangiogenic gene therapy targeting the endotheliumspecific receptor tyrosine kinase Tie2[Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8829.
15. 宋述梅，壽成超. 原核表達(dá)的可溶性血管內(nèi)皮生長因子受體對血管內(nèi)皮生長因子活性的抑制 [Ｊ].中華醫(yī)學(xué)雜志， 2000； 80（3）∶226.
16. Lin H, Lu H, Griscelli F, et al. Adenovirusmediated delivery of a uPA/uPAR antagonist suppresses angiogenesisdependent tumor growth and dissemination in mice [Ｊ]. Gene Ther, 1998; 5(8)∶1105.
17. Griscelli F, Li H, BennaceurGriscelli A, et al. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(11)∶6367.
18. Valente P, Fassina G, Melchiori A, et al. TIMP2 overexpression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis [Ｊ]. Int J Cancer, 1998; 75(2)∶246.
19. Zabrenetzky V, Harris CC, Steeg PS, et al. Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines [Ｊ]. Int J Cancer, 1994; 59(2)∶191.
20. Zajchowcki DA, Band V, Trask DK, et al. Suppression of tumorforming ability and related traits in MCF7 human breast cancer cells by fusion with immortal mammary epithelial cells [Ｊ]. Proc Natl Acad Sci USA, 1990; 87(6)∶2314.
21. 郭文忠， 楊治華，劉軍，等. 血管形成抑制因子HIAF1的克隆及其抗腫瘤作用 [Ｊ]. 中華腫瘤雜志， 2000； 22（1）∶19.
22. Singh Y, Shikata N, Kiyozuka Y, et al. Inhibition of tumor growth and metastasis by angiogenesis inhibitor TNP470 on breast cancer cell lines in vitro and in vivo [Ｊ]. Breast Cancer Res Treat, 1997; 45(1)∶15.
23. 夏景林，任正剛，楊秉輝，等. 血管形成抑制劑TNP470對肝癌組織VEGF表達(dá)的影響 [Ｊ]. 中華腫瘤雜志，2000； 22（1）∶26.
  1. 1. Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis: a new significant and independent prognostic indicator in earlystage breast carcinoma [Ｊ]. J Natl Cancer Inst, 1992; 84(24)∶1875.
  2. 2. Folkman J. Diagnostic and therapeutic applications of angiogenesis research [Ｊ]. C R Acad Sci Paris Ⅲ, 1993; 316(9)∶914.
  3. 3. Battegay EJ. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects [Ｊ]. J Mol Med, 1995; 73(7)∶333.
  4. 4. 董為人，彭必友，李進(jìn)，等. 細(xì)胞粘附與血管生成 [Ｊ].國外醫(yī)學(xué)外科學(xué)分冊，1998； 25（1）∶29.
  5. 5. Guinebretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease [Ｊ]. J Natl Cancer Inst, 1994; 86(8)∶635.
  6. 6. 李宏江，敬靜，朱精強(qiáng)，等. 乳腺疾病中微血管的觀察分析 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志，1999； 6（5）∶285.
  7. 7. 李宏江，趙揚冰，張世羽，等. 微血管檢測對乳腺癌患者預(yù)后的預(yù)示價值 [Ｊ]. 中華實驗外科雜志，1999； 16（增）∶49.
  8. 8. Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastasis of biopsy material in rabbit thyroid and canine intestinal segment [Ｊ]. Ann Surg, 1966; 164(3)∶491.
  9. 9. Brooks PC, Stromblad S, Klemke R, et al. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin [Ｊ]. J Clin Invest, 1995; 96(4)∶1815.
  10. 10. Im SA, GomezManzano C, Fueyo J, et al. Antiangiogenesis treatment for gliomas: transfer of antisensevascular endothelial growth factor inhibits tumor growth in vivo [Ｊ]. Cancer Res, 1999; 59(4)∶895.
  11. 11. 章翔，吳景文，高大寬，等. 血管內(nèi)皮生長因子165反義RNA治療人腦膠質(zhì)瘤的實驗研究 [Ｊ].中華醫(yī)學(xué)雜志，2000； 80（5）∶386.
  12. 12. Borgstrom P, Bourdon MA, Hillan KJ, et al. Neutralizing antivascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo [Ｊ]. Prostate, 1998; 35(1)∶1.
  13. 13. Goldman CK, Kendall RL, Cabrera G, et al. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8795.
  14. 14. Lin P, Buxton JA, Acheson A, et al. Antiangiogenic gene therapy targeting the endotheliumspecific receptor tyrosine kinase Tie2[Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8829.
  15. 15. 宋述梅，壽成超. 原核表達(dá)的可溶性血管內(nèi)皮生長因子受體對血管內(nèi)皮生長因子活性的抑制 [Ｊ].中華醫(yī)學(xué)雜志， 2000； 80（3）∶226.
  16. 16. Lin H, Lu H, Griscelli F, et al. Adenovirusmediated delivery of a uPA/uPAR antagonist suppresses angiogenesisdependent tumor growth and dissemination in mice [Ｊ]. Gene Ther, 1998; 5(8)∶1105.
  17. 17. Griscelli F, Li H, BennaceurGriscelli A, et al. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(11)∶6367.
  18. 18. Valente P, Fassina G, Melchiori A, et al. TIMP2 overexpression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis [Ｊ]. Int J Cancer, 1998; 75(2)∶246.
  19. 19. Zabrenetzky V, Harris CC, Steeg PS, et al. Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines [Ｊ]. Int J Cancer, 1994; 59(2)∶191.
  20. 20. Zajchowcki DA, Band V, Trask DK, et al. Suppression of tumorforming ability and related traits in MCF7 human breast cancer cells by fusion with immortal mammary epithelial cells [Ｊ]. Proc Natl Acad Sci USA, 1990; 87(6)∶2314.
  21. 21. 郭文忠， 楊治華，劉軍，等. 血管形成抑制因子HIAF1的克隆及其抗腫瘤作用 [Ｊ]. 中華腫瘤雜志， 2000； 22（1）∶19.
  22. 22. Singh Y, Shikata N, Kiyozuka Y, et al. Inhibition of tumor growth and metastasis by angiogenesis inhibitor TNP470 on breast cancer cell lines in vitro and in vivo [Ｊ]. Breast Cancer Res Treat, 1997; 45(1)∶15.
  23. 23. 夏景林，任正剛，楊秉輝，等. 血管形成抑制劑TNP470對肝癌組織VEGF表達(dá)的影響 [Ｊ]. 中華腫瘤雜志，2000； 22（1）∶26.