目的探討胃癌的生物學特性及與臨床之間的關系。方法對1034例各期、各個部位的胃癌的臨床及病理資料進行回顧性分析。結(jié)果早期胃癌148例,占總數(shù)的14.3%; 胃體和胃底部的胃癌淋巴結(jié)轉(zhuǎn)移率明顯高于其它部位的胃癌(P<0.0001); 腫瘤直徑大的胃癌分化差(P=0.004)、浸潤深(P<0.0001),淋巴結(jié)轉(zhuǎn)移率也較高(P<0.01)。浸潤深度較深的胃癌患者平均年齡大于浸潤深度較淺的患者(P=0.003),分化差的患者平均年齡低于分化好的患者(P<0.0001)。女性患者的腫瘤相當一部分位于胃的近端,男性則以位于胃的遠端為多見(P<0.001); 女性患者腫瘤分化差的比例高于男性(P<0.001),淋巴結(jié)轉(zhuǎn)移率 gt;30%以上者也比男性高(P=0.01)。多因素線性多元回歸分析發(fā)現(xiàn),腫瘤部位(P=0.003)、直徑(P<0.0001)、浸潤深度(P<0.0001)及分化程度(P<0.001)與淋巴結(jié)轉(zhuǎn)移密切相關,女性患者較男性更易發(fā)生淋巴結(jié)轉(zhuǎn)移(P<0.001),其中決定淋巴結(jié)轉(zhuǎn)移最重要的因素是腫瘤浸潤胃壁的深度。全胃切除術清掃的淋巴結(jié)數(shù)最多,其次為遠端胃大部切除術; 術后并發(fā)癥發(fā)生率最高的手術是經(jīng)腹近端胃大部切除術(17%)。結(jié)論為降低術后復發(fā),對各期胃癌手術時均應進行淋巴結(jié)的清掃。
引用本文: 牛偉新逄兵秦新裕王承培. 1034例胃癌的臨床及病理學分析. 中國普外基礎與臨床雜志, 2002, 9(3): 145-147. doi: 復制
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