目的 探討唾液酸化路易斯X(sialyl LewisX,SLeX)抗原和CD44v6表達與膽管癌生物學行為的關系。方法用催化信號放大(catalyzed signal amplification,CSA)免疫組化方法,檢測43例膽管癌組織及10例慢性膽管炎組織中SLeX抗原和CD44v6蛋白的表達,分析SLeX和CD44v6蛋白的表達與膽管癌臨床病理特征的關系。結果在膽管癌組織中,SLeX和CD44v6表達陽性率分別為67.4%和62.8%,顯著高于對照組的20.0%(P<0.05)。SLeX和CD44v6表達陽性率與膽管癌的TNM分期、分化程度、淋巴結和臟器轉(zhuǎn)移密切相關(P<0.05)。SLeX表達與CD44v6表達呈正相關(r=0.49,P<0.001)。結論檢測SLeX和CD44v6的基因表達可作為評估膽管癌生物學行為和預后的參考指標。
引用本文: 谷化平尚培中劉艷茹. 唾液酸化路易斯-X抗原和CD44v6表達與膽管癌生物學行為的關系. 中國普外基礎與臨床雜志, 2003, 10(5): 442-444. doi: 復制
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