目的 探討粘蛋白(MUC1,MUC3)在結(jié)石性膽囊炎和膽囊腺瘤樣息肉中的表達(dá)規(guī)律。方法采用免疫組化AEC法和蛋白印跡雜交（Western blot）方法對20例正常膽囊標(biāo)本（對照組），38例結(jié)石性膽囊炎（結(jié)石組）及18例膽囊腺瘤樣息肉（息肉組）的膽囊粘膜中MUC1、MUC3的表達(dá)進(jìn)行檢測。結(jié)果免疫組化檢測與蛋白印跡雜交分析結(jié)果均顯示，結(jié)石組及息肉組MUC1的表達(dá)陽性率明顯高于對照組（P＜0.01），而MUC3的表達(dá)陽性率則明顯低于對照組（P＜0.01）； 結(jié)石組MUC3的表達(dá)陽性率又明顯高于息肉組（P＜0.01）。結(jié)論MUC1和MUC3在結(jié)石性膽囊炎及膽囊腺瘤樣息肉中的表達(dá)呈負(fù)相關(guān)，這可能與結(jié)石形成及膽囊癌前病變有關(guān)。
引用本文： 曹紅,陳東風(fēng),鄭偉. MUC1、MUC3在結(jié)石性膽囊炎和膽囊腺瘤樣息肉粘膜組織中的表達(dá)及其意義. 中國普外基礎(chǔ)與臨床雜志, 2003, 10(4): 379-382. doi: 復(fù)制
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- 5. BiemerHuttmann AE, Walsh MD, McGuckin MA, et al. Immunohistochemical staining patterns of MUC1, MUC2, MUC4 and MUC5 AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum [J]. J Histochem Cytochem, 1999; 47(8)∶1039.
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- 7. Yamato T, Kurumaya H, Ohama K, et al. Frequent expression of mucin core protein MUC1 in nonneoplastic gallbladder mucosa from patients with pancreaticobiliary maljunction [J]. Liver, 1999; 19(4)∶281.
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