目的探討阻塞性黃疸患者并發(fā)腎功能損害時(shí)血清一氧化氮（NO）的變化及其臨床意義。方法對25例阻塞性黃疸并發(fā)腎功能損害患者的血清NO、一氧化氮合成酶（NOS）活性、BUN和Cr值進(jìn)行檢測，并以26例健康者作為正常對照。結(jié)果阻塞性黃疸組BUN和Cr高于正常對照組（P＜0.01），而NO和NOS則低于正常對照組（P＜0.01）。相關(guān)分析顯示，NO與BUN和Cr呈負(fù)相關(guān)關(guān)系，其相關(guān)系數(shù)分別為-0.419和-0.553（P＜0.01）。結(jié)論阻塞性黃疸并發(fā)腎功能損害時(shí)其血清NO和NOS下降，提示NO在阻塞性黃疸時(shí)對腎功能有一定保護(hù)作用。
引用本文： 王華,李智宇,張小文,李越華,李立春,王炳煌. 阻塞性黃疸患者并發(fā)腎功能損害時(shí)血清一氧化氮的變化及其臨床意義. 中國普外基礎(chǔ)與臨床雜志, 2003, 10(1): 41-42. doi: 復(fù)制
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- 1. Fogarty BJ, Parks RW, Rowlands BJ，et al. Renal dysfunction in obstructive jaundice [J]. Br J Surg, 1995; 82（7）∶ 877.
- 2. 李智宇，張炳彥，王炳煌,等. 一氧化氮對急性膽道感染大鼠腎功能影響作用研究 [J]. 中國普外基礎(chǔ)與臨床雜志， 2001； 8（2）∶69.
- 3. Endlich K， Muller C, Barthelmebs M， et al. Role of shear stress in nitric oxidedependent modulation of renal angiotensin Ⅱ vasoconstriction [J]. Br J Pharmacol, 1999; 127(8)∶1929.
- 4. Olszanecki R, Chlopicki S.Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia [J]. J Physiol Pharmacol, 1999; 50(3)∶443.
- 5. Fierro IM,NascimentoDaSilva V, Arruda MA, et al. Induction of NOS in rat blood PMN in vivo and in vitro: modulation by tyrosine kinase and involvement in bactericidal activity [J]. J Leukoc Biol, 1999; 65(4)∶508.
- 6. Cowley AW,Roman RJ,Fenoy FJ,et al.Effect of renal medullary circulation on arterial pressure [J].J Hypertens Suppl, 1992; 10(7)∶S187.
- 7. Goligorsky MS, Noiri E. Duality of nitric oxide in acute renal injury [J]. Semin Nephrol, 1999; 19(3)∶263.
- 8. Schwartz D, Blantz RC. Nitric oxide, sepsis,and the kidney [J]. Semin Nephrol, 1999; 19(3)∶272.