• 1.四川大學(xué)華西醫(yī)院普外科（成都610041）;;
  • 2.黑龍江省訥河市第一人民醫(yī)院（訥河161300）;

目的探討胃起搏在術(shù)后胃輕癱治療中的可行性及療效。方法在術(shù)后急性胃輕癱動(dòng)物模型的基礎(chǔ)上分別應(yīng)用胃起搏和靜脈注射紅霉素（1 mg/kg），觀察胃動(dòng)力學(xué)指標(biāo)的改變。結(jié)果胃起搏組和紅霉素組胃竇壓及胃竇十二指腸壓力差均顯著高于對(duì)照組基礎(chǔ)壓（P＜0.01）； 胃起搏組胃竇壓及胃竇十二指腸壓力差又高于紅霉素組（P＜0.05），但兩組十二指腸內(nèi)壓差異無(wú)顯著性意義(P gt;0.05)。胃起搏2 h的胃排空率為(66.37±7.21)% ，高于靜脈注射紅霉素2 h的胃排空率〔(49.92±9.27)%，P＜0.01〕。結(jié)論高頻胃起搏能明顯改善胃動(dòng)力學(xué)指標(biāo)，可用于術(shù)后胃輕癱的治療，且療效優(yōu)于紅霉素。

引用本文： 李富宇 ,何生,于運(yùn)海,毛輝. 胃起搏對(duì)術(shù)后胃動(dòng)力影響的實(shí)驗(yàn)研究. 中國(guó)普外基礎(chǔ)與臨床雜志, 2003, 10(1): 33-35. doi: 復(fù)制

1. Mintchev MP, Sanmiguel CP, Otto SJ, et al. Microprocessor controlled movement of liquid gastric content using sequential neural electrical stimulation [Ｊ]. Gut, 1998; 43(5)∶607.
2. 陳思維，薛淑英，王敏華，等. 介紹一種簡(jiǎn)易實(shí)驗(yàn)性胃排空測(cè)定方法 [Ｊ].中醫(yī)藥理學(xué)通報(bào)， 1994； 5（2）∶317.
3. Kim CH, Malagelada JR. Electrical activity of the stomach: clinical implications [Ｊ]. Mayo Clin Proc， 1986; 61(3)∶205.
4. Kelly KA. Gastric motility and ulcer surgery [Ｊ]. Surg Clin North Am, 1971； 51(4 )∶927.
5. Stoddard CJ, Smallwood RH, Duthie HL. Electrical arrhythmias in human stomach [Ｊ]. Gut, 1981； 22（9）∶705.
6. Kim CH, Azpiroz F, Malagelada JR. Characteristics of spontaneous and druginduced gastric dysrhythmias in a chronic canine model [Ｊ].Gastroenterology, 1986; 90(2)∶421.
7. Familoni BO，Abell TL, Nemoto D, et al.Efficacy of electrical stimulation at frequencies higher than basal rate in canine stomach [Ｊ].Dig Dis Sci, 1997； 42（5）∶892.
8. Yokota M, Ando N, Ozawa S,et al. Enhanced motility of the vagotomized canine stomach by electrical stimulation [Ｊ]. J Gastroenterol Hepatol, 1997； 12（4）∶ 338.
9. GEMS study groups. Report of multicenter study on electrical stimulation for the treatment of gastroparesis [Ｊ].Motili NerveGut Interact, 1997; 4（2）∶A736.
10. McCallum RW, Chen JD, Lin Z, et al.Gastric pacing improves emptying and symptoms in patients with gastroparesis [Ｊ]. Gastroenterology, 1998； 114（3）∶456.
11. Kelly KA. Pacing the gut [Ｊ]. Gastroenterology, 1992； 103（6）∶1967.
  1. 1. Mintchev MP, Sanmiguel CP, Otto SJ, et al. Microprocessor controlled movement of liquid gastric content using sequential neural electrical stimulation [Ｊ]. Gut, 1998; 43(5)∶607.
  2. 2. 陳思維，薛淑英，王敏華，等. 介紹一種簡(jiǎn)易實(shí)驗(yàn)性胃排空測(cè)定方法 [Ｊ].中醫(yī)藥理學(xué)通報(bào)， 1994； 5（2）∶317.
  3. 3. Kim CH, Malagelada JR. Electrical activity of the stomach: clinical implications [Ｊ]. Mayo Clin Proc， 1986; 61(3)∶205.
  4. 4. Kelly KA. Gastric motility and ulcer surgery [Ｊ]. Surg Clin North Am, 1971； 51(4 )∶927.
  5. 5. Stoddard CJ, Smallwood RH, Duthie HL. Electrical arrhythmias in human stomach [Ｊ]. Gut, 1981； 22（9）∶705.
  6. 6. Kim CH, Azpiroz F, Malagelada JR. Characteristics of spontaneous and druginduced gastric dysrhythmias in a chronic canine model [Ｊ].Gastroenterology, 1986; 90(2)∶421.
  7. 7. Familoni BO，Abell TL, Nemoto D, et al.Efficacy of electrical stimulation at frequencies higher than basal rate in canine stomach [Ｊ].Dig Dis Sci, 1997； 42（5）∶892.
  8. 8. Yokota M, Ando N, Ozawa S,et al. Enhanced motility of the vagotomized canine stomach by electrical stimulation [Ｊ]. J Gastroenterol Hepatol, 1997； 12（4）∶ 338.
  9. 9. GEMS study groups. Report of multicenter study on electrical stimulation for the treatment of gastroparesis [Ｊ].Motili NerveGut Interact, 1997; 4（2）∶A736.
  10. 10. McCallum RW, Chen JD, Lin Z, et al.Gastric pacing improves emptying and symptoms in patients with gastroparesis [Ｊ]. Gastroenterology, 1998； 114（3）∶456.
  11. 11. Kelly KA. Pacing the gut [Ｊ]. Gastroenterology, 1992； 103（6）∶1967.