• 四川大學(xué)華西醫(yī)院放射科（成都610041）;

目的  綜合評(píng)述CT灌注成像（CT perfusion imaging）的原理、技術(shù)要求及其在腹部影像診斷中的應(yīng)用價(jià)值。
方法  總結(jié)CT灌注成像的原理和技術(shù)要求，評(píng)價(jià)其在腹部疾?。ㄖ饕歉闻K、胰腺）應(yīng)用中所提供的組織器官微循環(huán)狀況、血流動(dòng)力學(xué)變化及其它參數(shù)。
結(jié)果  CT灌注成像評(píng)價(jià)肝臟、胰腺病變，尤其是腫瘤性病變，除了能顯示解剖形態(tài)學(xué)改變，還能了解血供情況、血流動(dòng)力學(xué)狀態(tài)等反映功能、代謝變化的信息，對(duì)腹部腫瘤性疾病的診斷有重要意義。
結(jié)論  CT灌注成像將在腹部疾病的影像診斷與鑒別診斷、腫瘤生物學(xué)行為和嚴(yán)重度評(píng)價(jià)、療效評(píng)估等方面發(fā)揮重要作用，具有較良好的臨床應(yīng)用前景。

引用本文： 宋彬. CT灌注成像的原理、技術(shù)及在腹部影像診斷中的應(yīng)用. 中國(guó)普外基礎(chǔ)與臨床雜志, 2004, 11(2): 171-174. doi: 復(fù)制

1. Miles KA. Measurement of tissue perfusion by dynamic computed tomography [J]. Br J Radiol, 1991; 64(761)∶409.
2. Miles KA, Hayball M, Dixon AK. Colour perfusion imaging: a new application of computed tomography [Ｊ]. Lancet, 1991; 337(8742)∶643.
3. Miles KA, Hayball MP, Dixon AK. Functional images of hepatic perfusion obtained with dynamic CT [Ｊ]. Radiology, 1993; 188(2)∶405.
4. Miles KA, Hayball MP, Dixon AK. Measurement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging [Ｊ]. Br J Radiol, 1995; 68(809)∶471.
5. Cenic A, Nabavi DG, Craen RA, et al. Dynamic CT measurement of cerebral blood flow: a validation study [Ｊ]. AJNR Am J Neuroradiol, 1999; 20(1)∶63.
6. Axel L. Cerebral blood flow determination by rapidsequence computed tomography: theoretical analysis [Ｊ]. Radiology, 1980; 137(3)∶679.
7. Eastwood JD, Lev MH, Azhari T, et al. CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke [Ｊ]. Radiology, 2002; 222(1)∶227.
8. Bell SD, Peters AM. Measurement of blood flow from firstpass radionuclide angiography: influence of bolus volume [Ｊ]. Eur J Nucl Med, 1991; 18(11)∶885.
9. Klotz E, Konig M. Perfusion measurements of the brain: using dynamic CT for the quantitative assessment of cerebral ischemia in acute stroke [Ｊ]. Eur J Radiol, 1999; 30(3)∶170.
10. Koenig M, Klotz E, Luka B, et al. Perfusion CT of the brain: diagnostic approach for early detection of ischemic stroke [Ｊ] Radiology, 1998; 209(1)∶85.
11. Miles KA. Tumour angiogenesis and its relation to contrast enhancement on computed tomography: a review [Ｊ]. Eur J Radiol, 1999; 30(3)∶198.
12. Dugdale PE, Miles KA, Bunce I, et al. CT measurement of perfusion and permeability within lymphoma masses and its ability to assess grade, activity, and chemotherapeutic response [Ｊ]. J Comput Assist Tomogr, 1999; 23(4)∶540.
13. Brix G, Bahner ML, Hoffmann U, et al. Regional blood flow, capillary permeability, and compartmental volumes: measurement with dynamic CTinitial experience [Ｊ]. Radiology, 1999; 210(1)∶269.
14. Miles KA, Leggett DA, Kelley BB, et al. In vivo assessment of neovascularization of liver metastases using perfusion CT [Ｊ]. Br J Radiol, 1998; 71(843)∶276.
15. Bader TR, Herneth AM, Blaicher W, et al. Hepatic perfusion after liver transplantation: noninvasive measurement with dynamic singlesection CT [Ｊ]. Radiology, 1998; 209(1)∶129.
16. Leggett DA, Kelley BB, Bunce IH, et al. Colorectal cancer: diagnostic potential of CT measurements of hepatic perfusion and implications for contrast enhancement protocols [Ｊ]. Radiology, 1997; 205(3)∶716.
  1. 1. Miles KA. Measurement of tissue perfusion by dynamic computed tomography [J]. Br J Radiol, 1991; 64(761)∶409.
  2. 2. Miles KA, Hayball M, Dixon AK. Colour perfusion imaging: a new application of computed tomography [Ｊ]. Lancet, 1991; 337(8742)∶643.
  3. 3. Miles KA, Hayball MP, Dixon AK. Functional images of hepatic perfusion obtained with dynamic CT [Ｊ]. Radiology, 1993; 188(2)∶405.
  4. 4. Miles KA, Hayball MP, Dixon AK. Measurement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging [Ｊ]. Br J Radiol, 1995; 68(809)∶471.
  5. 5. Cenic A, Nabavi DG, Craen RA, et al. Dynamic CT measurement of cerebral blood flow: a validation study [Ｊ]. AJNR Am J Neuroradiol, 1999; 20(1)∶63.
  6. 6. Axel L. Cerebral blood flow determination by rapidsequence computed tomography: theoretical analysis [Ｊ]. Radiology, 1980; 137(3)∶679.
  7. 7. Eastwood JD, Lev MH, Azhari T, et al. CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke [Ｊ]. Radiology, 2002; 222(1)∶227.
  8. 8. Bell SD, Peters AM. Measurement of blood flow from firstpass radionuclide angiography: influence of bolus volume [Ｊ]. Eur J Nucl Med, 1991; 18(11)∶885.
  9. 9. Klotz E, Konig M. Perfusion measurements of the brain: using dynamic CT for the quantitative assessment of cerebral ischemia in acute stroke [Ｊ]. Eur J Radiol, 1999; 30(3)∶170.
  10. 10. Koenig M, Klotz E, Luka B, et al. Perfusion CT of the brain: diagnostic approach for early detection of ischemic stroke [Ｊ] Radiology, 1998; 209(1)∶85.
  11. 11. Miles KA. Tumour angiogenesis and its relation to contrast enhancement on computed tomography: a review [Ｊ]. Eur J Radiol, 1999; 30(3)∶198.
  12. 12. Dugdale PE, Miles KA, Bunce I, et al. CT measurement of perfusion and permeability within lymphoma masses and its ability to assess grade, activity, and chemotherapeutic response [Ｊ]. J Comput Assist Tomogr, 1999; 23(4)∶540.
  13. 13. Brix G, Bahner ML, Hoffmann U, et al. Regional blood flow, capillary permeability, and compartmental volumes: measurement with dynamic CTinitial experience [Ｊ]. Radiology, 1999; 210(1)∶269.
  14. 14. Miles KA, Leggett DA, Kelley BB, et al. In vivo assessment of neovascularization of liver metastases using perfusion CT [Ｊ]. Br J Radiol, 1998; 71(843)∶276.
  15. 15. Bader TR, Herneth AM, Blaicher W, et al. Hepatic perfusion after liver transplantation: noninvasive measurement with dynamic singlesection CT [Ｊ]. Radiology, 1998; 209(1)∶129.
  16. 16. Leggett DA, Kelley BB, Bunce IH, et al. Colorectal cancer: diagnostic potential of CT measurements of hepatic perfusion and implications for contrast enhancement protocols [Ｊ]. Radiology, 1997; 205(3)∶716.